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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | Secure Spread Spectrum Watermarking for Multimedia显示文摘 | Cox I J Kilian J Leighton F T | | 0，，： | 3 |
| 4 | 用可调式涡轮增压技术降低排放并改善扭矩特性显示文摘目前,欧洲80%的轿车柴油机已采用涡轮增压。随着排放标准的日益严格,在不久的将来,涡轮增压机型有望接近100%。目前的一个主要热点是在高速柴油机上采用可调式涡轮增压技术(VGT)。在一台1.8L直喷式柴油机上做了大量的稳态试验研究,旨在对可调式涡轮增压发动机与配置带放气阀增压器的基准发动机进行比较,以观其潜在的益处。在欧洲试验循环中对排放产物十分重视的部分负荷工况下,分别控制可调增压器的叶片位置和废气再循环(EGR)阀的位置,以优化排放指标。在不牺牲固定式增压发动机的燃油耗、烟度的前提下,在一些间断工况点测得的NO_X减少到45%。在满足最高爆发压力、烟度和涡轮前温度限制条件下,可调增压发动机与装有固定增压基准发动机相比最大扭矩提高了10%。 | Hawley J G Wallace F J Cox A 栾敏 董复兴 | 2000 | 国外内燃机2000，，3： | 3 |
| 5 | Fulid infiltration and volume changes during mid-crustal mylonite of Proterozz granite, King Island, Tasmamia 显示文摘 | Streit J E Cox S F | 1998 | Journal of Metamorphic Geology1998，16，： | 2 |
| 6 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 7 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 8 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 9 | Secure spread spectrum watermarking for multimedia 显示文摘 | Cox I J Killian J Leighton F T | 1997 | IEEE Trans Image Processing1997，6，12： | 1 |
| 10 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 11 | Impaet of molecular structure on the performance of methyl ester ethoxylates 显示文摘 | Cox M F Weerasooriya U | 1998 | J Surf Deterg1998，1，1： | 1 |
| 12 | Secure spread spectrumwater marking for multimedia显示文摘 | Cox I J Killian J Leighton F T | 1997 | IEEE Trans Image Processing1997，6，： | 1 |
| 13 | Soil test phosphorus and clay content effects on runoff water quality显示文摘 | Cox F A Hendricks S E | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 14 | Valuing corporate securities: some effects of bond indenture provision显示文摘 | Black F Cox J C | 1976 | Journal of Finance1976，，： | 1 |
| 15 | C shaped canal configurations in mandibular molar显示文摘 | Cook H G 3rd Cox F L | 1979 | J Am Dent Assoc1979，99，5： | 1 |
| 16 | Impact of molecular structure on the performance of methyl ester ethoxylates显示文摘 | Michael F Cox Upali Weerasooriya | 1998 | Journal of the American Oil Chemists'' Society1998，，1： | 1 |
| 17 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 18 | Factors influencing quality of life in patients with active tuberculosis显示文摘 | Marra CA Marra F Cox VC | | 0，，： | 1 |
| 19 | Valuaing corporate securities:some effects of bond indenture provisions显示文摘 | BLACK F COX J C | 1976 | Journal of Finance1976，31，： | 1 |
| 20 | Valuing corporate securities:Some effects of bond indenture provisions显示文摘 | Black F Cox C | 1976 | Journal of Finance1976，31，2： | 1 |
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