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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Pyrosequencing of Mytilus galloprovincialis cDNAs= tissue-specific ex pression patterns显示文摘 | Craft J A Gilbert J A Temperton B | 2010 | PLoS ONE2010，5，1： | 1 |
| 3 | Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and repro ductive success in the sand goby显示文摘 | CRAIG D R BROWN E CRAFT J A | 2003 | Aquatic Toxicology2003，，62： | 1 |
| 4 | Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort显示文摘 | Beckmann KR Buckingham J Craft P | 2011 | Breast2011，20，2： | 1 |
| 5 | Determination of the principal directions of azimuthal anisotropy from P-wave seismic data 显示文摘 | Mallick S Craft K L Meister L J | 1998 | Geophysics1998，63，2： | 1 |
| 6 | Active vibration control using optimized modified acceleration feedback with Adaptive Line Enhancer for frequency tracking显示文摘 | Mahmoodi N Craft S Southward M J | | 0，，： | 1 |
| 7 | Will GnRH antagonists provide new hope for patients considered‘difficult responders′to GnRH agonist protocols?显示文摘 | Craft I Gorgy A Hill J | 1999 | Hum Reprod1999，14，： | 1 |
| 8 | From T to B and back again:positive feedback in systemic autoimmune dis- ease 显示文摘 | Shlomchik M J Craft JE Mamula MJ | 2001 | Nat Rev Immunol2001，1，2： | 1 |
| 9 | Processing symbolic information from a visual display: interference from an irrelevant directional cue显示文摘 | Craft J L Simon J R | 1970 | Journal of Experimental Psychology1970，83，3： | 1 |
| 10 | From T to B and back again:positive feedback in systemic autoimmune disease显示文摘 | shlomchik M J craft J E Malnula M J | 2001 | Nat Rev Immunol2001，1，2： | 1 |
| 11 | Inhibition of photosynthesis by heat stress: the activation state of rubisco as a limiting faetor in photosynthesis 显示文摘 | Salvucci E Crafts J | 2004 | Physiologia Plantarum2004，120，2： | 1 |
| 12 | KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin ac- tivities 显示文摘 | Jasinski S Piazza P Craft J | 2005 | Current Biology2005，15，17： | 1 |
| 13 | The roLe of high-LET ratiotherapy compared to conformal photon radiothe Therapy in adenoid cysitc carcinoma Stra Nentehet显示文摘 | DEbus J Engenhart-Cabillic craft G | | Onkol0，，： | 1 |
| 14 | Development and application of a cubic eddy-viscosity model of turbulence显示文摘 | Craft T J Launder B E Suga K | 1996 | International Journal of Heat and Fluid Flow1996，17，2： | 1 |
| 15 | Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and reproductive success in the sand goby (pomatoschistus minutus, pallas) 显示文摘 | Robinson C D Brown E Craft J A Davies I M Moffat C F Pirie D Robertson F Stagg R M Struthers S | 2003 | Aquatic Toxicology2003，62，2： | 1 |
| 16 | Impinging jet studies for turbulence model assessment Part Ⅱ:an examination of the performance of four turbulence models显示文摘 | CRAFT T J GRAHAM L J W LAUNDER B E | | 0，，： | 1 |
| 17 | Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice显示文摘 | OKADA M CRAFT J | 2002 | Cell Immunol2002，217，12： | 1 |
| 18 | Determination of the principal directions of azimuthal anisotropy from P-wave seismicdata显示文摘 | Mallick S Craft K L Meister L J | 1998 | Geophysics1998，63，2： | 1 |
| 19 | Recent and long-term organic soil accrretion and nutrient accumulation in the everglades显示文摘 | CRAFT C B RICHARDSON C J | | 0，，03： | 1 |
| 20 | Effect of local,long-term delivery of platelet-derived growth factor (PDGF) on injected fat graft survival in severe combined immunodeficient (SCID) mice显示文摘 | Craft RO Rophael J Morrison WA | 2009 | J Plast Reconstr Aesthet Surg2009，62，2： | 1 |
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