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| 1 | Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr‐holes:A report of three cases显示文摘Objectives: In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr‐hole plug for the reconstruction of craniotomy burr‐holes. Methods: Mineralized collagen burr‐hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr‐hole plugs were implanted into three patients, and clinical outcomes were evaluated at one‐year follow‐ups. Results: All bone defects healed very well using the mineralized collagen burr‐hole plugs, and there were no adverse reactions at the surgical sites. Conclusions: The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr‐holes in the skull after craniotomy. | Zhiye Qiu Yuqi Zhang Ziqiang Zhang Tianxi Song Fuzhai Cui | 2015 | Translational Neuroscience and Clinics2015，1，1： | 13 |
| 2 | A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep显示文摘Large-sized cranial bone defect repair presents a great challenge in the clinic.The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support,excellent biocompatibility,good osseointegration and biodegradability as well.In this study,a high-strength mineralized collagen(MC)bone scaffold was developed with biomimetic composition,microstructure and mechanical properties for the repair of sheep largesized cranial bone defects in comparison with two traditional cranioplasty materials,polymethyl methacrylate and titanium mesh.The compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical properties.The strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact bone.In vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells(hBMSC)had good viability,attachment and proliferation on the compact MC scaffold indicating its excellent biocompatibility.An adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone defects.The results were investigated by gross observation,computed tomography scanning as well as histological assessments.The in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone regeneration.Our results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair. | Shuo Wang Zhijun Zhao Yongdong Yang Antonios G.Mikos Zhiye Qiu Tianxi Song Fuzhai Cui XiumeiWang Chunyang Zhang | 2018 | Regenerative Biomaterials2018，5，5： | 9 |
| 3 | Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats显示文摘Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion area.As a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain repair.In the present study,HA-KLT hydrogel was developed via modifying HA with a VEGF mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and interaction.Compared with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in vitro.Furthermore,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat brain.Our results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after implantation.Moreover,they could efficiently inhibit the formation of glial scars at the injured sites.The HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in vivo.Collectively,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue. | Jiaju Lu Fengyi Guan Fuzhai Cui Xiaodan Sun Lingyun Zhao Ying Wang Xiumei Wang | 2019 | Regenerative Biomaterials2019，6，6： | 5 |
| 4 | Skull repair materials applied in cranioplasty: History and progress显示文摘The skull provides protection and mechanical support, and acts as a container for the brain and its accessory organs. Some defects in the skull can fatally threaten human life.Many efforts have been taken to repair defects in the skull, among which cranioplasty is the most prominent technique. To repair the injury, numerous natural and artificial materials have been adopted by neurosurgeons. Many cranioprostheses have been tried in the past decades, from autoplast to bioceramics. Neurosurgeons have been evaluating their advantages and shortages through clinical practice. Among those prostheses, surgeons gradually prefer bionic ones due to their marvelous osteoconductivity,osteoinductivity, biocompatibility, and biodegradability. Autogeneic bone has been widely recognized as the 'gold standard' for renovating large-sized bone defects. However, the access to this technique is restricted by limited availability and complications associated with its use. Many metal and polymeric materials with mechanical characteristics analogous to natural bones were consequently applied to cranioplasty. But most of them were unsatisfactory concerning osteoconductiion and biodegradability owe to their intrinsic properties. With the microstructures almost identical to natural bones, mineralized collagen has biological performance nearly identical to autogeneic bone, such as osteoconduction. Implants made of mineralized collagen can integrate themselves into the newly formed bones through a process called 'creeping substitution'. In this review, the authors retrospect the evolution of skull repair material applied in cranioplasty. The ultimate skull repair material should have microstructure and bioactive qualities that enable osteogenesis induction and intramembranous ossification. | Qingsheng Yu Lin Chen Zhiye Qiu Yuqi Zhang Tianxi Song Fuzhai Cui | 2017 | Translational Neuroscience and Clinics2017，3，1： | 4 |
| 5 | Study on vertical mandibular distraction osteogenesis using magnesium alloy on canine显示文摘The bone formation feasibility by a novel magnesium alloy device was evaluated using a canine vertical mandibular distraction osteogenesis(DO) model. Osteotomies were performed in the area where last 3 star's teeth of left mandibular were pulled out before 3 months. Both AZ31 magnesium alloy(n ? 6) and 316 L stainless steel(n ? 6) distraction devices were implanted. The distraction osteogenesis was carried out with a latency of 5 days after mandibular osteotomy. Distraction proceeded at a rate of 0.3 mm/8 h for 7 days and followed by 4 weeks of consolidations. The evaluations were conducted by scanning electron microscopy(SEM) and histological examinations. There were osteoblasts and trabecular bones formations manifestly in both groups. There was no significant difference in the bone mineral density between the two groups. The surface of the magnesium alloy was much more cracked and uneven, resulting from the surface pitting corrosion. The crew nails were closely combined with the surrounding bone tissue. AZ31 magnesium alloy exhibited a certain degradation rate in mandibular and did not post a negative effect on the kidney and liver. The observations in magnesium alloys group is consistent with the stainless steel group. | Chengyue Wang Shufeng Wang Yusheng Yao Fuzhai Cui | 2014 | Progress in Natural Science:Materials International2014，24，5： | 4 |
| 6 | Gene expression profiling and mechanism study of neural stem cells response to surface chemistry显示文摘To declare the mechanisms of neural stem cells(NSCs)in response to material surface chemistry,NSCs were exposed to the self-assemble monolayers of alkanethiolates on gold surfaces terminated with amine(NH2),hydroxyl(OH)and methyl(CH3)for analysis.The morphological responses of NSCs were recorded;the gene expression profilings were detected by genechips;the gene expressions data of NSCs responded to different chemical groups were declared through the gene ontology term and pathway analyses.It showed that cells behaved dissimilar on the three chemical groups,the adhesion,proliferation and migration were easier on the NH2 and OH groups;the gene expressions of NSCs were induced differently,either,involved in several functional processes and signaling pathways.CH3 group induced genes enriched much in chemistry reactions and death processes,whereas many genes of cellular nucleotide metabolism were down-regulated.NH2 group induced NSCs to express many genes of receptors on membrane,and participated in cellular signal transduction of cell adhesion and interactions,or associated with axon growth.OH group was similar to NH2 group to induce the membrane response,but it also down regulated metabolism of cells.Therefore,it declared the chemical groups affected NSCs through inner way and the NH2,OH and CH3 groups triggered the cellular gene expression in different signaling pathways. | Ying Wang Shenglian Yao Qingyuan Meng Xiaolong Yu Xiumei Wang Fuzhai Cui | 2014 | Regenerative Biomaterials2014，1，1： | 4 |
| 7 | Two competitive nucleation mechanisms of calcium carbonate biomineralization in response to surface functionality in low calcium ion concentration solution显示文摘Four self-assembled monolayer surfaces terminated with–COOH,–OH,–NH_(2)and–CH_(3)functional groups are used to direct the biomineralization processes of calcium carbonate(CaCO_(3))in low Ca^(2+)concentration,and the mechanism of nucleation and initial crystallization within 12 h was further explored.On-COOH surface,nucleation occurs mainly via ion aggregation mechanism while prenucleation ions clusters may be also involved.On-OH and-NH_(2)surfaces,however,nucleation forms via calcium carbonate clusters,which aggregate in solution and then are adsorbed onto surfaces following with nucleation of amorphous calcium carbonate(ACC).Furthermore,strongly negative-charged-COOH surface facilitates the direct formation of calcites,and the-OH and-NH_(2)surfaces determine the formation of vaterites with preferred crystalline orientations.Neither ACC nor crystalline CaCO_(3)is observed on-CH_(3)surface.Our findings present a valuable model to understand the CaCO_(3)biomineralization pathway in natural system where functional groups composition plays a determining role during calcium carbonate crystallization. | Hua Deng Shuo Wang Xiumei Wang Chang Du Xingcan Shen Yingjun Wang Fuzhai Cui | 2015 | Regenerative Biomaterials2015，2，3： | 3 |
| 8 | SEGREGATION EFFECT ON SURFACE COMPOSITION IN ALLOY SPUTTERING显示文摘The modified dynamic TCIS(Transport and atomic Collision cascade of energetic Ions an Solids)Monte Carlo program including the radiation-enhanced Gibbsian segregation(REGS)is employed to estimate the compositional distributions at surface of the Au_(0.56)Cu_(0.44) alloy under 2keV Ar^(+) ion bombardment at high dose.The calculation results exhibit that the Au composition enriches in the first layer(74 at.%),depletes in the second layer(37 at.%)and gradually rises with depth to the bulk composition.The effect of the relation between sputter depth and segregation layer on the surface concentration of Au_(0.56)Cu_(0.44) is also discussed. | ZHENG Liping LI Risheng LI Mingyao CUI Fuzhai | 1990 | Chinese Physics Letters1990，7，3： | 2 |
| 9 | Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly(lactic acid) bone substitute显示文摘Infected bone defects are normally regarded as contraindications for bone grafting.In the present study,an antibacterial bone graft substitute was synthesized by loading vancomycin(VCM) in our previously developed mineralized collagen based composite,nano-hydroxyapatite/collagen/poly(lactic acid)(nHAC/PLA),aiming to repair large size bone defects and inhibit related infections simultaneously.The VCM/nHAC/PLA showed typical porous structure with a porosity of(80.7± 6.7)%and compressive strength of 1.52 MPa.The delivery of VCM from VCM/nHAC/PLA was detected in vitro for up to 4weeks.And their antibacterial properties were determined using inhibition ratio assay and inhibition zone assay.Pretty high level of inhibition ratio(more than 99%) was obtained in VCM/nHAC/PLA group.Additionally,a distinct inhibition zone was clearly formed in Staphylococcus aureus bacterium incubation dish with VCM/nHAC/PLA disc for up to 18 days of incubation.Moreover,both of the nHAC/PLA composites with or without VCM exhibited favorable in vitro and in vivo biocompatibilities for rabbit marrow stromal cells(MSCs) adhesion,spreading,proliferation,and triggering no obvious inflammation responses in subcutaneous implantation.Our results suggested that the VCM/nHAC/PLA performed ideal antibacterial property and biocompatibility and has great promise for the treatment of bone defect-related infections in orthopedic surgeries. | Xiaojie Lian Huanye Liu Xiumei Wang Suju Xu Fuzhai Cui Xizhuang Bai | 2013 | Progress in Natural Science:Materials International2013，23，6： | 2 |
| 10 | Histopathological and imageological studies on clinical outcomes of mineralized collagen reconstruction rod for femoral head necrosis with one case report显示文摘In this article,the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods.Computed radiography(CR)computerized tomography(CT),common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head,interface between the host bone and implant and the bone reconstruction process.The results showed that the density of rods increased closed to that of host bones after 1 year implanting,and the interface between them turns to blurring.Hard tissue grinding sections analysis showed osteocytes appearing in sparse bone trabecular and bone pit region,as well as a few vessels in the degraded dye powder matrix were noticed,indicating the new bone forming between the implants and host bones.Regular decalcified sections analysis showed scattered osteoclasts,multinucleated giant cells and fibrosis components existing in the degraded rod and the host bone trabecular.Degraded debris was endocytosed by giant cells,and vascular network formed around the boundaries of the implanted rod.The good osteointegration has been expressed by the interface between the implanted rod and the host bone becoming blurred.Histological results indicated that the implanted rod degradation process and new bones regeneration simultaneously occurred around the boundaries of embedding rod.New bone and host bone were hinged and co-existed. | Baogang Xie Hao Wang Jianhua Hao Ping Wang Na Zhang Jingjing Wu Zhiye Qiu Fuzhai Cui | 2017 | Regenerative Biomaterials2017，4，4： | 2 |
| 11 | Effect of bombarding energy on ion beam assisted deposited DLC film on UHMWPE显示文摘Diamond-like carbon (DLC) films on ultra-high molecular weight polyethylene substrates were prepared at CHn+ ion bombarding energies of 200-1000eV at room temperature using ion beam assisted deposition technique. The wear tests exhibited a high wear resistance for all DLC films. X-ray photoelectron spectfoscopy and Raman spectroscopy analysis indicated that DLC film was amorphous with a characteristic high fracdion of sp3 bonds in the structure of mixed sp:2+ sp3 bonding at an optimal bombardingenergy of 600eV. | Dejun LI Hanqing GU and Fuzhai CUI(1. Department of physics, Tianjin Normal University, Tianjin 300074, P.R.China2. Institute of Urology Surgery, Tianjin 300211, P.R.China3. Department of Materials Science and Engineering, Tsinghua University, Beijing | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，4： | 2 |
| 12 | Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases显示文摘Objective:To evaluate the clinical results of repairing skull defects with biomimetic bone(nano-hap/collagen composites,NHACs)in children.Methods:Thirteen children with skull defects were treated with NHACs in our hospital.The NHACs molded with the help of a 3D printer were used in the operations.Results:All 13 operations were successful,and patients recovered without infection.Only one patient suffered from subcutaneous hydrops post-operation.The implanted NHACs remained fixed well after 1 year,and their CT HU values raised gradually.Skull shapes of children developed normally.Recovery of neurological and cognitive function was significant.Conclusions:NHAC,chosen to repair skull defects in children,can coexist with normal skull and reduce the negative effects on growth and development.NHAC could be a good choice for children with skull defects. | Tuoyu Chen Yuqi Zhang Huancong Zuo Yapeng Zhao Chaoqiang Xue Bin Luo Qinglin Zhang Jin Zhu Xiumei Wang Fuzhai Cui | 2016 | Translational Neuroscience and Clinics2016，2，1： | 2 |
| 13 | Surface Modifications of Magnesium Alloys for Biomedical Applications显示文摘 | Jingxin Yang Fuzhai Cui | 2011 | Annals of Biomedical En- gineering2011，39，7： | 1 |
| 14 | Property variations in the prism and the organic sheath within enamel by nanoindentation显示文摘 | Ge Jun Cui Fuzhai Wang Xiumei | 2005 | Biomaterials2005，26，16： | 1 |
| 15 | 显示文摘 | Huang Zhaolong Zhang Wei Cui Fuzhai | 2004 | Spectroscopy and Spectral Analysis2004，24，5： | 1 |
| 16 | 显示文摘 | Mao Chuanbin Li Hengde Cui Fuzhai | 1999 | Journal of Crystal Growth1999，206，： | 1 |
| 17 | Calcium phosphate coating on magnesium alloy for modification of degradation behavior显示文摘 | Cui Fuzhai Yang Jingxin Jiao Yanpeng | 2008 | Frontiers of Materials Science in China2008，2，2： | 1 |
| 18 | Ion-beam assisted deposited C-N coating on magnesium alloys显示文摘 | Yang Jingxin Cui Fuzhai Lee IS | 2008 | Surface and Coatings Technology2008，202，2223： | 1 |
| 19 | Modification of degradation behavior of magnesium alloy by IBAD coating of calcium phosphate显示文摘 | Yang Jingxin Jiao Yanpeng Cui Fuzhai | 2008 | Surface and Coatings Technology2008，202，2223： | 1 |
| 20 | The Functionalization of Titanium With EDTA to Induce Biomimetic Mineralization of Hydroxyapatite显示文摘 | Mao Chuanbin Li Hengde Cui Fuzhai | 1999 | J Mater Chem1999，，9： | 1 |
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