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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Crustal P-wave velocity structure of the Longmenshan region and its tectonic implications for the 2008 Wenchuan earthquake显示文摘The P-wave velocity structure of the crust in the Longmenshan region has been imaged by seismic travel time tomography us ing local and regional first P-wave arrivals recorded from 2000 to 2008. The tomographic model provides a way to analyze the deep tectonics of the Longmenshan fault belt and the tectonic implications for the 2008 Ms8.0 Wenchuan earthquake. The P-wave velocity images indicate that the initial rupture site and focal depth of the Wenchuan earthquake, together with the di rection of rupture propagation, closely relate to the crustal structure of the Longmenshan region. The Pengguan massif to the west of the Longmenshan fault belt is characterized by high velocity anomalies, suggesting that the crust has a strong strain strength that can accumulate large stresses over a long period. The Ms8.0 Wenchuan earthquake is located at the southwestern end of the Pengguan massif and the western edge of the Sichuan Basin. The collision between the Pengguan massif and the Sichuan Basin becomes the primary reason for the occurrence of the Ms8.0 Wenchuan earthquake. To the north of Wenchuan, the occurrence and propagation of rupture benefit from low velocity anomalies along the Longmenshan fault belt; whereas to the south of Wenchuan, the brittle rupture can occur with more difficulty in relatively weak crust with low velocities. This may be one of the reasons for the absence of aftershocks to the south of Wenchuan, and the rupture induced by the Ms8.0 Wenchuan earthquake propagating from the north to the south along the Longmenshan fault belt. The deep geodynamics of the Ms8.0 Wenchuan earthquake may occur due to the discrepancy of crustal structures on the two sides of the Longmenshan fault belt. Ductile deformation and crustal flow can easily occur in the weak middle-lower crust beneath the Songpan-Garze orogenic belt. The eastward movement of the Tibetan Plateau is obstructed by the rigid lithosphere of the Sichuan Basin, and then the thick ening of the middle-lower crust and vertical deformation occur in the crust of the Longmenshan fault belt. In addition, the down-warping of the Moho and the basement thrusting onto the range front induced crustal deformation and strain accumula tion, which provided the potential energy to trigger the occurrence of the Ms8.0 Wenchuan earthquake. | LI ZhaWei XU Yi HUANG RunQiu HAO TianYao XU Ya LIU JingSong LIU JianHua | 2011 | Science China Earth Sciences2011，54，9： | 23 |
| 3 | Crust and upper mantle structure of the Ailao Shan-Red River fault zone and adjacent regions显示文摘Using arrival data of the body waves recorded by seismic stations, we reconstructed the velocity structure of the crust and upper mantle beneath the southeastern edge of the Tibetan Plateau and the northwestern continental margin of the South China Sea through a travel time tomography technique. The result revealed the apparent tectonic variation along the Ailao Shan-Red River fault zone and its adjacent regions. High velocities are observed in the upper and middle crust beneath the Ailao Shan-Red River fault zone and they reflect the character of the fast uplifting and cooling of the metamorphic belt after the ductile shearing of the fault zone, while low velocities in the lower crust and near the Moho imply a relatively active crust-mantle boundary beneath the fault zone. On the west of the fault zone, the large-scale low velocities in the uppermost mantle beneath western Yunnan prove the influence of the mantle heat flow on volcano, hot spring and magma activities, however, the upper mantle on the east of the fault zone shows a relatively stable structure similar to the Yangtze block. The low velocities of the deep mantle beneath the southeastern extending segment of the fault zone are probably related to the mantle convection produced by the pull-apart of the South China Sea. | XU Yi LIU Jianhua LIU Futian SONG Haibin HAO Tianyao JIANG Weiwei | 2005 | Science China Earth Sciences2005，48，2： | 18 |
| 4 | Effect of Magnetic Field on Tribological Properties of Lubricating Oils with and without Tricresyl Phosphate显示文摘Tribological properties of neat 150 SN mineral base oil and the oils doped with different contents of tricresyl phosphate(TCP) under magnetic field or non-magnetic field were evaluated on a four-ball tribotester, on which an external magnetic field was applied. Furthermore, the morphology and the tribochemical characteristics of the worn surfaces were examined with a scanning electron microscope(SEM) and an X-ray photoelectron spectrograph(XPS). The tribological test results showed that the magnetic field improved anti-wear properties but impaired the friction-reducing properties of neat base oil and the TCP-doped oils. The worn surfaces tested in magnetic field were characterized by a slighter wear than those tested in normal condition, especially for the surfaces lubricated with the TCP-doped oils. Furthermore, the results of XPS analysis indicated that tribochemical films on the surfaces tested with TCP-doped oils were mainly composed of ferriccontaining compounds such as Fe_2O_3, Fe_3O_4 and FePO_4. Under the influence of a magnetic field, the atomic concentrations of oxygen and phosphorous in the frictional sub-surfaces were higher than those without magnetic impact. Thus it can be inferred that the improved anti-wear properties and impaired friction-reducing capabilities of lubricating oils with TCP under a magnetic field were related to the diffusion of phosphorus and oxygen into the substrate induced by magnetism. | Jiang Zeqi Fang Jianhua Chen Boshui Zheng Zhe Li Hao Xu Lai | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，3： | 12 |
| 5 | Centimeter-scale growth of two-dimensional layered high-mobility bismuth films by pulsed laser deposition显示文摘Ever since discovery of graphene,two-dimensional(2D)materials become a new tool box for information technology.Among the 2D family,ultrathin bismuth(Bi)has attracted a great deal of attention in recent years due to its unique topological insulating properties and large magnetoresistance.However,the scalable synthesis of layered Bi ultrathin films is rarely been reported,which would greatly restrict further fundamental investigation and practical device development.Here,we demonstrate the direct growth of homogeneous and centimeter-scale layered Bi films by pulsed laser deposition(PLD)technique.The as-grown Bi film exhibits high-purity phase and good crystallinity.In addition,both(111)and(110)-oriented Bi films can be synthesized by precisely controlling the processing temperature.The characterization of optical properties shows a thickness dependent band gaps(0.075-0.2 eV).Moreover,Bi thin-film-based field-effect transistors have been demonstrated,exhibiting a large carrier mobility of 220 cm2 V−1 s−1.Our work suggests that the PLD-grown Bi films would hold the potential to develop spintronic applications,electronic and optoelectronic devices used for information science and technology. | Zhibin Yang Zehan Wu Yongxin Lyu Jianhua Hao | 2019 | InfoMat2019，1，1： | 11 |
| 6 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 7 | Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model显示文摘Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy. | Hao Fan YuGuo Xiaoyan Liang Yibiao Yuan Xiaohong Qi Min Wang Jianhua Ma Hong Zhou | 2013 | The Journal of Biomedical Research2013，27，4： | 10 |
| 8 | Brassinosteroids function in spikelet differentiation and degeneration in rice显示文摘Brassinosteroids(BRs) play crucial roles in many aspects of plant development. However, their function in spikelet differentiation and degeneration in rice(Oryza sativa L.) remains unclear. Here, we investigated the roles of these phytohormones in spikelet development in fieldgrown rice subjected to five different nitrogen(N)fertilization treatments during panicle differentiation. BR levels and expression of genes involved in BR biosynthesis and signal transduction were measured in spikelets. Pollen fertility and the number of differentiated spikelets were closely associated with 24-epicastasterone(24-epiCS) and 28-homobrassinolide(28-homoBL) levels in spikelets.Enhanced BR biosynthesis and signal transduction, in response to N treatment, enhanced spikelet differentiation, reduced spikelet degeneration, and increased grain yield. Increases in proton-pumping ATPase activity, ATPconcentration, energy charge, and antioxidant system(AOS) levels were consistent with 24-epiCS and28-homoBL concentrations. Exogenous application of 24-epiCS or 28-homoBL on young panicles induced a marked increase in endogenous 24-epiCS or 28-homoBL levels, energy charge, AOS levels, spikelet differentiation, and panicle weight. The opposite effects were observed following treatment with a BR biosynthesis inhibitor. Our findings indicate that, in rice, BRs mediate the effects of N fertilization on spikelet development and play a role in promoting spikelet development through increasing AOS levels and energy charge during panicle development. | Weiyang Zhang Kuanyu Zhu Zhiqin Wang Hao Zhang Junfei Gu Lijun Liu Jianchang Yang Jianhua Zhang | 2019 | Journal of Integrative Plant Biology2019，61，8： | 10 |
| 9 | Theory of annual runoff evolution under natural-artificial dual mode and case study of Wuding River basin on the middle Yellow River显示文摘Water cycling process in a river basin becomes more complicated because of the intensified impact by human activities. Study of the law of annual runoff evolution in a river basin is of great significance to quantitative analysis of the water resources condition in varied environment and prediction of the law of the water resources evolution in the future because year-based time span may best reflect the law of the water resources evolution driven by the nature and human activities in the river basin. This paper advances the theory of annual runoff evolution under natural-artificial dual mode based on the dual mode of the water resources evolution, and the theory is applied for the Wuding River Basin on the middle Yellow River as a case study. A thorough analysis of the precipitation-runoff relationship is made in the case of dynamic variation of ground surface conditions of the Wuding River basin, and the concept of water-soil conservation index area that indicates adoption of various measures for water and soil conservation to reflect ground surface conditions. Furthermore, precipitation-runoff empirical model is developed to reflect dynamic variation of the ground surface conditions of the river basin. The study may lay a solid foundation for the integrated theoretical platform of the law of the water resources evolution in the Yellow River basin and the dual model of the evolution. | WANG Hao WANG Chengming WANG Jianhua ZHOU Zuhao CHEN Yiming | 2004 | Science China(Technological Sciences)2004，47，z1： | 8 |
| 10 | Seismic tomography of the crust and upper mantle in the Bohai Bay Basin and its adjacent regions显示文摘In the Bohai Bay Basin and its adjacent regions(112°―124°E,34°―42°N),there exists abundant gas-petroleum while modern inter-plate seismic activity is robust.Although the tectonic structure of this region is very complicated,plenty of geological,geophysical and geochemical data and results are obtained through previous researches.On the basis of absorbing previous results,especially various kinds of geological and geophysical results,we collect and process the arrival time of P-wave phases of local events and tele-seismic events recorded by the station within this region from 1978 to 2004,build the responding initial model,and image the velocity structure of the crust and upper mantle of this region via tomography.The perturbation images of various depths and velocity profiles imply that the velocity structure of the crust and upper mantle in the Bohai Bay Basin and its adjacent regions is mainly influenced by the surface tectonic units,and is characterized by 'Stripped along east-west,and zoned along south-north';some large-scaled faults penetrate Moho and lithosphere,and provide the channels for the basic lava or hot mass upwelling from the mantle. | ZHANG Ling LIU JinSong HAO TianYao LIU JianHua XU Yi | 2007 | Science China Earth Sciences2007，50，12： | 8 |
| 11 | The investigation on particulate organic carbon fluxes with disequilibria between thorium-234 and uranium-238 in the Prydz Bay,the Southern Ocean显示文摘Dissolved and particulate thorium-234, particulate organic carbon in the upper 150 m of water columns from five stations in the Prydz Bay, the Southern Ocean were determined during the 22nd Chinese National Antarctic Research Expedition (from November 2005 to March 2006). The disequilibria between thorium-234 and its parent uranium-238 in upper layer was used to derive the averaged residence time of thorium-234, which decreased along with the latitude to the south and a minimum value, 1~8 d for particulate thorium-234 and 29~48 d for dissolved thorium-234, appeared at the medium latitude station, and the export fluxes of thorium-234 were calculated too and a maximum value, 0.35~0.63 Bq/(m3·d) for the particulate thorium-234 and 0.44~0.65 Bq/(m3·d) for the dissolved thorium-234, appeared at the same station. The export fluxes of particulate organic carbon at different water columns were derived by two methods with irreversible scavenging model, and the averaged values were 104.7 mmol/ (m2·d) (E method) and 120.6 mmol/(m2·d) (B method), respectively, indicating that a relatively high new production would exist in summer in the Prydz Bay where it will play a potential significant role in sequestering the absorption CO2 to deeper ocean. | HE Jianhua MA Hao CHEN Liqi XIANG Baoqiang ZENG Xianzhang YINMingduan ZENG Wenyi | 2008 | Acta Oceanologica Sinica2008，27，2： | 8 |
| 12 | Bifurcation\instability forms of high speed railway vehicles显示文摘The China high speed railway vehicles of type CRH2 and type CRH3, modeled on Japanese high speed Electric Multiple Units (EMU) E2 series and Euro high speed EMU ICE3 series possess different stability behaviors due to the different matching re-lations between bogie parameters and wheel profiles. It is known from the field tests and roller rig tests that, the former has a higher critical speed while large limit cycle oscillation appears if instability occurs, and the latter has lower critical speed while small limit cycle appears if instability occurs. The dynamic model of the vehicle system including a semi-carbody and a bogie is established in this paper. The bifurcation diagrams of the two types of high speed vehicles are extensively studied. By using the method of normal form of Hopf bifurcation, it is found that the subcritical and supercritical bifurcations exist in the two types of vehicle systems. The influence of parameter variation on the exported function Rec1(0) in Hopf normal form is studied and numerical shooting method is also used for mutual verification. Furthermore, the bifurcation situation, subcritical or supercritical, is also discussed. The study shows that the sign of Re(λ) determinates the stability of linear system, and the sign of Rec1(0) determines the property of Hopf bifurcation with Rec1(0)>0 for supercritical and Rec1(0)<0 for subcritical. | DONG Hao ZENG Jing XIE JianHua JIA Lu | 2013 | Science China(Technological Sciences)2013，56，7： | 7 |
| 13 | Integrated simulation and assessment of water quantity and quality for a river under changing environmental conditions显示文摘The water cycle and water resources within river basins under changing environmental conditions undergo profound changes, which have significant effects on the water environment of the river. Owing to the water resources demanded for economic and social development, water quantity and quality are becoming the core constraints of water resources development and utilization. In this paper, the dual attributes of water resources, progress into research regarding water quantity and quality joint assessment and simulation and the shortcomings associated with these techniques are summarized and described with respect to water quantity and quality. The results indicated that under the current environmental conditions, the method used for traditional water quality assessment of single water bodies cannot meet the requirements for water resources management. Moreover, a coupled hydrodynamic and water quality numerical model for river networks and lakes that applies to the river water environment system was developed for the river network flow and pollutant migration and transformation process and validated. This validation revealed that the error between the simulated values calculated by the model and the monitored values was small, meeting the application requirements and realizing the integrated and dynamic simulation of water quantity and quality of the river water environmental system. On this basis, the integrated simulation model was applied to the Luanhe River Basin. | WANG JianHua XIAO WeiHua WANG Hao CHAI ZengKai NIU CunWen LI Wei | 2013 | Chinese Science Bulletin2013，58，27： | 7 |
| 14 | Necessity and feasibility for an ET-based modern water resources management strategy: A case study of soil water resources in the Yellow River Basin显示文摘The necessity and feasibility of an ET-based modern water resources management was analyzed to improve assessment of critical water resources scarcity in the region/basin. This analysis was based on the whole water cycle process and its analysis object is evapotranspiration (ET), a main consumption component in the water resources dynamic transformation process. A case study was undertaken by selecting soil water resources in the Yellow River Basin and employing the WEP-L distributed hydrological model with physics mechanisms. This paper discusses the amount and consumption efficiency of soil-water resources according to completely simulated results of water cycle elements throughout the basin. Results indicate that it is important for the ET-based modern water resources management strategy to alleviate water resources scarcity because it may not only avoid unused water wasting but also improve water use efficiency. Therefore, an ET-based modern water resources management scheme is a good complement to the traditional water resources demand management system. | WANG Hao YANG GuiYu JIA YangWen QIN DaYong GAN Hong WANG JianHua HAN ChunMiao | 2009 | Science China(Technological Sciences)2009，52，10： | 6 |
| 15 | Strongly secure identity-based authenticated key agreement protocols in the escrow mode显示文摘Escrowable identity-based authenticated key agreement(AKA) protocols are desirable under certain circumstances especially in certain closed groups applications.In this paper,we focus on two-party identitybased AKA schemes in the escrow mode,and present a strongly secure escrowable identity-based AKA protocol which captures all basic desirable security properties including perfect forward secrecy,ephemeral secrets reveal resistance and so on.The protocol is provably secure in the extended Canetti-Krawczyk model,and its security can be reduced to the standard computational bilinear Diffie-Hellman assumption in the random oracle model.Assuming no adversary can obtain the master private key for the escrow mode,our scheme is secure as long as each party has at least one uncompromised secret.Also,we present two strongly secure variants of the protocol,which are computationally more efficient than the original scheme. | NI Liang CHEN GongLiang LI JianHua HAO YanYan | 2013 | Science China(Information Sciences)2013，56，8： | 6 |
| 16 | Effect of irrigation regime on grain yield,water productivity,and methane emissions in dry direct-seeded rice grown in raised beds with wheat straw incorporation显示文摘Dry direct-seeded rice grown in raised beds is becoming an important practice in the wheat–rice rotation system in China.However,little information has been available on the effect of various irrigation regimes on grain yield,water productivity(WP),nitrogen use efficiency(NUE),and greenhouse gas emission in this practice.This study investigated the question using two rice cultivars in 2015 and 2016 grown in soil with wheat straw incorporated into it.Rice seeds were directly seeded into raised beds,which were maintained under aerobic conditions during the early seedling period.Three irrigation regimes:continuous flooding(CF),alternate wetting and drying(AWD),and furrow irrigation(FI),were applied from 4.5-leaf-stage to maturity.Compared with CF,both AWD and FI significantly increased grain yield,WP,and internal NUE,with greater increases under the FI regime.The two cultivars showed the same tendency in both years.Both AWD and FI markedly increased soil redox potential,root and shoot biomass,root oxidation activity,leaf photosynthetic NUE,and harvest index and markedly decreased global warming potential,owing to substantial reduction in seasonalThe results demonstrate that adoption of either AWD or FI could increase grain yield and resource-use efficiency and reduce environmental risks in dry direct-seeded rice grown on raised beds with wheat straw incorporation in the wheat–rice rotation system. | Zhiqin Wang Daojian Gu Sarah S.Beebout Hao Zhang Lijun Liu Jianchang Yang Jianhua Zhang | 2018 | The Crop Journal2018，6，5： | 6 |
| 17 | Effects of titanium on microstructure and mechanical properties of ZnAl4Y alloy显示文摘The effect of Ti on the microstructure and mechanical properties of zinc-aluminum ZnAl4Y alloy has been investigated in this work. Small amount of Ti was added into ZnAl4Y alloy in the form of Al-10wt.%Ti alloy. The results show that Ti addition into ZnAl4Y alloy refines the primary η-Zn phase and increases the amount of η-Zn + α-Al eutectic structure. There exists a ternary T phase in Zn-Al-Ti alloy. Fine TiAl3 particles and Ti-Zn compounds can serve as the nucleation sites of the α-Al and η-Zn phase, respectively, resulting in the refining of the microstructure of ZnAl4Y alloy. Ti addition changes the fracture characteristics of ZnAl4Y alloy. With 0.05wt%Ti, the fracture surface of the alloy shows a lot of dimples and tearing ridges connecting the microscopic dimples, which is mainly ductile fracture morphology. Ti addition into ZnAl4Y alloy also increases the mechanical properties of the alloy. When the content of Ti is 0.05wt.%, the ZnAl4Y alloy possesses the best comprehensive mechanical properties. | Wang Jianhua Wang Xiande Tu Hao Su Xuping | 2011 | China Foundry2011，8，4： | 6 |
| 18 | Theoretical framework of dualistic nature–social water cycle显示文摘The global climate change and intensification of human activities in recent decades have made profound changes in hydrological cycle processes and water resources,and produced serious water problems and water crisis in many areas.The main reason is that the driving force of water cycle,the structure of water cycle,and the parameters of water cycle have dualistically evolved under the influence of human activities,and consequently resulted in reduction of runoff water resources,water pollution,and degradation of natural ecosystems.In order to realize of the safety aim of water supply,water environment,and ecosystem in area which is short of water resources,scientific regulation of water resources must take basin water cycle system as the unified base,and the first scientific basis is the awareness of the internal mechanism and law of water cycle evolution under highly intensive human activities.This article discussed four aspects of dualistic water cycle evolution,including its history in China,its theory,its characteristics in a typical basin,and its description of integral structure,along with the conceptive model system to quantify it.This article can be a reference to the basic cognition of water cycle evolution in a changing environment,and the study of water resources reduction reasons in the contemporary age. | Dayong Qin Chuiyu Lu Jiahong Liu Hao Wang Jianhua Wang Haihong Li Junyin Chu Genfa Chen | 2014 | Chinese Science Bulletin2014，59，8： | 5 |
| 19 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 20 | ^(234)Th/^(238)U disequilibrium and particulate organic carbon export in the northwestern South China Sea显示文摘234 Th was utilized as a tracer of particulate organic carbon (POC) export in the northwestern South China Sea (SCS) on the basis of the data collected at four stations during a spring cruise.Depth profiles of dissolved and particulate 234 Th activities were measured in the upper 60 m,showing a significant deficit relative to 238 U over the investigated stations.A stratified structure of 234 Th-238 U disequilibrium was in general observed in the upper 60 m water column,indicating that the euphotic zone of the northwestern SCS in this reason can be divided into two layers,an upper and lower layer,with different export rates.POC export fluxes were estimated from a one-dimensional steady state model of 234 Th fluxes in combination with the measurement of POC/ 234 Th ratios on suspended particles.The POC export in this region ranged from 8.2 to 20.0 mmol/(m 2 · d),with an average of 16.0 mmol/(m 2 · d),and was slightly higher than those previously reported in the southern SCS. | MA Hao ZENG Zhi YU Wen HE Jianhua CHEN Liqi CHENG Jianping YIN Mingduan ZENG Shi | 2011 | Acta Oceanologica Sinica2011，30，3： | 5 |
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