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| 1 | Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen显示文摘Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is limited.The current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic GBC.Methods:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were retrieved.This retrospective study evaluated the clinical characteristics,survival outcomes and adverse events.Results:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were included.There were no significant differences between groups in baseline characteristics.The median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX group.Conclusions:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies. | Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui Xiang-Song Wu Lu Zou Xiao-Ling Song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang Wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 10 |
| 2 | A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury显示文摘Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of metabolites.In this study,a porous collagen scaffold with axially-aligned luminal conduits was prepared.In vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell differentiation.The collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve regeneration.The collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good biodegradability.Rectal temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory reaction.These findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following injury.This study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019. | Shuo Liu Yuan-Yuan Xie Liu-Di Wang Chen-Xu Tai Dong Chen Dan Mu Yan-Yan Cui Bin Wang | 2021 | Neural Regeneration Research2021，16，11： | 6 |
| 3 | Influence of REV and ALV-J Co-Infection on Immunologic Function of T Lymphocytes and Histopathology in Broiler Chickens显示文摘The aim of present investigation is to study the effect of single- and co-infection with REV and ALV-J on T lymphocytes bioactivities and histopathology in broiler chickens. The bioactivities of blood and spleen T lymphocytes including lymphoproliferation responses, cytotoxicitic responses, and histopathology of spleen were detected in broiler chickens singly- or co-infected with REV and ALV-J at different days post inoculation and the virus expressions in spleen of infected broiler chickens were detected with immunofluorescence assay (IFA). The results indicated that blood and spleen T lymphocytes proliferation responses and cytotoxicity in broilers infected with REV or/and ALV-J were inhibited in the whole observed period compared with controls. In the co-infected chickens they were highly inhibited than in the single-infected. The histopathology of spleen in infected chickens at 17 and 37 d post inoculation (dpi) indicated that cell interium increased, the numbers of lymphocytes decreased, and the regrowth were destroyed or decreased, especially more significantly at 17 than at 37 dpi. The different numbers of virus were detected in spleen lymphocytes in REV- infected and/or ALV-J-infected chickens. In the spleen of co-infected chicken, both REV and ALV-J were detected and the total numbers of viruses were more than in chickens singly-infected with REV or ALV-J. Thus, the co-effect of REV and ALV-J caused more immunosuppression on T lymphocytes bioactivities in broiler chickens than single-effect of ALV-J or REV, which contributed to the sever histopathology and the product of tumor cells. This study will be helpful for understanding the effect of co-infection with many viruses and control them in poultry. | GUO Hui-jun, LI Hong-mei, CHENG Zi-qiang , LIU Jian-zhu and CUI Zhi-zhong Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veternary Medicine, Shandong Agricultural University, Tai’an 271018, P.R.China | 2010 | Agricultural Sciences in China2010，9，11： | 6 |
| 4 | Cloning of the full-length gene of activin receptor-interacting protein2a and characterization of its interaction with ActR Ⅱ A显示文摘为了调查细胞内部的信号 transduction 的机制,由 activin 受体调停了,编码新奇 activin 的全身的基因交往受体的 protein2a (ARIP2a ) 从一个老鼠大脑 cDNA 图书馆被识别。ARIP2a 和 ARIP2 和在导致 activin 的 RAW264 的 ARIP2 的序列。7 房间被比较,并且在 ARIP2a 和 ActRIIA 之间的相互作用被证实。序列分析表明除了 99 th 氨基酸。RT-PCR 试金证明 ARIP2a mRNA 高度在大脑,垂体和睾丸被表示,并且中等在胰和卵巢,但是在另外的纸巾无法发现。而, ARIP2 mRNA 广泛地在我们测试了的所有老鼠纸巾被散布。而且, ARIP2a mRNA 的表示显著地在刺激 activin 的 RAW264 被减少。7 个房间;然而, ARIP2 mRNA 的表示被增加。另外,在 ARIP2a 之间的相互作用和 activin 类型 IIA 受体(ActRIIA ) 被哺乳动物的二混血儿的试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也与 activin 类型 II 受体(ActRIIA ) 交往被哺乳动物的 two-hybird 试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也作为 ARIP 家庭的一篇小说与 activin 类型 II 受体交往。 | CUI Xueling TAI Guixiang ZHANG Hongjun FANG Lin LIU Zhonghui | 2007 | Progress in Natural Science:Materials International2007，17，2： | 5 |
| 5 | Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells显示文摘Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. | Jingyan Ge Yinan Wang Ye Feng Haiyan Liu Xueling Cui Guixiang Tai Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，2： | 4 |
| 6 | Monitoring Value of Multimodal Magnetic Resonance Imaging in Disease Progression of Amyotrophic Lateral Sclerosis: A Prospective Observational Study显示文摘Background: Ongoing efforts have been made to identify new neuroimaging markers to track amyotrophic lateral sclerosis (ALS) progression. This study aimed to explore the monitoring value of multimodal magnetic resonance imaging (MRI) in the disease progression of ALS. Methods: From September 2015 to March 2017, ten patients diagnosed with ALS in Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Multimodal MRI analyses, including gray matter (GM) volume measured by voxel-based morphometry;cerebral blood flow (CBF) evaluated by arterial spin labeling;functional connectivity, including low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), measured by resting-state functional MRI;and integrity of white-matter (WM) fiber tracts evaluated by diffusion tensor imaging, were performed in these patients. Comparisons of imaging metrics were made between baseline and follow-up using paired t-test. Results: In the longitudinal comparisons, the brain structure (GM volume of the right precentral gyri, left postcentral gyri, and right thalami) and perfusion (CBF of the bilateral temporal poles, left precentral gyri, postcentral gyri, and right middle temporal gyri) in both motor and extramotor areas at follow-up were impaired to different extents when compared with those at baseline (all P < 0.05, false discovery rate adjusted). Functional connectivity was increased in the motor areas (fALFF of the right precentral gyri and superior frontal gyri, and ReHo of right precentral gyri) and decreased in the extramotor areas (fALFF of the bilateral middle frontal gyri and ReHo of the right precuneus and cingulate gyri) (all P < 0.001, unadjusted). No significant changes were detected in terms of brain WM measures. Conclusion: Multimodal MRI could be used to monitor short-term brain changes in ALS patients. | Dong-Chao Shen Yin-Yan Xu Bo Hou Hong-Fei Tai Kang Zhang Shuang-Wu Liu Zhi-Li Wang Feng Feng Ming-Sheng Liu Li-Ying Cui | 2018 | Chinese Medical Journal2018，，24： | 4 |
| 7 | Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China显示文摘BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients with T1b GBC.METHODS We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in China.The logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch only.To investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did not.RESULTS Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch only.Seven(9.1%)patients in the Ch+RL group had lymph node metastasis.The 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent Ch.Hep+Ch showed no improvement in prognosis in T1b GBC patients.Although recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC patients.Routine Ch+RL should be advised in T1b GBC. | Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee Lau Ying-Bin Liu | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 8 | A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo显示文摘Activin A,转变生长因素贝它(TGF-) 的一个多功能的因素总科,被 microglia 和巨噬细胞主要生产,并且它的反煽动性并且支持 inflammatory 活动是与巨噬细胞功能有关的两个。然而,在 vivo 的剩余的巨噬细胞上的 activin A 的直接效果仍然保持不清楚。在现在的学习,结果显示出那 activin A 不仅不增加了并且 IL-1 版本,而且在 vitro 并且在 vivo 的鼠标腹巨噬细胞的支持的吞噬细胞的能力,而它没影响 MHC 我和 MHC II 表示。而且,我们显著地发现那 activin A upregulated CD14 和 CD68 的表情,成熟巨噬细胞的标记,在在 vitro 并且在 vivo 的巨噬细胞的表面上。这些数据建议 activin A 能在 vitro 并且在 vivo 导致主要巨噬细胞成熟,但是不能经由调整涉及抗原的表示的 MHC 分子的表示触发获得的有免疫力的反应。 | Yinan Wang Xueling Cui Guixiang Tai Jingyan Ge Nan Li Fangfang Chen Fang Yu Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 9 | Bmi-1 is essential for the tumorigenicity of neuroblastoma cells显示文摘 | bo Hu Tai Li | 2007 | Tumorigenesis and Neoplastic Progression2007，170，4： | 1 |
| 10 | Pivotal role of tyrosine phosphatase SHP- 1 in AT2 receptor- mediated apoptosis in rat fetal vascular smooth muscle cell 显示文摘 | Tai - Xing Cui Hironori Nakagami | 2001 | Cardiovascular Res2001，49，： | 1 |
| 11 | Detection of ECG characteristic points using wavelet transforms显示文摘 | LI Cui Wei ZHENG Chong Xun TAI Chang Feng | 1995 | IEEE Transactions on biomedical engineering1995，，41： | 1 |
| 12 | SecReT4:a web-based bacterial typeⅣ secretion system resource显示文摘 | BI Dexi LIU Linmeng TAI Cui | 2013 | Nucleic Acids Research2013，41，： | 1 |
| 13 | Efficacy and safety of leflunomide' in the treatment of proliferative lupus nephritis : preliminary results from an randomized, Cyclopha- mide-controlled study显示文摘 | Tai Gen Cui Zhao Hui Ni Hang Liu | 2003 | American Society of Nephrology renal week2003，，： | 1 |
| 14 | The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation显示文摘 | Jane Ding Tai Li Xiangwei Wang Erhu Zhao Jeong-Hyeon Choi Liqun Yang Yunhong Zha Zheng Dong Shuang Huang John M. Asara Hongjuan Cui Han-Fei Ding | 2013 | Cell Metabolism2013，，6： | 1 |
| 15 | Comparative efficacy of traditional Chinese herbal injection for chronic renal failure:A systematic review and network meta-analysis of randomized controlled trials显示文摘Objective: To conduct a systematic review and network meta-analysis(NMA) for the comparison of the efficacy and safety of Chinese herbal injection(CHI) combined with Western medicine(WM) and WM monotherapy for chronic renal failure(CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials(RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2(RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection(TQ) + WM was the most effective in reducing serum creatinine(Scr) level. Xingding injection(XD) + WM was the most effective in reducing blood urea nitrogen(BUN) and cystatin C(Cys C) levels. Guhong injection(GH) + WM had the highest endogenous creatinine clearance rate(Ccr). Shuxuetong injection(SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection(DH) + WM resulted in the lowest 24-h urinary protein quantity(24 h-UPQ), while Danshen injection(DS) + WM led to the lowest blood uric acid(UA)level. Shenfu injection(SF) + WM was the most effective in increasing hemoglobin(Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF.Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF. | Dongni Shi Feng Liang Xihong Wang Nana Wang Lin Zhang Wanting Cui Jiashuai Deng Chung Tai Lau Luofan Zhang Xuan Zhang | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 1 |
| 16 | Efficacy and Safety of Leflumide in the treatment of proliferative lupus nephritis:preliminary results from an randomized Cyclophosphamide-comtrolled study显示文摘 | Tai Gen Cui Zhao Hui Ni Hang Liu | 2003 | American Society of Nethrology renal week2003，11，： | 1 |
| 17 | Extraordinary radiation tolerance of a Ni nanocrystal-decorated carbon nanotube network encapsulated in amorphous carbon显示文摘Nanostructured materials with abundant defect sinks show good radiation tolerance due to their efficient absorption of irradiation-induced interstitials and vacancies.However,the poor thermal stability and limited size of such nanomaterials severely limit their practical applications.Herein,we report a novel flexible free-standing network-structured hybrid consisting of amorphous carbon encapsulated nickel nanocrystals anchored on a single-wall carbon nanotube scaffold with excellent radiation tolerance up to 5 dpa at 673 K and exceptional thermal stability up to 1073 K.The nano-scale Ni-SWCNT network with abundant Ni-SWCNT interfaces and grain boundaries provides effective sinks and fast transportation channels for defects,which effectively absorb irradiation-induced defects and improved the irradiation tolerance.Furthermore,the formation of a low-energy Ni-C interface and surface thermal grooves significantly reduces the system free energy and increased thermal stability.The amorphous carbon layer produces an external compressive radial stress that inhibits Ni grain boundaries from migrating,which greatly improves the thermal stability of the hybrid by pinning GBs at grooves between grains and facilitates the annihilation of irradiation-induced defects at the sinks.This work provides a new strategy to improve the thermal stability and radiation tolerance of nano-materials used in an irradiation environment. | Kan Cui Yang Zhao Zhi Yu Miaosen Yu Xiaoqi Li Xingwei Huang Jianhang Qiu Liangting Sun Hongwei Zhao Ning Gao Kaiping Tai Chang Liu | 2023 | Journal of Materials Science & Technology2023，，24： | 0 |
| 18 | STUDY OF STRUCTURE,MAGNETIC PROPERTIES AND PREPARATION OF Sm_2Fe_(17)N_x POWDER WITH HIGH ENERGY PRODUCTS显示文摘The effects of hydrogenation before nitrogenization of Sm2Fe17 alloy on structure andmagnetic properties of Sm2Fe17Nx powder are studied in this paper.The unit cell volume ofSm2Fe17increases by about 3.6% and many cracks occur in Sm2Fe17 particles during the process of hydrogenation.The Sm2Fe17Nx powder treaed by hydrogenation thennitrogenization has the higher content of N and the better intrinsic and technological magnetic properties than that treated by nitrogenization directly. | ZHANG Shaoying, TAI Lichi, CUI LiyaCentral Iron and Steel Research Institute, Beijing, China | 1994 | Acta Metallurgica Sinica(English Letters)1994，7，1： | 0 |
| 19 | PRODUCT GENE REPRESENTATION AND ACQUISITION METHOD BASED ON POPULATION OF PRODUCT CASES显示文摘产品基因的表示和获得是在产品的一个关键问题进化设计。从产品盒子的一张人口的产品基因表示和获得的新方法论被建议,并且为产品的方法论进化设计基于产品的一张人口,盒子被认识到。由适当地根据它的产品种类分类产品盒子,产品盒子的人口被划分,一个模型被建立。计划设计的知识被提取并且作为函数库,原则库,和结构底提出了,它然后被联合形成产品基因。随后,产品基因树被面向对象的方法创造并且代表。然后把这个方法与进化推理技术相结合,产品的一个聪明、自动的进化计划图案基于产品盒子的人口被认识到。这个设计方法将在处理知识明确的表达,累积,和复用,并且在探讨在传统的设计获得设计知识的困难是有用的。另外,在基于盒子的推理的用手的盒子改编和更改的劣势能被消除。而且由在产品功能,原则,和结构等等的多重层次和方面优化设计计划,在计划设计的创造性的水平能被改进。 | TAI Ligang ZHONG Tingxiu MIAOZhonghua CUI Qifeng | 2007 | Chinese Journal of Mechanical Engineering2007，20，6： | 0 |
| 20 | SecReT6 update:a comprehensive resource of bacterial TypeⅥSecretion Systems显示文摘TypeⅥSecretion System(T6SS)plays significant roles in microbial activities via injecting effectors into adjacent cells or environments.T6SS increasingly gained attention due to its important influence on pathogenesis,microbial competition,etc.T6SS-associated research is explosively expanding on numerous grounds that call for an efficient resource.The SecReT6 version3 provides comprehensive information on T6SS and the interactions between T6SS and T6SS-related proteins such as T6SS regulators and T6SS effectors.To assist T6SS researches like microbial competition and regulatory mechanisms,SecReT6 v3developed online tools for detection and analysis of T6SS and T6SS-related proteins and estimation of T6SS-dependent killing risk.We have identified a novel T6SS regulator and T6SS-dependent killing capacity in Acinetobacter baumannii clinical isolates with the aid of SecReT6 v3.17,212 T6SSs and plentiful T6SS-related proteins in 26,573 bacterial complete genomes were also detected,analyzed and incorporated into the database.The database is freely available at http://gffzz9e3aa14eb2fb472eskwonu6fuuwow6ox5.ffgz.tsg.suse.edu.cn/SecReT6/. | Jianfeng Zhang Jiahao Guan Meng Wang Gang Li Marko Djordjevic Cui Tai Hui Wang Zixin Deng Zhaoyan Chen Hong-Yu Ou | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
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