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| 1 | Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current显示文摘Activin A,which was first described in 1986,has been shown to maintain hippocampal neuronal survival.Activin A increases intracellular free Ca2+ via L-type Ca2+ channels.Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion.The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period,and that activin A was shown to increase voltage-gated Na+ current(INa) in Neuro-2a cells,which was recorded by patch clamp technique.The present study revealed a novel mechanism for activin A,as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase. | Jingyan Ge Yinan Wang Haiyan Liu Fangfang Chen Xueling Cui Zhonghui Liu | 2010 | Neural Regeneration Research2010，5，19： | 4 |
| 2 | Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells显示文摘Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. | Jingyan Ge Yinan Wang Ye Feng Haiyan Liu Xueling Cui Guixiang Tai Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，2： | 4 |
| 3 | A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo显示文摘Activin A,转变生长因素贝它(TGF-) 的一个多功能的因素总科,被 microglia 和巨噬细胞主要生产,并且它的反煽动性并且支持 inflammatory 活动是与巨噬细胞功能有关的两个。然而,在 vivo 的剩余的巨噬细胞上的 activin A 的直接效果仍然保持不清楚。在现在的学习,结果显示出那 activin A 不仅不增加了并且 IL-1 版本,而且在 vitro 并且在 vivo 的鼠标腹巨噬细胞的支持的吞噬细胞的能力,而它没影响 MHC 我和 MHC II 表示。而且,我们显著地发现那 activin A upregulated CD14 和 CD68 的表情,成熟巨噬细胞的标记,在在 vitro 并且在 vivo 的巨噬细胞的表面上。这些数据建议 activin A 能在 vitro 并且在 vivo 导致主要巨噬细胞成熟,但是不能经由调整涉及抗原的表示的 MHC 分子的表示触发获得的有免疫力的反应。 | Yinan Wang Xueling Cui Guixiang Tai Jingyan Ge Nan Li Fangfang Chen Fang Yu Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 4 | Intracellular effects of prodrug-like wortmannin probes显示文摘Wortmannin, a known inhibitor of phosphoinositide 3-kinases(PI3 Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3 Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site respectively. MTT assay first confirmed that self-activating probes have better inhibition potency and biotin enhanced their cancer cell uptake. Further experiments showed most of probes can target PI3 K/Akt/mTOR pathway with prolonged turn-over time. Protein profiling and pull-down results were observed that the derivatives not only labelled four PI3 Ks with selectivity, but also engaged in covalent interactions with numerous cellular proteins which could be the major reason of their high toxicity. | Shasha Ying Shubo Du Jia Dong Bi Xuan Ng Chengwu Zhang Lin Li Jingyan Ge Qing Zhua | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 5 | The use of click chemistry in the emerging field of catalomics 显示文摘 | KURUNAKARAN A K SHI Haibin GE Jingyan | 2010 | Organic & Biomolecular Chemistry2010，8，8： | 1 |
| 6 | Recent advances in construction of small molecule-based fluorophoredrug conjugates显示文摘As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good sensitivity.The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in vivo.In this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery. | Wenjie Lang Chaonan Yuan Liquan Zhu Shubo Du Linghui Qian Jingyan Ge Shao Q Yao | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 0 |
| 7 | Construction and application of LHAASO data processing platform显示文摘Purpose The LHAASO project collects trillions of cosmic ray events every year,generating about 10 PB of raw data annually,which brings big challenges for data processing platform.Method The LHAASO data processing platform is built to handle such a large amount of data,which is composed of some subsystems such as data transfer,data storage,high throughput computing and metadata management.Results and conclusions The platform was under construction since 2018 and has been working well since 2021.In this paper,the details of the design,implementation and performance of the data processing platform are presented. | Yaodong Cheng Haibo Li Yujiang Bi Jingyan Shi Shan Zeng Hongmei Zhang Ge Ou Mengyao Qi Qiuling Yao Yaosong Cheng | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
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