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| 1 | NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors显示文摘胶体的黄金(Au ) ,容忍得好的 nanomaterial,当前在 nanomedicine 为几个应用程序被利用。我们显示出与包含 Asn-Gly-Arg (NGR ) 的新奇肿瘤家肽标注的那金 nanoparticles, CD13 的 ligand 由肿瘤 neovasculature 表示了,能为 cytokine 交货作为搬运人被利用到肿瘤。生物化学、功能的研究证明为金 functionalization 使用的 NGR 分子的支架 / 连接器为 CD13 识别是批评的。用忍受纤维肉瘤的老鼠,标注 NGR 的 nanodrugs 能交付极其低,还肿瘤坏死因素(TNF ) 的 pharmacologically 活跃的剂量, anticancer cytokine,到没有毒性的证据的肿瘤。机械学的研究证实指向的 CD13 是药交货的主要机制并且排除了对 NGR deamidation 作为结果的指向的 integrin 的一个主要角色,产生 isoAsp-Gly-Arg (isoDGR ) 的降级反应 integrin ligand。原则上,标注 NGR 的金 nanoparticles 罐头为癌症治疗为 single-cytokine 或 multi-cytokine 交货被用作一个新奇平台到肿瘤 endothelial 房间。 | Flavio Curnis Martina Fiocch Angelina Sacchi Alessandro Gori Anna Gasparri Angelo Corti | 2016 | Nano Research2016，9，5： | 5 |
| 2 | Trans-Septal Catheterization in the Electrophysiology Laboratory显示文摘 | Roberto De Ponti Riccardo Cappato Antonio Curnis Paolo Della Bella Luigi Padeletti Antonio Raviele Massimo Santini Jorge A. Salerno-Uriarte | 2006 | Journal of the American College of Cardiology2006，，5： | 2 |
| 3 | Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration显示文摘 | SACCHI A CORTI A | 2002 | J Clin Invest2002，110，4： | 1 |
| 4 | Enhancement of tumor necrosis factor an antitumor immuno-therapeutic properties by targeted delivery to aminopeptidase N(CD13)显示文摘 | Curnis F Sacchi A Borgna L | 2000 | Nat Biotechnol2000，18，： | 1 |
| 5 | Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor alpha (NGR-TNF) and doxorubicin显示文摘 | Sacchi A Gasparri A Curnis F | 2004 | Cancer Res2004，64，19： | 1 |
| 6 | Implantable Cardioverter-Defibrillator Therapy for Prevention of Sudden Death in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia显示文摘 | Domenico Corrado Loira Leoni Mark S. Link Paolo Della Bella Fiorenzo Gaita Antonio Curnis Jorge Uriarte Salerno Diran Igidbashian Antonio Raviele Marcello Disertori Gabriele Zanotto Roberto Verlato Giuseppe Vergara Pietro Delise Pietro Turrini Cristina Ba | 2003 | Circulation: Journal of the American Heart Association2003，，25： | 1 |
| 7 | Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration显示文摘 | Curnis F Sacchi A Corti A | 2002 | Journal of Clinical Investigation2002，110，4： | 1 |
| 8 | Carbohydrate antigen 125:a new biomarker in heart failure显示文摘 | Vizzardi E D'Aloia A Curnis A | 2013 | Cardiol Rev2013，21，1： | 1 |
| 9 | Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells显示文摘 | Curnis F Arrigoni G Sacchi A | 2002 | Cancer Res2002，62，： | 1 |
| 10 | Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif显示文摘 | Colombo G Curnis F De Mori GM | 2002 | J Biol Chem2002，277，47： | 1 |
| 11 | Carbohydrate antigen 125:a new biomarker in heart failure显示文摘 | Vizzardi E D'Aloia A Curnis A | 2013 | Cardiol Rev2013，21，： | 1 |
| 12 | Targeted delivery of IFN gamma to tumor vessels uncouples antitumor from counterregulatory mechanisms显示文摘 | Curnis F Gasparri A Sacchi A Cattaneo A Magni F Corti A | 2005 | Cancer Res2005，65，： | 1 |
| 13 | Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from eounterregulatory mechanisms显示文摘 | Curnis F Gasparri A Sacchi A | 2005 | Cancer Res2005，65，7： | 1 |
| 14 | Isoaspartate -dependent molecular switches for in tegrin -ligand recognition 显示文摘 | Corti A Curnis F | 2011 | J Cell Sci2011，124，4： | 1 |
| 15 | Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)显示文摘 | Curnis F Sacchi A Borgna L | 2000 | Nat Biotechnol2000，18，11： | 1 |
| 16 | Coupling tumornecrosis factor-α with cry integrin ligands improves its antineoplastic activity显示文摘 | Curnis F Gasparri A Sacchi A | 2004 | Cancer Res2004，64，2： | 1 |
| 17 | Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif 显示文摘 | COLOMBO G CURNIS F DE MORI GM | 2002 | J Biol Chem2002，277，47： | 1 |
| 18 | Long-Term Prognostic Value of CA 125 Serum Levels in Mild to Moderate Heart Failure Patients显示文摘 | Enrico Vizzardi Antonio D'Aloia Natalia Pezzali Silvia Bugatti Antonio Curnis Livio Dei Cas | 2012 | Journal of Cardiac Failure2012，，1： | 1 |
| 19 | Antiarrhythmic Effect of Reverse Ventricular Remodeling Induced by Cardiac Resynchronization Therapy显示文摘 | Luigi Di Biase Maurizio Gasparini Maurizio Lunati Massimo Santini Maurizio Landolina Giuseppe Boriani Antonio Curnis Mario Bocchiardo Antonio Vincenti Alessandra Denaro Sergio Valsecchi Andrea Natale Luigi Padeletti | 2008 | Journal of the American College of Cardiology2008，，18： | 1 |
| 20 | Coupling tumor necrosis factor-alpha withalphaV integrin ligands improves its antineoplastie activity显示文摘 | Curnis F Gasparri A Saechi A | 2004 | Caneer Res2004，64，2： | 1 |
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