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| 1 | Enhanced second-harmonic generation from two-dimensional MoSe_(2) on a silicon waveguide显示文摘Two-dimensional transition-metal dichalcogenides(TMDCs)with intrinsically broken crystal inversion symmetry and large secondorder nonlinear responses have shown great promise for future nonlinear light sources.However,the sub-nanometer monolayer thickness of such materials limits the length of their nonlinear interaction with light.Here,we experimentally demonstrate the enhancement of the second-harmonic generation from monolayer MoSe_(2) by its integration onto a 220-nm-thick silicon waveguide.Such on-chip integration allows for a marked increase in the interaction length between the MoSe_(2) and the waveguide mode,further enabling phase matching of the nonlinear process.The demonstrated TMDC–silicon photonic hybrid integration opens the door to second-order nonlinear effects within the silicon photonic platform,including efficient frequency conversion,parametric amplification and the generation of entangled photon pairs. | Haitao Chen Vincent Corboliou Alexander S Solntsev Duk-Yong Choi Maria A Vincenti Domenico de Ceglia Costantino de Angelis Yuerui Lu Dragomir N Neshev | 2017 | Light(Science & Applications)2017，6，1： | 7 |
| 2 | Hepatitis C virus and metabolic disorder interactions towards liver damage and atherosclerosis显示文摘Hepatitis C virus(HCV)is one of the main causes of liver disease worldwide,and alterations of glucose metabolism have reached pandemic proportions in western countries.However,the frequent coexistence between these two conditions is more than simply coincidental,since HCV can induce insulin resistance through several mechanisms.Indeed,the virus interferes with insulin signaling both directly and indirectly,inducing the production of pro-inflammatory cytokines.Furthermore,the entire viral life cycle has strict interconnections with lipid metabolism,and HCV is responsible for a'viral'steatosis which is frequently superimposed to a'metabolic'one.Several evidences suggest that HCV-induced metabolic disorders contribute both to the evolution of liver fibrosis and,likely,to the progression of the other disorders which are typically associated with altered metabolism,in particular atherosclerosis.In the present review,we will examine in depth the links between HCV infection and insulin resistance,liver steatosis and diabetes,and analyze the impact of these interactions on the progression of liver fibrosis and atherosclerosis.Special attention will be focused on the highly debated topic of the relationship between HCV infection and cardiovascular disease.The available clinical literature on this item will be broadly reviewed and all the mechanisms possibly implied will be discussed. | Umberto Vespasiani-Gentilucci Paolo Gallo Antonio De Vincentis Giovanni Galati Antonio Picardi | 2014 | World Journal of Gastroenterology2014，20，11： | 5 |
| 3 | Hepatitis C treatment in the elderly:New possibilities and controversies towards interferon-free regimens显示文摘Due to the progressive aging of the hepatitis C virus(HCV) population which have acquired the infection during its maximum spread after the Second World War, the management of the elderly HCV-infected patient is emerging as a hot topic. Unfortunately, although it is recognized that the progression of HCV-related liver disease gets faster with aging, and that even extrahepatic manifestations of HCV infection are probably worse in the elderly, till now, treatment attempts in this population have been significantly limited by the wellknown contraindications and side effects of interferon(IFN). The arrival of several new anti-HCV drugs, and the possibility to combine them in safe and effective anti-viral regimens, is relighting the hope of a cure for many elderly patients who had been cut out of IFN-based treatments. However, although these new regimens will be certainly more manageable, it should be underscored that IFN-free doesn't mean free from any contraindication or side-effect. Moreover, one issue which promises to become central is that of the possible interactions between antiviral therapy and the multiple drugs frequently assumed by elderly patients because of comorbidities. In this review, we will revise the epidemiology pointing to HCV as an infection of the elderly, the evidences that HCV harms the health of the aged patient more than that of the young one, and the available experiences of HCV treatment in the elderly with the 'old' IFN-based regimens and with the newer drugs. We will conclude that the availability of IFNfree regimens should prompt us to change our mind and consider a significantly larger number of possible candidates among elderly patients, who would take significant advantage from viral eradication. Rather than the anagraphic age, drug-drug interactions and, mainly in case of economic restrictions, an evaluation of life expectancy dependent on liver disease with respect to that dependent on comorbidities, are likely to be the key issues guiding treatment indication in the next future. The sooner we will change our mind with respect to an a priori obstacle for anti-HCV treatment in the elderly, the sooner we will begin to spare many aged HCV patients from avoidable liver-related complications. | Umberto Vespasiani-Gentilucci Giovanni Galati Paolo Gallo Antonio De Vincentis Elisabetta Riva Antonio Picardi | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 4 | Exhaled breath analysis in hepatology: State-of-the-art and perspectives显示文摘Liver disease is characterized by breath exhalation of peculiar volatile organic compounds(VOCs).Thanks to the availability of sensitive technologies for breath analysis,this empiric approach has recently gained increasing attention in the context of hepatology,following the good results obtained in other fields of medicine.After the first studies that led to the identification of selected VOCs for pathophysiological purposes,subsequent research has progressively turned towards the comprehensive assessment of exhaled breath for potential clinical application.Specific VOC patterns were found to discriminate subjects with liver cirrhosis,to rate disease severity,and,eventually,to forecast adverse clinical outcomes even beyond existing scores.Preliminary results suggest that breath analysis could be useful also for detecting and staging hepatic encephalopathy and for predicting steatohepatitis in patients with nonalcoholic fatty liver disease.However,clinical translation is still hampered by a number of methodological limitations,including the lack of standardization and the consequent poor comparability between studies and the absence of external validation of obtained results.Given the low-cost and easy execution at bedside of the new technologies(e-nose),larger and well-structured studies are expected in order to provide the adequate level of evidence to support VOC analysis in clinical practice. | Antonio De Vincentis Umberto Vespasiani-Gentilucci Anna Sabatini Raffaele Antonelli-Incalzi Antonio Picardi | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 5 | Target Therapies in Pancreatic Carcinoma显示文摘 | Nicola Silvestris Antonio Gnoni Anna Elisabetta Brunetti Leonardo Vincenti Daniele Santini Giuseppe Tonini Francesca Merchionne Evaristo Maiello Vito Lorusso Patrizia Nardulli Amalia Azzariti Michele Reni | 2014 | Current Medicinal Chemistry2014，，8： | 2 |
| 6 | IL- 1 induces collagenase- 13(MMP- 13)promoter activity in stably transfected chondrocytic cells:requirement for Runx- 2 and actiation by p38 MAPK and JNK pathways显示文摘 | Mengshol JA Vincenti MP Brinckerhoff CE | 2001 | Nucleic Acids Res2001，29，21： | 1 |
| 7 | Evaluation of the effect of tofacitinib exposure on outcomes in kidney transplant patients显示文摘 | Vincenti F Silva HT Busque S | 2015 | Am J Transplant2015，15，6： | 1 |
| 8 | Low- cost semirigid ureteroscopy is effective for ureteral stones:experience of a single high volume center显示文摘 | Giulianelli R Gentile BC Vincenti G | 2014 | Arch Ital Urol Androl2014，86，2： | 1 |
| 9 | Photocatalytic degradation on monuron in aqueous TiO2 dispersions Environ 显示文摘 | PRAMAUOR E VINCENTI M AUGUGLLARO V | 1993 | Sci Technol1993，27，： | 1 |
| 10 | From the Basic Mechanics of Orthogonal Metal Cutting toward the Identification of the Constitutive Equation显示文摘 | Tounsi N Vincenti J Otho A | 2002 | In- ternational Journal of Machine Tool & Manufac- ture2002，42，12： | 1 |
| 11 | Photocatalytic degradation on monuron in aqueous TiO2 dispersions 显示文摘 | Pramauro E Vincenti M Augugllaro V | 1993 | Environ Sci Technol1993，27，9： | 1 |
| 12 | Interleukin - 2 receptor blockade with daclizunab to prevent acute rejection in renap transplantation显示文摘 | Vincenti F Kirkman R Light S | 1998 | N Engl med1998，338，： | 1 |
| 13 | Cochlear implantation and Cogan syndrome显示文摘 | Pasanisi E Vincenti V Bacciu A | 2003 | Otology & Neurotology2003，24，： | 1 |
| 14 | EpsteinBarr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b显示文摘 | Anastasiadou E Boccellato F Vincenti S | | 0，，09： | 1 |
| 15 | A decade of progress in kidney transplantation显示文摘 | Vincenti F | 2004 | Transplantation2004，77，9： | 1 |
| 16 | Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis显示文摘 | A. Vacca D. Ribatti M. Iurlaro A. Albini M. Minischetti F. Bussolino A. Pellegrino R. Ria M. Rusnati M. Presta V. Vincenti M. G. Persico F. Dammacco | 1998 | International Journal of Clinical & Laboratory Research1998，，1： | 1 |
| 17 | A long-term comparison of tacrolimus(FK506)and cyclosporine in kidney transplantation:evidence for improved allograft survival at five years显示文摘 | Vincenti F Jensik SC Filo RS | 2002 | Transplantation2002，73，5： | 1 |
| 18 | Results of an international,randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus显示文摘 | Vincenti F Friman S Scheuermann E | 2007 | Am J Transplant2007，7，6： | 1 |
| 19 | Photocatalytic degradation on monuron in aqueous TiO2 dispersions 显示文摘 | Pramauro E Vincenti M Augugllaro V | 1993 | Environ Sci Technol1993，27，： | 1 |
| 20 | Interleukin-1 induction of col agenase 3(matrix metal oproteinase 13) gene expression in chon drocytes requires p38,c-Jun N-terminal kinase,and nuclear factor kappaB:differential regulation of col agenase 1 and col agenase3显示文摘 | Menqshol JA Vincenti MP Coon CI | | 0，，04： | 1 |
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