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| 1 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 2 | Tracking changes following spinal cord injury:insights from neuroimaging显示文摘 | Freund P Curt A Friston K Thompson A | 2013 | Neuroscientist2013，19，2： | 1 |
| 3 | Recovery from a spinal cord injury: significance of compensation, neural plasticity, and repair 显示文摘 | Curt A Van Hedel HJ Klaus D | 2008 | J Neurotrauma2008，25，6： | 1 |
| 4 | Rehabilitation in spine and spinal cord trauma显示文摘 | Labruyère R Agarwala A Curt A | 2010 | Spine2010，35，21： | 1 |
| 5 | Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel:spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials显示文摘 | Fawcett JW Curt A Steeves JD | | 0，，： | 1 |
| 6 | Clinical value of combined electophysiological and urodynamic recordings to assess sexual disorders in spinal cord injured men显示文摘 | Schmid DM Curt A Hauri D | 2003 | Neurourol Urodyn2003，22，4： | 1 |
| 7 | Changes of non-affected up per limb cortical representation in paraplegic patients as assessed by fMRI显示文摘 | Curt A Alkadhi H Crelier GR | 2002 | Brain2002，125，11： | 1 |
| 8 | Validation of the weight-drop contusion model in rats:a comparative study of human spinal cord injury显示文摘 | Metz GA Curt A van de Meent H | | 0，，01： | 1 |
| 9 | Changes of non-affected upper limb cortical representation in paraplegic patients as as sessed by fMRI显示文摘 | Curt A Alkadhi H Crelier GR | 2002 | Brain2002，125，25： | 1 |
| 10 | Impact of cancer-related fatigue on the lives of patients:New findings from the fatigue coalition显示文摘 | Curt G A Breitbart W Cella D | 2000 | Oncologist2000，5，5： | 1 |
| 11 | Cellular transplants in China:observational study from the largest human experiment in chronic spinal cord injury显示文摘 | Dobkin BH Curt A Guest J | | 0，，01： | 1 |
| 12 | 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (Updating the 2006 Guideline): a report of the American College of Cardiology Foundation/American Heart association Task Force on Pracitce Guidelines显示文摘 | Wann L S Curt is A B January C T | 2011 | Heart Rhythm2011，1，8： | 1 |
| 13 | Traumatic cervical spinal cord in jury: ralation between somatusensory evoked potentials, neurological deficit, and hand function 显示文摘 | Curt A Dietz V | 1996 | Arch Phys Mad Rehabil1996，77，： | 1 |
| 14 | Synthesis and Characterization of Amorphous Si2 N20 显示文摘 | Weeren R Leone E A Curt'an S | 1994 | Journal of the American Ceramic Society1994，77，10： | 1 |
| 15 | Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP pan el: spontaneous recovery after spinal cord injury and statistical power needed for therapeutie clinical trials显示文摘 | Fawcett JW Curt A Steeves JD | 2007 | Spinal Cord2007，45，3： | 1 |
| 16 | Clinical value of F-wave recordings intraumatic cervical spinal cord injury显示文摘 | Curt A Keck ME Dietz V | 1997 | Electroencephalogram Clin Neurophysiol1997，105，： | 1 |
| 17 | Arikle paresis in incom- plete spinal cord injury: relation to corticospinal conductivi- ty and ambulatory capacity显示文摘 | Wirth B van Hedel H J Curt A | 2008 | J Clin Neurophysiol2008，25，4： | 1 |
| 18 | Reorganization and preservation of motor control of the brain in spinal eord injury:a systematic review显示文摘 | Kokotilo K J Eng J J Curt A | 2009 | J Neurotrauma2009，26，： | 1 |
| 19 | Holocene climate variability显示文摘 | MAYEWSKI P A ROHLING E E CURT STAGER J | 2004 | Quaternary Research2004，62，： | 1 |
| 20 | Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption显示文摘The etiology of most cases of idiopathic bile acid malabsorption (IBAM) is unknown. In this study, a Swedish family with bile acid malabsorption in three consecutive generations was screened for mutations in the ileal apical sodium-bile acid cotransporter gene (ASBT; gene symbol, SLC10A2) and in the genes for several of the nuclear receptors known to be important for ASBT expression: the farnesoid X receptor (FXR) and peroxisome proliferator activated receptor alpha (PPARa). The patients presented with a clinical history of idiopathic chronic watery diarrhea, which was responsive to cholestyramine treatment and consistent with IBAM. Bile acid absorption was determined using 75Se-homocholic acid taurine (SeHCAT); bile acid synthesis was estimated by measuring the plasma levels of 7a-hydroxy-4-cholesten-3-one (C4). The ASBT, FXR, and PPARa genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism (SSCP), denaturing HPLC, and direct sequencing. No ASBT mutations were identified and the ASBT gene did not segregate withthe bile acid malabsorption phenotype. Similarly, no mutations or polymorphisms were identified in the FXR or PPARa genes associated with the bile acid malabsorption phenotype. These studies indicate that the intestinal bile acid malabsorption in these patients cannot be attributed to defects in ASBT. In the absence of apparent ileal disease, alternative explanations such as accelerated transit through the small intestine may be responsible for the IBAM. | Marco Montagnani Anna Abrahamsson Cecilia Glman Gsta Eggertsen Hanns-Ulrich Marschall Elisa Ravaioli Curt Einarsson Paul A Dawson | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
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