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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Inter-limb coordination in swimming: Effect of speed and skill level显示文摘 | SEIFERT L LEBLANC H CHOLLET D | 2010 | Human movement sci- ence2010，29，1： | 1 |
| 3 | Biomechanical analysisof the breaststroke start显示文摘 | Seifert L Vantorre J Chollet D | 2007 | International journalof sports medicine2007，28，11： | 1 |
| 4 | Differentprofiles of the aerial start phase in front crawl显示文摘 | Seifert L Vantorre J Chollet D | 2010 | The Journal of Strength &- Conditioning Research2010，24，2： | 1 |
| 5 | Clini-cal risk factors for placenta previa-placenta accreta 显示文摘 | Miller D A Chollet T A Goodwin T M | 1997 | AM J Obstet Gyneco1997，177，1： | 1 |
| 6 | The effect of combined self- and expert-modelling on the performaneeof the double leg circle on the pommel horse 显示文摘 | L Baudry D Leroy D Chollet | 2006 | Journal of Sports Sciences2006，24，10： | 1 |
| 7 | Treatment of advanced colorectal and gastric adenocarcinoma with 5-fluorouracil and highdose folic acid 显示文摘 | Machover D Goldschmidt E Chollet P | 1986 | J Clin Oncol1986，4，4： | 1 |
| 8 | A new index of flat breaststroke propulsion: a comparison of elite men and women显示文摘 | L SEIFERT D CHOLLET | 2005 | J Sports Sci2005，23，3： | 1 |
| 9 | Effect of swimming velocity on arm coordination in the front crawl: a dynamic analysis显示文摘 | L SEIFERT D CHOLLET B G BARDY | 2004 | J Sports Sci2004，22，： | 1 |
| 10 | Czrrier-medi- ated uptake and phloem systemy of a 350-Dahon Chlori- catde xenobihic with an a-amino acid function 显示文摘 | Grandon D Chollet J F Fauchuer M | 2001 | Plant Physiol2001，125，： | 1 |
| 11 | Stroking characteristic variations in the 100-m freestyle for male swimmers of differing skill 显示文摘 | CHOLLET D PELAYO P DELAPLACE C | 1997 | Perceptual Motor Skills1997，85，1： | 1 |
| 12 | Clinical risk fac- tors for placenta previa -placenta accreta显示文摘 | MILLER D A CHOLLET J A GOODWIN T M | 1997 | Am J Obstet Gyne- col1997，177，1： | 1 |
| 13 | Comparative analysis of 100m and 200m events in the four strokes in top level swimmers显示文摘 | CHOLLET D PELAYO P TOURNY C | 1996 | J Human Move Studies1996，31，1： | 1 |
| 14 | Text-independent speaker verification state of the art and challenges显示文摘 | Dijona P D Asmaa E H Gerard Chollet | 2007 | LNCS2007，，： | 1 |
| 15 | Differences in spatial - temporal parameters and spatial-temporal parametersandarm-legcoordination in butterfly stroke as a function of race pace, skill and gender显示文摘 | L Seifert L Boulesteix D Chollet | 2008 | Human Movement Science2008，27，： | 1 |
| 16 | Effect of gender on the adaptation of arm coordination in front crawl显示文摘 | SEIFERT L BOULESTEIX L CHOLLET D | 2004 | Int J Sports Med2004，25，3： | 1 |
| 17 | Arm coordination symmetry and breathing effect in front crawl显示文摘 | SEIFERT L CHOLLET D ALLARD P | 2005 | Human Move Sci2005，24，2： | 1 |
| 18 | Effect of swimming velocity on arm coordination in the front crawl:a dynamic analysis 显示文摘 | SEIFERT L CHOLLET D BARDY B | 2004 | J Sports Sci2004，22，： | 1 |
| 19 | Clinical risk factors for placenta previa-placenta accrete显示文摘 | Miller D A Chollet J A Goodwin T M | | 0，，02： | 1 |
| 20 | Blood and brain magnesium in inbred mice and their correlation with sleep quality 显示文摘 | Chollet D Franken P Raffin Y | 2000 | Am J Physiol Regul Integr Comp Physiol2000，279，6： | 1 |
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