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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Current Status of Gastrointestinal Carcinoids显示文摘 | Irvin M. Modlin Mark Kidd Igor Latich Michelle N. Zikusoka Michael D. Shapiro | 2005 | Gastroenterology2005，，6： | 2 |
| 3 | A Toxicity Index of Skin and Wound Cleansers Used on In Vitro Fibroblasts and Keratinocytes显示文摘 | Judy R. Wilson John G. Mills Irvine D. Prather S. Dan Dimitrijevich | 2005 | Advances in Skin & Wound Care2005，，7： | 1 |
| 4 | Clinical and Microbiological Characteristics of Fungal Keratitis in the United States, 2001–2007: A Multicenter Study显示文摘 | Lisa J. Keay Emily W. Gower Alfonso Iovieno Rafael A. Oechsler Eduardo C. Alfonso Alice Matoba Kathryn Colby Sonal S. Tuli Kristin Hammersmith Dwight Cavanagh Salena M. Lee John Irvine R. Doyle Stulting Thomas F. Mauger Oliver D. Schein | 2011 | Ophthalmology2011，，5： | 1 |
| 5 | Glaucoma Patients’ Assessment of Their Visual Function and Quality of Life显示文摘 | Henry D. Jampel Arthur Schwartz Irvin Pollack Donald Abrams Howard Weiss Rhonda Miller | 2002 | Journal of Glaucoma2002，，2： | 1 |
| 6 | Finite strain theories and comparisons with seismological data显示文摘 | F. D. Stacey B. J. Brennan R. D. Irvine | 1981 | Geophysical Surveys1981，，3： | 1 |
| 7 | An Analysis of Rare Carcinoid Tumors: Clarifying These Clinical Conundrums显示文摘 | Irvin M. Modlin M.D. Ph.D. Michael D. Shapiro B.S. Mark Kidd Ph.D | 2005 | World Journal of Surgery2005，，1： | 1 |
| 8 | Twenty years of experience with laparoscopic antireflux surgery显示文摘 | C. Engstr?m W. Cai T. Irvine P. G. Devitt S. K. Thompson P. A. Game J. R. Bessell G. G. Jamieson D. I. Watson | 2012 | Br J Surg2012，，10： | 1 |
| 9 | 直视骄阳:征服死亡恐惧显示文摘两千无百多年前,孔子叹曰:“未知生,焉知死?”一语惊醒梦中人。可是,孔子的弟予们记下了一子在川上曰:“逝者如斯大,不舍昼夜。” | Irvin D. Yalom 张亚 | 2018 | 心理与健康2018，0，3： | 0 |
| 10 | 2-13 Stellar Reaction Rate of the 14O(α, p)17F显示文摘Proton resonant states in 18Ne have been investigated by the resonant scattering of 17F+p with a 17F beambombarding a thick H2 gas target. Several resonances have been observed. In particular, the astrophysically crucialstate 6.15 MeV was observed as a spin-parity assignment of 1?? with high statistics. The groove-like structureobserved in this work is completely different with previous peak one[1]. The confirmation of 1?? on a firm groundclarified this significant discrepancy. In addition, a new state was observed at Ex = 6.85 MeV with a tentativespin assignment of 0, which could be the mirror state of 6.88 MeV, 0?? in 18O, or a bandhead state (0+) of thesix-particle four-hole (6p-4h) band[2,3]. The resonant parameters have been determined by an R-matrix analysis ofthe excitation functions. | Hu Jun He Jianjun Xu Shiwei H. Yamaguchi Ma Peng D. Kahl Su Jun Wang Hongwei T. Nakao Y. Wakabayashi J. Y. Moon T. Teranishi H. S. Jung T. Hashimoto A. Chen D. Irvine S. Kubono | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | PNAS:科学家或成功实现利用基因疗法来治疗阿尔兹海默氏症显示文摘日前,来自帝国理工学院的研究人员通过利用病毒将特殊的基因片段运输到小鼠大脑中,从而成功抑制小鼠患阿尔兹海默氏症,相关研究刊登于国际杂志PNAS上,该研究或为后期开发治疗诸如阿尔兹海默氏症等神经性疾病的新型疗法提供思路。 | Loukia Katsouri Yau M. Lim Katrin Blondrath Ioanna Eleftheriadou Laura Lombardero Amy M. Birch Nazanin Mirzaei Elaine E. Irvine Nicholas D. Mazarakis Magdalena Sastre | 2017 | 现代生物医学进展2017，17，4： | 0 |
| 12 | 2 - 20 Investigation for Resonant Scattering of 17F+p显示文摘 | Hu Jun He Jianjun Xu Shiwei H. Yamaguchi Ma Peng K. David Su Jun Wang Hongwei T. Nakao Y. Wakabayashi J. Y. Moon T. Teranishi H. S. Jung T. Hashimoto A. Chen D. Irvine S. Kubono | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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