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| 1 | Significance of glacio-morphological factors in glacier retreat:a case study of part of Chenab basin,Himalaya显示文摘A study has been carried out in part of Chenab basin,Himalaya to understand the relationship between glacio-morphological factors and change in glacial area. Initially change in areal extent of glaciers was derived for two time frames(1962-2001/02 and 2001/02-2010/11). The study comprised of 324 glaciers for the monitoring period of 1962-2001/02 for,which 11% loss in glacial area was observed. Two hundred and thirty-eight glaciers were further monitored between 2001/02 and 2010/11. These glaciers showed an area loss of 1.1%. The annual deglaciation has been found to be higher during the period of 1962-2001/02 compared to 2001/02-2010/11. The spatial and temporal variability in deglaciation was also addressed usingglacio-morphic parameters. Area,length,percentage of debris cover,and various elevation parameters of glaciers were observed to have significant controls on relationships to the rate of glacial shrinkage. Largerarea and longer glaciers show a lower percentage of retreat than smaller and shorter ones. Moreover,glaciers located at lower altitudes and having gentle slopes show more area retreat. The results of area retreat in debris covered and debris free glaciers supports that the glaciers covered by debris retard ice melting at some extent. 158 glaciers were observed having no debris cover,and these exhibit 14% of loss in surface area. In glaciers having 40% debris cover,8% of deglaciation was observed. The glaciers located below equilibrium line altitude(ELA) have experienced 4.6% of deglaciation for the time frame 2001/02 – 2010/11 whereas it was found to be 1.1% for the glaciers occurring above ELA. However,theorientation of glaciers did not show any considerable influence on glacial change based on hypothesis. | Rupal M.BRAHMBHATT I.M.BAHUGUNA B.P RATHORE Anil V.KULKARNI Rajesh D.SHAH A.S.RAJAWAT Jeffrey S.KARGEL | 2017 | Journal of Mountain Science2017，14，1： | 3 |
| 2 | An improved synthesis of enantiomerically pure RWJ 69442, a development candidate for the treatment of benign prostatic hyperplasia显示文摘 | Gee‐HongKuo CatherineProuty William V.Murray Rekha D.Shah | 2009 | Journal of Heterocyclic Chemistry2009，，4： | 1 |
| 3 | Understanding lactic acidosis in paracetamol (acetaminophen) poisoning显示文摘 | Anoop D.Shah David M.Wood Paul I.Dargan | 2010 | British Journal of Clinical Pharmacology2010，，： | 1 |
| 4 | Prospective evaluation of health status, quality of life and clinical outcomes following implantable defibrillator generator exchange显示文摘BACKGROUND Little is known about health status and quality of life(QoL)after implantable cardioverter-defibrillator(ICD)generator exchange(GE).METHODS We prospectively followed patients undergoing first-time ICD GE.Serial assessments of health status were performed by administering the 36-Item Short Form Survey(SF-36).RESULTS Mean age was 67.5±14.3 years,left ventricle ejection fraction(LVEF)was 36.5%±15.0%and over 40%of the cohort had improved LVEF to>35%at the time of GE.SF-36 scores were significantly worse in physical/general health domains compared to domains of emotional/social well-being(P<0.001 for each comparison).Physical health scores were significantly worse among those with medical comorbidities including diabetes,chronic obstructive pulmonary disease and atrial fibrillation.Mean follow-up was 1.6±0.5 years after GE.Overall SF-36 scores remained stable across all domains during follow-up.Survival at 3 years post-GE was estimated at 80%.Five patients died during follow-up and most deaths were adjudicated as non-arrhythmic in origin.Four patients experienced appropriate ICD shocks after GE,three of whom had LVEF which remains impaired LVEF(i.e.,<35%)at the time of GE.CONCLUSION Patients undergoing ICD GE have significantly worse physical health compared to emotional/social well-being,which is associated with the presence of medical comorbidities.In terms of clinical outcomes,the incidence of appropriate shocks after GE among those with improvement in LVEF is very low,and most deaths post-procedure appear to be non-arrhythmic in origin.These data represent an attempt to more fully characterize the spectrum of QoL and clinical outcomes after GE. | Faisal M Merchant John Larson Leon Darghosian Paige Smith Soroosh Kiani Stacy Westerman Anand D.Shah David S.Hirsh Michael S.Lloyd Angel R.Leon Mikhael F.El-Chami | 2021 | Journal of Geriatric Cardiology2021，18，9： | 0 |
| 5 | A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection显示文摘There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor’s office to reduce the impact of serious disease.Many cancers are diagnosed late,leading to costly treatment and reduced life expectancy.With prostate cancer,the absence of a reliable test has inhibited the adoption of screening programs.We report a microelectronic point-of-care metabolite biomarker measurement platform and use it for prostate cancer detection.The platform,using an array of photodetectors configured to operate with targeted,multiplexed,colorimetric assays confined in monolithically integrated passive microfluidic channels,completes a combined assay of 4 metabolites in a drop of human plasma in under 2 min.A preliminary clinical study using L-amino acids,glutamate,choline,and sarcosine was used to train a cross-validated random forest algorithm.The system demonstrated sensitivity to prostate cancer of 94%with a specificity of 70%and an area under the curve of 0.78.The technology can implement many similar assay panels and hence has the potential to revolutionize low-cost,rapid,point-of-care testing. | Valerio F.Annese Samadhan B.Patil Chunxiao Hu Christos Giagkoulovits Mohammed A.Al-Rawhani James Grant Martin Macleod David J.Clayton Liam M.Heaney Ronan Daly Claudio Accarino Yash D.Shah Boon C.Cheah James Beeley Thomas R.Jeffry Evans Robert Jones Michael P.Barrett David R.S.Cumming | 2021 | Microsystems & Nanoengineering2021，7，2： | 0 |
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