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| 1 | New conjugate condi- tions and related nonlinear conjugategradient methods 显示文摘 | DAI YUHONG LIAO LIZHI | 2001 | Applied Mathematics and Optimization2001，43，： | 1 |
| 2 | New conjugacy conditions and related nonlinear conjugate gradient methods 显示文摘 | DAI Yuhong LIAO Lizhi | 2001 | Applied Mathematics and Optimization2001，43，： | 1 |
| 3 | New conjugacy conditions and related nonlinear conjugate gradient methods显示文摘 | DAI Yuhong LIAO Lizhi | | 0，，： | 1 |
| 4 | Characterization of 3D DNA Assemblies Using Cryogenic Electron Microscopy显示文摘DNA nanotechnology utilizes DNA double strands as building units for self-assembly of DNA nanostructures.The specific base-pairing interaction between DNA molecules is the basis of these assemblies.After decades of development,this technology has been able to construct complex and programmable structures.With the increase in delicate nature and complexity of the synthesized nanostructures,a characterization technology that can observe these structures in three dimensions has become necessary,and developing such a technology is considerably challenging.DNA assemblies have been studied using different characterization methods including atomic force microscopy(AFM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).However,the three-dimensional(3D)DNA assemblies always collapse locally due to the dehydration during the drying process.Cryogenic electron microscopy(cryo-EM)can overcome the challenge by maintaining three-dimensional morphologies of the cryogenic samples and reconstruct the 3D models from cryogenic samples accordingly by collecting thousands of two-dimensional(2D)projection images,which can restore their original morphologies in solution.Here,we have reviewed several typical cases of 3D DNA-assemblies and highlighted the applications of cryo-EM in characterization of these assemblies.By comparing with some other characterization methods,we have shown how cryo-EM promoted the development of structural characterization in the field of DNA nanotechnology. | WANG Mingyang DUAN Jialin DAI Lizhi XIN Xiaodong WANG Fangfang LI Zheng TIAN Ye | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 5 | Allelic reprogramming of chromatin states in human early embryos显示文摘The reprogramming of parental epigenomes in human early embryos remains elusive.To what extent the characteristics of parental epigenomes are conserved between humans and mice is currently unknown.Here,we mapped parental haploid epigenomes using human parthenogenetic and androgenetic embryos.Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse embryos.The allelic patterns of epigenetic states for orthologous regions are not conserved between humans and mice.Nevertheless,it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in humans and mice.In addition,for DNA-methylation-dependent imprinting,we report 19 novel imprinted genes and their associated germline differentially methylated regions.Unlike in mice,H3K27me3-dependent imprinting is not observed in human early embryos.Collectively,allele-specific epigenomic reprogramming is different in humans and mice. | Shenli Yuan Lei Gao Wenrong Tao Jianhong Zhan Gang Lu Jingye Zhang Chuanxin Zhang Lizhi Yi Zhenbo Liu Zhenzhen Hou Min Dai Han Zhao Zi-Jiang Chen Jiang Liu Keliang Wu | 2024 | National Science Review2024，11，3： | 0 |
| 6 | DNA-Based Architectures for in situ Target Biomolecule Analysis in Confined Nano-space显示文摘In situ target biomolecule analysis is of great significance for real-time monitoring and regulation of endogenous biomarkers and elementary biomolecules in vivo.Gratifyingly,the rapid evolution of structural DNA nanotechnology during past decades has established an appealing toolbox for biological analysis and medical detection.The modulated self-assembly and underlying canonical Watson-Crick base-pairing rules provide possibilities for accurate controlling of the topologies and functions of obtained nanomaterials.The probes composed of diverse DNA nanostructures and DNA-nanoparticle complexes can create a confined space,which increases target accessibility and improves probe stability,sensitivity and specificity.In this minireview,we retrospect the research progress of in-situ biomolecular analysis based on DNA nanostructures for intracellular and in vivo biosensors in confined space.The characteristics of distinct DNA nanomaterials are first introduced,and then the fundamentals of biosensing process of designed DNA nanostructures are emphasized.Moreover,we elucidate our perspective over the challenges of this field and discuss the potential directions of this kind of application-oriented fabrication technique. | Xiaoxue Hu Yide Huang Hao Yin Lizhi Dai Ye Tian | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
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