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| 1 | Chronic stress sensitizes rats to pancreatitis induced by cerulein:Role of TNF-α显示文摘AIM:To investigate chronic stress as a susceptibility factor for developing pancreatitis,as well as tumor necrosis factor-α (TNF-α) as a putative sensitizer.METHODS:Rat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) stimulation.Chronic restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed rats.RESULTS:In vitro exposure of pancreatic acini toTNF-α disorganized the actin cytoskeleton.This was further increased by TNF-α/CCK treatment,which additionally reduced amylase secretion,and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent manner.TNF-α/CCK also enhanced caspases' activity and lactate dehydrogenase release,induced ATP loss,and augmented the ADP/ATP ratio.In vivo,rats under chronic restraint exhibited elevated serum and pancreatic TNF-α levels.Serum,pancreatic,and lung inflammatory parameters,as well as caspases' activity in pancreatic and lung tissue,were substantially enhanced in stressed/cerulein-treated rats,which also experienced tissues' ATP loss and greater ADP/ATP ratios.Histological examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema,hemorrhage and leukocyte infiltrate,and pancreatic necrosis.Pancreatitis severity was greatly decreased by treating animals with an anti-TNF-αantibody,which diminished all inflammatory parameters,histopathological scores,and apoptotic/necrotic markers in stressed/cerulein-treated rats.CONCLUSION:In rats,chronic stress increases susceptibility for developing pancreatitis,which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation. | Marcelo G Binker Andres A Binker-Cosen Daniel Richards Herbert Y Gaisano Rodica H de Cosen Laura I Cosen-Binker | 2010 | World Journal of Gastroenterology2010，16，44： | 7 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 4 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 5 | Mammalian peptide transporters as targets for drug delivery显示文摘 | Rubio-Aliagu I Daniel H | 2002 | Trends in Pharmacological Sciences2002，23，9： | 1 |
| 6 | Subclinical thyroid disease: scientific review and guidelines for diagnosis and management 显示文摘 | SURKS M I ORTIZ E DANIELS G H | 2004 | JAMA2004，291，2： | 1 |
| 7 | Best practices selecting diffusers显示文摘 | Daniel I H | 2004 | ASHRAE J2004，，6： | 1 |
| 8 | Asymmetric Reduction of Ketones via Whole Cell Bioconversions and Transfer Hydrogenation:Complementary Approaches 显示文摘 | Annemarie H Danielle G I P Jim A | 2001 | Tetrahedron: Asymmetry2001，12，： | 1 |
| 9 | Subclinical thyroid disease: scientific review and guidelines for diagnosis and management显示文摘 | Surks M I Ortiz E Daniels G H | 2004 | JAMA2004，291，2： | 1 |
| 10 | Diagnostic lessons learnt from a series of enterovesical fistulae显示文摘 | Daniels I R Bekdash BC Scott H J | 2002 | Colorectal Disease2002，，： | 1 |
| 11 | Processing and characterization of epoxy/clay nanoeomposites显示文摘 | Daniel I M Miyagawa H Gdoutos E E | 2003 | Experimental Mechanics2003，43，3： | 1 |
| 12 | The shared landscape: what does aesthetics have to do with ecology? 显示文摘 | Gobster P H Nassauer J I Daniel T C | 2007 | Landscape Ecology2007，22，： | 1 |
| 13 | Processing and characterization of epoxy/clay nanocomposites显示文摘 | Daniel I M Miyagawa H Gdoutos E E | 2003 | Experimental Mechanics2003，43，3： | 1 |
| 14 | Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2 显示文摘 | Rubio-Aliaga I Boll M Daniel H | 2000 | Biochem Biophys Res Commun2000，276，2： | 1 |
| 15 | Subclinical thyroid disease:scientific review and guidelines for diagnosis and management显示文摘 | SURKS M I ORTIZ E DANIELS G H | 2004 | JAMA:the Journal of the American Medical Association2004，291，2： | 1 |
| 16 | Elastic properties of composites with fiber waviness显示文摘 | HSIAO H DANIEL I | 1996 | Composite Part A: Applied Science Manufacturing1996，27，10： | 1 |
| 17 | Nonlinear elastic behavior of unidi reetional composites with fiber waviness under compressive loading显示文摘 | HSIAO H DANIEL I | 1996 | Journal of Engineering Materials and Technolo- gy1996，118，4： | 1 |
| 18 | Effects of material and geometric nonlinearities on the tensile and compressive behavior of composite materials with fiber waviness显示文摘 | CHUN H J SHIN J Y DANIEL I M | 2001 | Corn-posite Science and Technology2001，61，1： | 1 |
| 19 | Malignant Pleural Effusions: Management options with consideration of coding, billing, and a dicision approach显示文摘 | Andrew R Daniel H Ali I | 2007 | Ghest2007，132，： | 1 |
| 20 | Subclinical thyroid disease:scientific review and guidelines for diagnosis and management显示文摘 | Surks M I Ortiz E Daniels G H | | 0，，： | 1 |
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