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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 4 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 5 | Processing of expanded graphite reinforced polymer nanocomposites显示文摘 | Yasmin A Luo J J Daniel I M | 2006 | Composites Sci- ence and Technology2006，66，： | 1 |
| 6 | Hydrodynamic effects on animal cells grown in microcarrier cultures显示文摘 | CROUGHAN M S HAMEL Jeen-Francois WANG DANIEL I C | 2000 | Biotechnology and Bioengineering2000，67，6： | 1 |
| 7 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 8 | Spectrum of KIT/ PDGFRA/BRAF mutations and l?hosphatidylinositol-3-Kinase pathway geue alterations in gastrointestinal stromal tumors (GIST) 显示文摘 | Daniels M Lurkin I Pauli R | 2011 | Cancer Lett2011，312，： | 1 |
| 9 | Effects of Microcarrier Concentration in Animal Cell Culture显示文摘 | CROUGHAN M S HAMEL Jeen-Francois WANG DANIEL I C | 1987 | Biotechnology and Bioengineering1987，32，8： | 1 |
| 10 | Automatic Control and Robotics显示文摘 | Gdoutos E E Daniel I M Schubel P | 2003 | Facta Universitatis Series:Mechanics2003，3，13： | 1 |
| 11 | Acous- tic Emission Monitoring of Fatigue Damage in Metals 显示文摘 | Daniel I M Luo J J Sifniotopoulos C G | 1998 | Nondestructive Testing and Evaluation1998，14，12： | 1 |
| 12 | Diagnosis and management of the metabolic syndrome an American heart association/ national heart, lung, and blood institute scientific statement 显示文摘 | GRUNDY S M CLEEMAN J I DANIELS S R | 2005 | Circulation2005，112，： | 1 |
| 13 | Mechanical and Thermal Proper- ties of Graphite Platelet/Epoxy Composites显示文摘 | Yasmin A Daniel I M | 2004 | Polymer2004，45，24： | 1 |
| 14 | Subclinical thyroid disease: scientific review and guidelines for diagnosis and management 显示文摘 | SURKS M I ORTIZ E DANIELS G H | 2004 | JAMA2004，291，2： | 1 |
| 15 | Mechanical enhancement of carbon fiber/epoxy composites by graphite nanoplatelet reinforcement显示文摘 | CHO J CHEN J Y DANIEL I M | 2007 | Scripta Materialia2007，56，8： | 1 |
| 16 | Operative treatment of intra - articular calcaneal fractures with calcaneal plates and its complications 显示文摘 | Vaclav R Daniel I Michal M | 2009 | Indian J Orthop2009，43，3： | 1 |
| 17 | Size effect and fracturecharacteristics of composite laminates 显示文摘 | BAZANT Z P DANIEL I M LI Z | 1996 | Journal of En-gineering Materials and Technology1996，118，3： | 1 |
| 18 | Subclinical thyroid disease: scientific review and guidelines for diagnosis and management显示文摘 | Surks M I Ortiz E Daniels G H | 2004 | JAMA2004，291，2： | 1 |
| 19 | Intracerebral event-related potentials to subthreshold target stimuli显示文摘 | Brazdil M Rektor I Daniel P | 2001 | Clin Neurophysiol2001，112，4： | 1 |
| 20 | Piezoelectric energy harvesting from a L-shaped beam-mass structure with an application to UAVs显示文摘 | Erturk A Jamil M R Daniel J I | 2009 | Journal of Intelligent Ma- terial Systems and Structures2009，20，： | 1 |
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