|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 3 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 4 | Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American heart association atherosclerosis, hypertension, and obesity in the young committee of the council on cardiovascular disease in the young; council on cardiovascular nursingl and council on nutrition, physical activity, and metabolism 显示文摘 | STEINBERGER J DANIELS S R ECKEL R H | 2009 | Circulation2009，119，： | 1 |
| 5 | Reich characterization of a quasi-one dimensional spin -1/2 magnet which is gapless and paramagnetic for gμBH≤J and kBT《J显示文摘 | Hammar P R Stone M B Daniel H | 1999 | Phys Rev B1999，59，2： | 1 |
| 6 | Relay-based deployment concepts for wireless and mobile broadband radio显示文摘 | PABST R BERNHARD W H DANIEL S C | 2004 | IEEE Communication Magazine2004，42，9： | 1 |
| 7 | Fuel Cell Cathode Air Filters: Methodologies for Design and Optimiza- tion 显示文摘 | Daniel M Kennedy Donald R Cahela Wenhua H Zhu | 2007 | Journal of Power Sources2007，168，1： | 1 |
| 8 | Catalytic combustion of methane on Co/MgO:characterisation of active cobalt sites显示文摘 | Ulla M A Spretz R Lombardo E Daniell W Knozinger H | | 0，，： | 1 |
| 9 | Containment of herbicide resistance through genetic engineering of the chloroplast genome显示文摘 | Daniell H Datta R Varma S Gray S.Lee S.B | | 0，，： | 1 |
| 10 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 11 | Are there better indices for evalu- ation purposes than the h index? A comparison of nine different variants of the h index using data from biomedicine 显示文摘 | Bornmann L Mutz R Daniel H D | 2008 | Journal of the Ameri- can Society for Information Science and Technology2008，59，5： | 1 |
| 12 | Matching demand and supply to maximize profits from remanufacturing显示文摘 | Daniel V Guide R Teunter R H | 2003 | Manufacturing & Service Operations Management2003，5，4： | 1 |
| 13 | Membrane selective exchange process for dilute methane recovery 显示文摘 | Lin H Daniels R Thompson S M | 2014 | J Membr Sci2014，469，： | 1 |
| 14 | 显示文摘 | Mai Q X Daniels R D Harpalani H B | 1988 | Thin Solid Films1988，166，： | 1 |
| 15 | Combustion and emissions of 2,5-dimethylfuran in a direct-injection spark-Ignition engine 显示文摘 | DANIEL R XU H M TURNER D | 2010 | Energy Fuels2010，24，5： | 1 |
| 16 | Quorum signal mol ecules as biosurfactants affecting swarming in Rhizobium etli 显示文摘 | Daniels R Reynaert S Hoekstra H | 2006 | PNAS2006，103，14： | 1 |
| 17 | Behavior and design of large openings in reinforced concrete beams 显示文摘 | Nasser K W Acavalos A Daniel H R | 1967 | ACI Journal1967，64，1： | 1 |
| 18 | Core-shell nanostructured nanoparticle films as chemically sensitive interfaces显示文摘 | Li H Daniel R D Maye M M | 2001 | Anal Chem2001，73，10： | 1 |
| 19 | The effect of CeO2 structure on the activity of supported pd catalysts used for methane steam reforming显示文摘 | Craciun R Daniell W Knozinger H | 2002 | Appl Catal A-Gen2002，230，12： | 1 |
| 20 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员