| 1 | Effect of particle size and oxygen content on ignition and combustion of aluminum particles显示文摘Particle size and oxygen content are two of the key factors that affect the ignition and combustion properties of aluminum particles. In this study, a laser ignition experimental system and flame test system were built to analyze the ignition and combustion characteristics and the flame morphology of aluminum particles. A thermobalance system was used to analyze the thermal oxidation characteristics. In addition, the microstructure of aluminum was analyzed by scanning electron microscopy. It was found that the oxidized products were some of the gas phase products agglomerated. Smaller particle size samples showed better combustion characteristics. The combustion intensity, self-sustaining combustion time and the burn-off rate showed a rising trend with the decrease in the particle size. Increasing the oxygen content in the atmosphere could improve the ignition and combustion characteristics of the samples. Four distinct stages were observed in the process of ignition and combustion. Small particle size samples had a larger flame height and luminance, and the self-sustaining combustion time was much longer.Three distinct stages were observed during the thermal oxidation process. The degree of oxidation for small-sized samples was significantly higher than that for the larger particle size samples.Moreover, it was observed that the higher the oxygen content, the higher the degree of oxidation was. | Yu'nan ZHOU Jianzhong LIU Daolun LIANG Wei SHI Weijuan YANG Junhu ZHOU | 2017 | Chinese Journal of Aeronautics2017，30，6： | 4 |
| 2 | Smad8 is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice显示文摘Background:SMAD family proteins(SMADs)are crucial transcription factors downstream of transforming growth factor beta(TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction.However,the role of SMAD family member 8(SMAD8,also known as SMAD9),a member of the SMAD family,in mammalian reproduction remains unclear.Methods:We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells(GCs)to investigate the effects of Smad8 on GC growth and steroidogenesis.Results:Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate of GCs after transfection with Smad8-siRNA for 48 h.Subsequent hormone assays demonstrated a significant decrease in estradiol(E2)levels,whereas progesterone(P4)remained unchanged.Further mechanistic analysis showed that the mRNA expression of proliferating cell nuclear antigen(Pcna),Cyclin D2,cell cycle-dependent kinase 4(Cdk4),B-cell lymphoma-2(Bcl-2),estrogen receptor(Er),luteinizing hormone receptor(Lhr)and cytochrome P450 family 19 subfamily A member 1(Cyp19a1)significantly decreased.Conversely,the mRNA of cysteine aspartate proteinase 3(Caspase 3)significantly increased,wheras Bcl2-associated X(Bax),folliclestimulating hormone receptor(Fshr)and cytochrome P450 family 11 subfamily A member 1(Cyp11a1)remained unchanged compared to the controls.Conclusion:This study indicates that Smad8 knockdown inhibits cell proliferation,promotes apoptosis,reduces Er and Lhr transcription,and decreases E2 production in mouse GCs.These findings suggest that Smad8 may serve as a novel genetic marker for mammalian reproduction. | DAOLUN YU DEYONG SHE KAI GE LEI YANG RUINA ZHAN SHAN LU YAFEI CAI | 2024 | BIOCELL2024，48，1： | 0 |
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