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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Optimal sensor distribution for variation diagnosis in multistation assembly processes 显示文摘 | Yu D Pansoo K Dariusz C | 2003 | IEEE Transactions on Robotics and Automation2003，19，4： | 1 |
| 3 | Multilevel selective harmonic elimination PWM technique in series-connected voltage inverters 显示文摘 | LI L DARIUSZ C LIU Y G | 2000 | Transactions on Industry Applications2000，36，1： | 1 |
| 4 | Numerical modelling and thermal simulation of PCM - gypsum composites with ESP - r 显示文摘 | DARIUSZ H JOE A C | 2004 | Energy and Buildings2004，36，8： | 1 |
| 5 | Process capability surrogate model - based tolerance systhesis for multi - station manufacturing system 显示文摘 | Huang W Z Tirawat P Dariusz C | 2009 | IIE Transaction2009，，41： | 1 |
| 6 | Estimation of repairable system availability within fixed time horizon 显示文摘 | HENRYK M DARIUSZ C | 2008 | Reliability Engineering and System Safety2008，3，： | 1 |
| 7 | Estimation of repairable system availability within fixed time horizon显示文摘 | HENRYK M DARIUSZ C | 2008 | Reliability Engineering and System Safety2008，93，： | 1 |
| 8 | Numerical modelling and thermal simulation of PCM-gypsum composites with ESP-r显示文摘 | Dariusz H Joe A C | 2004 | Energy and Buildings2004，36，8： | 1 |
| 9 | Standardization protocols and optimized precursor sets for the efficient application of automated parallel synthesis to lead optimization : a mitsunobu example 显示文摘 | Gentles Robert G Wodka Dariusz Park David C | 2002 | Journal of Combinatorial Chemistry2002，4，5： | 1 |
| 10 | Applicability of Gd-doped BaZrO 3 , SrZrO 3 , BaCeO 3 and SrCeO 3 proton conducting perovskites as electrolytes for solid oxide fuel cells显示文摘 | Wojciech Zaj?c Dariusz Rusinek Kun Zheng Janina Molenda | 2013 | Central European Journal of Chemistry2013，，4： | 1 |
| 11 | Listing BRICs:Stock Issuers from Chi- na,Brazil, Russia and India in New York, London and Luxem- bourg显示文摘 | Dariusz W - C Burger | 2010 | Economic Geography2010，，： | 1 |
| 12 | Incidence and risk factors for central venous catheter -related thrombosis in hematological patients显示文摘 | MONIKAN J ANNA C DARIUSZ P | 2014 | Med Oncol2014，31，1： | 1 |
| 13 | An improved MTT assay显示文摘 | DARIUSZ S Saran J S Richard H C | | 0，，： | 1 |
| 14 | Groundwater hydrochemistry and soil pollution in a catchment affected by an abandoned lead-zinc mine: functioning of a diffuse pollution source显示文摘 | URSZULA A K DARIUSZ C | 2012 | Environmental Earth Sciences2012，65，4： | 1 |
| 15 | Comparative analysis of tooth-root strength using ISO and AGMA standards in spur and helical gears with FEM-based verification显示文摘 | Andr'zej K Jerzy W Dariusz C | 2006 | ASME Journal of Mechanical Design2006，128，： | 1 |
| 16 | Geometric aspects of quantum mechanics and quantum entanglement显示文摘 | DARIUSZ C | 2006 | J Phys: Conf Ser2006，30，： | 1 |
| 17 | Identification and synthesis of some contaminants present in 4-methoxyamphetamine(PMA)prepared by the Leuckart method显示文摘 | Krystyna W Zbigniew C | 2002 | Forensic Science International2002，127，： | 1 |
| 18 | Hydraulic controls on the entrapment of heavy metal-polluted sediments on a floodplain of variable width, the upper Vistula River, southern Poland显示文摘 | Barfiomiej W Dariusz C | 2010 | Geomorphology2010，117，： | 1 |
| 19 | The nuclear factor-kappaB (NF-KB) : from a versatile transcription factor to a ubiquitous therapeutic target 显示文摘 | Laura L Dariusz C | 2006 | Acta Biochim Polonica2006，53，4： | 1 |
| 20 | Estimation of repairable system availa- bility within fixed time horizon显示文摘 | Henryk M Dariusz C | 2008 | Reliability Engineering and System Safety2008，93，1： | 1 |
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