|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 4 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 5 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 6 | Analysis of air gap flux current and vibration signals as a function of the combination of static and dynamic air-gap eccentricity in 3-phase induction motors显示文摘 | David G Dorrell William T Thomson Steven Roach | 1997 | IEEE Transactions on Industry Applications1997，33，1： | 1 |
| 7 | Relations among sprinkler uniforrnity measures显示文摘 | Beale J G David T H | 1966 | Journal of Irrigation and Drainage Division1966，92，1： | 1 |
| 8 | Results of disc prosthesis after a minimum follow-up period of 2 years显示文摘 | David T Postacchini F | 1996 | Spine1996，21，8： | 1 |
| 9 | ABC of psychological medicine: abdominal pain and functional gastrointestinal disorders显示文摘 | ELSPETH G DAVID T | 2002 | BMJ2002，325，7366： | 1 |
| 10 | The effects of system and geometric parameters on abrasive water jet nozzle wear显示文摘 | MADHUSARATHI N DAVID G T THOMAS J K | 2002 | International Jour- nal of Machine Tools b- Manufacture2002，42，： | 1 |
| 11 | Enhancement of metal dispersion and selective acetylene hydrogenation catalytic properties of a supported Pd catalyst 显示文摘 | Feng J T Ma X Y David G E | 2011 | Industrial Engineering Chemical Research2011，50，4： | 1 |
| 12 | Carcinogenic Assessments of Petroleum Product by Neelear Magnetic Resonance显示文摘 | David T Coker Alexander G King Dirk I Mumford el al | 1997 | Analytical Communications1997，34，5： | 1 |
| 13 | Probability of successful defibrillation at multiples of the defibrillation energy requirernent in patients with an implantable defibrillator显示文摘 | Strickberger S A Daoud E G David son T | | 0，，： | 1 |
| 14 | Use of standardize dpatients otassess between-physician variations in resource utilization显示文摘 | Peter J M Robyn M T David G etal | 1997 | JAMA1997，278，： | 1 |
| 15 | Electron spin resonance detection of spin - trapped radicals formed during the glow- discharge electrolysis of aqueous solutions 显示文摘 | ANTHONY T DAVID L G MALCOLM D I | 1980 | J C S Faraday I1980，76，： | 1 |
| 16 | Serum homocysteine andlong term risk of myocardial infarction and sudden death inpatients with coronary heart disease显示文摘 | Moti H David T Uri G | | 0，，： | 1 |
| 17 | Long - term re- sults of aortic valve - sparing operations for aortic root aneurysm 显示文摘 | DAVID T E FEINDEL C M WEBB G D | 2006 | J Thorac Cardiovasc Surg2006，132，2： | 1 |
| 18 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 19 | Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors:A randomized,Phase Ⅲ double-blind,placebo-controlled trial显示文摘 | Rosen LS David G Simon T | 2004 | Cancer2004，100，12： | 1 |
| 20 | Heparan sulphate proteoglycan expression in human primary liver tumours 显示文摘 | ROSKAMS T DE VOS R D DAVID G | 1998 | J Pathol1998，185，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员