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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 3 | Acute coronary syndrome: a rare case of multiple endocrine neoplasia syndromes with pheochromocytoma and medullary thyroid carcinoma显示文摘Pheochromocytoma is a tumor arising from neuroectodermal chromaffin tissues in the adrenal gland or extra-adrenal paraganglia(paragangliomas). The prevalence of the tumor is 0.1%-0.6% in the hypertensive population, of which 10%-20% are malignant. Pheochromocytoma produces, stores, and secretes catecholamines, as well as leads to hypertensive crisis, arrhythmia, angina, and acute myocardial infarction without coronary artery diseases. We report a case of acute coronary syndrome(ACS) with a final diagnosis of multiple endocrine neoplasia with pheochromocytoma and medullary thyroid carcinoma(MTC). | Alessadro Maloberti Paolo Meani Roberto Pirola Marisa Varrenti Marco Boniardi Anna Maria De Biase Paola Vallerio Edgardo Bonacina Giuseppe Mancia Paola Loli Cristina Giannattasio | 2015 | Cancer Biology & Medicine2015，12，3： | 4 |
| 4 | Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass显示文摘 | Speranza Rubattu Sebastiano Sciarretta Giuseppino Massimo Ciavarella Vanessa Venturelli Paola De Paolis Giuliano Tocci Luciano De Biase Andrea Ferrucci Massimo Volpe | 2007 | Journal of Hypertension2007，，4： | 2 |
| 5 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 6 | Stability and oligomerization of recombinant GadX, a transcriptional activator of the Escherichia coli glutamate decarboxylase system显示文摘 | TRAMONTI A DE CANIO M DE BIASED | 2003 | Biochim Biophysic Aeta2003，1647，： | 1 |
| 7 | Estimation of soil water repellency of different particle size fractions in relation with carbon content by different methods 显示文摘 | Rodriguez-Alleres M de Bias E Benito E | 2007 | Science of the Total Environment2007，378，12： | 1 |
| 8 | Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells ( HL60, NB4 ) Protein kinase modulation and reactive oxygen species generation 显示文摘 | Sanehez Y Amran D de Bias E | 2009 | Bioehem Pharmacol2009，77，3： | 1 |
| 9 | Sorption of heavy metals from industrial wastewater by low cost mineral silicates 显示文摘 | Sanchez A G Ayuso E A De Bias O J | 1999 | Clay Minerals1999，34，3： | 1 |
| 10 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 11 | Excitability and synaptic communication within the oligodendrocyte lineage显示文摘 | De Biase LM Nishiyama A Bergles DE | | 0，，10： | 1 |
| 12 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 13 | A program to protocolize nursing care 显示文摘 | Olmedo Luceren MC Sanchidrien de Bias C P16 Mestre R | 2010 | Rev Cali- dAsist2010，25，5： | 1 |
| 14 | Performance response of lactating and growing rabbits to dietary threonine content 显示文摘 | Bias C DE Taboada E Nicodemus N | 1998 | Animal Feed Science and Technology1998，70，12： | 1 |
| 15 | Scaffolds combin- ed with stem cells and growth factors in healing ofpseudotumoral lesions of bone显示文摘 | De Biase P Campanacci DA Beltrami G | 2011 | Int J Immunopathol Pharmacol2011，24，12： | 1 |
| 16 | Estimation of soil water repellency of different particle size frae- tions in relation with carbon content by different meth- ods显示文摘 | Rodr guez-Alleres M De Bias E Benitoe | 2007 | Science of Total Environment2007，378，： | 1 |
| 17 | LM6000 sprint design enhanced to increase power and efficiency 显示文摘 | BIAS DE V | 2000 | Gas Turbine worl d2000，，4： | 1 |
| 18 | In vitro com- petitive adhesion and production of antagonistic com- pounds by lactic acid bacteria against fish pathogens 显示文摘 | Balcazar J L Vendrell D de Bias I | 2007 | Veterinary Microbiology2007，122，34： | 1 |
| 19 | Distallybased superficial sural flap:advantages of the adipofascial over the fasciocutaneous flap显示文摘 | Parodi PC de Bias io F Rampino-Cordaro E | 2010 | Scand J Plast Reconstr Surg Hand Surg2010，44，1： | 1 |
| 20 | Structure and evolution of the mitochondrial control region of the pollen beetle Meligethes thalassophilus (Coleoptera:Nitidulidae)显示文摘 | Mancini E De Biase A Mariottini P Bellini A Audisio P | | 0，，03： | 1 |
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