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14篇 您的检索式：作者名="DE GEEST H"

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		题名	作者	年代	出处	被引量
	1	Falls and consequent injuries in hospitalized patients: Effects of an interdisciplinary falls prevention program显示文摘	Schwendimann R Buhler H De Geest S el al	2006	BMC Health Serv Res2006，6，：	1
	2	Angiographic assessment of the infarct - related residua coronary stenosis after spontaneous or therapeutic thrombolysis显示文摘	LIERDE J V DE GEEST H VERSTRAETE M	1990	JAOC1990，16，7：	1
	3	Variations in blood flow waveforms in stenotic renal arteries by 2D phase- contrast cine MRI显示文摘	Westenberg J J Wasser M N van der Geest R J Pattynama P M de Roos A Vanderschoot J Reiber J H C	1998	JMagn Reson Imag1998，8，3：	1
	4	Characteristics of hospital inpatient falls across clinical departments显示文摘	Schwendimann R Buhler H De Geest S		0，，06：	1
	5	Falls and consequents injuries in hospitalized patients:Effects of an interdisciplinary falls prevention program显示文摘	Sehwendimann R Buhler H De Geest S el al	2006	BMC Health Serv Res2006，6，：	1
	6	ASH posi-tion paper: adherence and persistence with takingmedication to control high blood pressure显示文摘	Hill M N Miller N H De Geest S	2010	J ClinHypertens ( Greenwich )2010，12，10：	1
	7	Torsades de pointes after intracoronary pa- paverine显示文摘	Yrolix M Piessens J de Geest H	1991	Eur Heart J1991，12，：	1
	8	Falls and consequent injuries in hospitalized patients: effects of an interdisciplinary falls prevention program显示文摘	Schwendimann R Biihler H De Geest S	2006	BMC Health Serv Res2006，6，：	1
	9	The underlying heart rhythm in patients with an artificial cardiac pacemaker显示文摘	STAESSEN J ECTOR H DE GEEST H	1982	PACE1982，5，：	1
	10	Minimally invasive video-assisted mitral valve repair short and mid-term results 显示文摘	Wellens F De Geest R Degrieck I Van Praet F Vermealer Y Vaner Men H	2001	J Heart Valve Dis2001，10，5：	1
	11	Repair of de- scending thoracic aneurysms through a left posterolater- al thoracotomy using deep hypothermic circulatory ar- rest显示文摘	DOSSCHE K DEFERM H de GEEST R	1996	Eur J Cardiothorac Surg1996，10，9：	1
	12	Characteristics of hospital inpatient falls across clinical departments显示文摘	Chwendimann R Blihler H De Geest S	2008	Gerontology2008，54，：	1
	13	Right ventric- nlar function in patients with acute pulmonary embolism: analysis with electrocar- diography-synchronized muhi-detector row CT显示文摘	Dogan H Kroft LJ Huisman MV van der Geest RJ de Roos A	2007	Radlology2007，242，：	1
	14	Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells显示文摘Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft substitutes.Polymethylmethacrylate(PMMA)cement is the most commonly used bone substitute in clinical orthopedics in view of its reliability.However,the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone tumors.Here,we introduce porosity into PMMA cement by adding carboxymethylcellulose(CMC)to facilitate such local delivery of chemotherapeutic drugs,while retaining sufficient mechanical properties for bone reconstruction in load-bearing sites.Our results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC content.Upon incorporation of≥3%CMC,the PMMA-based cements released up to 18%of the loaded cisplatin,in contrast to cements containing lower amounts of CMC which only released less than 2%of the cisplatin over 28 days.This release of cisplatin efficiently killed osteosarcoma cells in vitro and the fraction of dead cells increased to 91.3%at day 7,which confirms the retained chemotherapeutic activity of released cisplatin from these PMMA-based cements.Additionally,tibias filled with PMMA-based cements containing up to 3%of CMC exhibit comparable compressive strengths as compared to intact tibias.In conclusion,we demonstrate that PMMA cements can be rendered therapeutically active by introducing porosity using CMC to allow for release of cisplatin without compromising mechanical properties beyond critical levels.As such,these data suggest that our dual-functional PMMA-based cements represent a viable treatment option for filling bone defects after bone tumor resection in load-bearing sites.	Zhule Wang Liebert Parreiras Nogueira Håvard Jostein Haugen Ingrid CM.Van Der Geest Patricia Caetano de Almeida Rodrigues Dennis Janssen Thom Bitter Jeroen J.J.P.van den Beucken Sander CG.Leeuwenburgh	2022	Bioactive Materials2022，7，9：	1

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