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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 3 | Cloning of first abc transporter encoding gene from Trichoderma spp. and its expression during stress and mycoparasitism显示文摘Trichoderma in its natural environment competes for nutrient uptake and is required to protect itself from adverse natural toxic compounds, such as those produced by plants and other microbes in the soil community, or synthetic toxic compounds released human activity. One of the most important metabolic pathways for drug resistance and substrate uptake, both in prokaryotes and eukaryotes, is ATP dependent. The role of ABC transporter proteins in the biology of Trichoderma is still not known. We present the cloning of the first four ABC transporter genes (TABC1, TABC2, TABC3, TABC4 ) in Trichoderma, and in particular T. atroviride P1, and the characterization of TABC2 The complete sequence of this gene is 6535 bp, which includes a promoter of 1624 bp, a terminator of 642 bp and a coding region of 4264 bp. The promoter contains many of the potential transcription factor binding sites found in the 5’ upstream region of the ech42 gene of T. atroviride P1. These included: heat shock factors (HSF), a nitrogen-regulating factor (Nit-2), a stress-response element (STRE), a GCR1 elements, and a Cre BP1 motif. Northern analysis and RT-PCR demonstrated that TABC2 is highly expressed when Trichoderma is subjected to nitrogen starvation, grown in the presence of culture filtrates of Botrytis cinerea, Rhizoctonia solani, and Pythium ultimum, or when N-acetylglucosamine is added to the substrate. TABC2 appears to be co-regulated with some CWDE-encoding genes, suggesting that this is the first ABC transporter encoding gene involved in mycoparasitic events. It’s role in the interaction of Trichoderma with fungal hosts or plants is being investigated by targeted gene disruption and overexpression. | Lanzuise S Ruocco M Scala V Catapano L Woo S Ciliento R Ferraioli S Soriente I Vinale F Scala F Del Sorbo G Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 4 | Effects of thermal and mechanical pretreatments of secondary sludge on biogas production under thermophilic conditions显示文摘 | Mavi Climent Ivet Ferrer Ma del Mar Baeza Adriana Artola Felícitas Vázquez Xavier Font | 2007 | Chemical Engineering Journal2007，，1： | 2 |
| 5 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 6 | The effects of brand associations on consumer response显示文摘 | A. Belén del Río Rodolfo Vázquez Víctor Iglesias | 2001 | Journal of Consumer Marketing2001，，5： | 2 |
| 7 | Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis:requirement for Akt activation显示文摘 | Del Bufalo D Di Castro V Biroccio A | 2002 | Mol Pharmacol2002，61，： | 1 |
| 8 | Electrochemical and spectroscopic studies of ethanol oxidation on Pt stepped surfaces modified by tin adatoms 显示文摘 | Del Colle V Souza-Garcia J Tremiliosi G | 2011 | Physical Chemistry Chemical Physics2011，13，12： | 1 |
| 9 | Mechanical properties of polyester mooring cables 显示文摘 | FERNANDES A C DEL VECCI-IIO C J M CASTRO G A V | 1999 | International Journal of Offshoreand Polar Engineering1999，9，3： | 1 |
| 10 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 11 | HACCP planproposal for a typical Brazilian peanut processing company 显示文摘 | Gorayeb T C C Casciatori F P Del Bianchi V L | 2009 | Foodcontrol2009，，20： | 1 |
| 12 | Galactomannan testing might be useful for early diagnosis of fusariosis显示文摘 | Mikulska M Furfaro E Del Bono V | 2012 | Diagn Micro- biol Infect Dis2012，72，4： | 1 |
| 13 | Progressive lacunar stroke : Re- view of mechanisms, prognostic features, and putative treatments显示文摘 | Del Bene A Palumbo V Lamassa M | 2012 | Int JStroke2012，7，4： | 1 |
| 14 | Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis 显示文摘 | Del Bo R Tiloca C Pensato V | 2011 | J Neurol Neurosurg Psychiatry2011，82，11： | 1 |
| 15 | Lipoxicity in human pancreatic islets and the protective effect of metformin 显示文摘 | Lupi R Del Guema S Fiembracci V | 2002 | Diabetes2002，51，1： | 1 |
| 16 | Endogenous reductants support the catalytic function of recombinant rat cyt19,an arsenic methyltransferase显示文摘 | Waters SB Devesa V Del Razo LM | 2004 | Chem Res Toxicol2004，17，3： | 1 |
| 17 | Organic matter removal in combined anaerobic-aerobic fixed-film bioreactors显示文摘 | Del Pozo R Diez V | 2003 | Water Research2003，37，： | 1 |
| 18 | Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 显示文摘 | Del Gaizo Moore V Brown JR Certo M | 2007 | J Clin Invest2007，117，1： | 1 |
| 19 | A com- bination of antigenic regions of Toxoplasma gondii microneme proteins induces protective immunity against oral infection with parasite cysts 显示文摘 | BEGHETTO E NIELSEN H V DEL PORTO P | 2005 | J Infect Dis2005，191，4： | 1 |
| 20 | Concomitant and feasible treatment with dasatinib and the anti-EGFR antibody cetuximab plus radiotherapy in a CML patient with multiple squamous neoplasias显示文摘 | Stagno F Vigneri P Del Fabro V | 2010 | Acta Oncol2010，49，1： | 1 |
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