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| 1 | Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity显示文摘在 mevalonate 小径的 multigenic 家庭的存在为涉及植物甾醇的生合成的小径部件建议分叉的功能的角色。Squalene epoxidases (SQE ) 是这条小径的关键部件,并且 Squalene Epoxidase 1 (SQE1 ) 在这 biosynthetic 步作为基本的酶被识别了。在现在的工作,我们扩大了留下的 SQE 家庭成员的描述,种系发生地在真 SQE 和对 Brassicaceae 独占的象 SQE 一样蛋白质的一个亚科之间解决。真 SQE 家庭成员, Squalene Epoxidase 2 (SQE2 ) 和 Squalene Epoxidase 3 (SQE3 ) 的功能的描述,显示那 SQE3,然而并非 SQE2,在 Arabidopsis 贡献体积 SQE 活动,与积累 squalene 并且显示敏感到 terbinafine 的 sqe3-1 异种。我们遗传上证明 SQE3 似乎在胚胎开发起一个特别地重要的作用。另外, SQE1 和 SQE3 两个都在 endoplasmic 蜂窝胃本地化,并且 SQE3 能机能上地补充 SQE1。因此, SQE1 和 SQE3 似乎是在在 Arabidopsis 的工厂 SQE 活动的提升的二机能上地不相等的冗余的基因。 | Sara Laranjeira Vitor Amorim-Silva Alicia Esteban Monserrat Arro Albert Ferrer Rui Manuel Tavares Miguel Angel Botella Abel Rosado Herlander Azevedo | 2015 | Molecular Plant2015，8，7： | 12 |
| 2 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 3 | 液相飞行时间质谱(LC/MSD TOF)和液相色谱/离子阱质谱(LC/MSD Trap)测定色拉蔬菜中的氯烟碱类杀虫剂显示文摘本工作考察了液相色谱/飞行时间质谱检测器(LC/MSDTOF)和液相/离子阱质谱检测器(LC/MSDTrap)联用技术分析一些氯烟碱类杀虫剂的可行性.杀虫剂包括:啶虫咪(acetamiprid),吡虫啉(imidacloprid)和噻虫啉(thiacloprid).色拉蔬菜有四种:番茄、辣椒、莴苣和黄瓜.本文介绍的内容包括三种氯烟碱类杀虫剂的LC/MSDTOF和LC/MSDTrap质谱,TOF获得的实验分子式和四种蔬菜基质中氯烟碱类杀虫剂的MS/MS碎片离子.同时也将详细介绍样品制备程序以及色拉蔬菜中杀虫剂的回收、最低检测限(MDL)的质谱质量、线性,使用TOF和Trap对纯溶剂和四种蔬菜提取物中杀虫剂的定量分析.给出了来自市场的实际色拉蔬菜样品中杀虫剂的分析结果. | Imma Ferrer EMichael Thurman Jerry Zweigenbaum | 2005 | 环境化学2005，24，3： | 8 |
| 4 | 验证美国感染病学会与美国胸科学会社区获得性肺炎指南对预测需入住ICU患者的临床意义显示文摘 | Liapikou A Ferrer M Polverino E 李颖 杨帆 | 2010 | 中国感染与化疗杂志2010，10，5： | 7 |
| 5 | A transition prediction method for flow over airfoils based on high-order dynamic mode decomposition显示文摘This article presents a novel approach for predicting transition locations over airfoils,which are used to activate turbulence model in a Reynolds-averaged Navier-Stokes flow solver.This approach combines Dynamic Mode Decomposition(DMD)with e^Ncriterion.The core idea is to use a spatial DMD analysis to extract the modes of unstable perturbations from a steady flowfield and substitute the local Linear Stability Theory(LST)analysis to quantify the spatial growth of Tollmien–Schlichting(TS)waves.Transition is assumed to take place at the stream-wise location where the most amplified mode’s N-factor reaches a prescribed threshold and a turbulence model is activated thereafter.To improve robustness,the high-order version of DMD technique(known as HODMD)is employed.A theoretical derivation is conducted to interpret how a spatial highorder DMD analysis can extract the growth rate of the unsteady perturbations.The new method is validated by transition predictions of flows over a low-speed Natural-Laminar-Flow(NLF)airfoil NLF0416 at various angles of attack and a transonic NLF airfoil NPU-LSC-72613.The transition locations predicted by our HODMD/e^Nmethod agree well with experimental data and compare favorably to those obtained by some existing methods■.It is shown that the proposed method is able to predict transition locations for flows over different types of airfoils and offers the potential for application to 3D wings as well as more complex configurations. | Mengmeng WU Zhonghua HAN Han NIE Wenping SONG Soledad Le CLAINCHE Esteban FERRER | 2019 | Chinese Journal of Aeronautics2019，32，11： | 7 |
| 6 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 7 | Reduction of NO by CO using Pd–CeTb and Pd–CeZr catalysts supported on SiO_2 and La_2O_3–Al_2O_3显示文摘The catalytic activity of Pd catalysts supported on Ce0.73Tb0.27 O x/Si O2, Ce0.6Zr0.4O x/Si O2,Ce0.73Tb0.27 O x/La2O3–Al2O3and Ce0.6Zr0.4O x/La2O3–Al2O3was studied using the reduction of NO by CO. The catalysts were characterized by X-ray fluorescence, surface area, X-ray diffraction, temperature-programmed reduction, CO chemisorption and oxygen storage capacity. Temperature-programmed reduction results indicated that Tb or Zr incorporation improves the reducibility and oxygen storage capacity. CO chemisorption data suggested the presence of large Pd O particles due to the low CO/Pd ratio. No significant differences were obtained in light off temperatures(T Light off) for all Pd catalysts and the most active was1.5%Pd/Ce0.6Zr0.4O x/Si O2. | Victor Ferrer Dora Finol Roger Solano Alexander Moronta Miguel Ramos | 2015 | Journal of Environmental Sciences2015，27，1： | 7 |
| 8 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 9 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 10 | 液相色谱/离子阱质谱和飞行时间质谱分析橄榄油中的特丁津除草剂显示文摘本文摘要介绍了液相色谱/离子阱质谱和液相/飞行时间质谱对橄榄油中特丁津的定性定量分析.详细介绍了样品处理,包括液液萃取和以氨基硅胶为基质分散的固相萃取法.样品的净化采用Florisil硅土小柱,用乙腈洗脱溶质.液相色谱/离子阱质谱的MS/MS模式采集特征离子m/z174.而利用液相/飞行时间质谱进行精确质量数分析(\[M+H\]+,m/z230),同时得到碎片的精确质量数和特征同位素分布.对于飞行时间质谱测得的质量精度小于ppm.此方法具有高灵敏度、线性好及精度高的优点.液相/离子阱质谱和飞行时间质谱可以作为橄榄油中特丁津的常规方法. | Imma Ferrer Michael Thurman Jerry Zweigenbaum | 2005 | 环境化学2005，24，6： | 5 |
| 11 | PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) Integrates the Regulation of Sugar Responses with Isoprenoid Metabolism in Arabidopsis显示文摘在植物房间的 isoprenoids 的生合成从 mevalonate (MVA ) 在 cytosol 生产的先锋发生小径并且在由 methylerythritol 4 磷酸盐(MEP ) 的质体,小径,而是很少对协调两条小径的机制被知道。在 Arabidopsis thaliana 为如此的协作发信号的糖的重要性的证据被没有变化,在相关 MEP 小径抄本,蛋白质,或酶活动的层次显示出导出 MEP 的 isoprenoid 产品(叶绿素和类胡萝卜素) 的增加的累积的异种的描述这里提供。这异种被发现是新 loss-of-function 等位基因 PRL1 (多种的规章的地点 1 ) ,编码作为糖的一个全球管理者工作的保存 WD 蛋白质的基因,应力,和荷尔蒙回答,部分地由 SNF1 相关的蛋白质 kinases (SnRK1 ) 的抑制。与在 MVA 小径的主要的规章的酶的 phosphorylation 和 inactivation 的 SnRK1 kinases 的报导角色一致(hydroxymethylglutaryl 辅酶 -- reductase ) ,它的活动或蛋白质层次在 prl1 幼苗被减少。然而,导出 MVA 的结束产品(甾醇) 的累积在变异的幼苗是未改变的。蔗糖补充到野类型的幼苗 phenocopied prl1 变化以 isoprenoid 新陈代谢,建议观察 isoprenoid 显型从增加的糖累积导致 prl1 异种。在摘要, PRL1 看起来与糖,荷尔蒙,和压力回答协调 isoprenoid 新陈代谢。 | Ursula Flores-Perez Jordi Perez-Gil Marta Closa Louwrance R Wright Patricia Botella-Pavia Michael A. Phillips Albert Ferrer Jonathan Gershenzon Manuel Rodriguez-Concepcion | 2010 | Molecular Plant2010，3，1： | 5 |
| 12 | Pretreatment methods to improve sludge anaerobic degradability: A review显示文摘 | H. Carrère C. Dumas A. Battimelli D.J. Batstone J.P. Delgenès J.P. Steyer I. Ferrer | 2010 | Journal of Hazardous Materials2010，，1： | 5 |
| 13 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 14 | Drag reduction via turbulent boundary layer flow control显示文摘Turbulent boundary layer control(TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational-simulation capabilities,which have improved the understanding of the flow structures of turbulence.Advances in micro-electronic technology have enabled the fabrication of active device systems able to manipulating these structures.The combination of simulation,understanding and micro-actuation technologies offers new opportunities to significantly decrease drag,and by doing so,to increase fuel efficiency of future aircraft.The literature review that follows shows that the application of active control turbulent skin-friction drag reduction is considered of prime importance by industry,even though it is still at a low technology readiness level(TRL).This review presents the state of the art of different technologies oriented to the active and passive control for turbulent skin-friction drag reduction and contributes to the improvement of these technologies. | ABBAS Adel BUGEDA Gabriel FERRER Esteban FU Song PERIAUX Jacques PONS-PRATS Jordi VALERO Eusebio ZHENG Yao | 2017 | Science China(Technological Sciences)2017，60，9： | 4 |
| 15 | Strain-induced band gap engineering in layered TiS3显示文摘 | Robert Biele Eduardo Flores Jose Ramon Ares Carlos Sanchez Isabel J. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta | 2018 | Nano Research2018，11，1： | 3 |
| 16 | 有无正当理由违约中的损害赔偿——从案例分析的角度显示文摘通过对国际体育仲裁违约合同造成损害赔偿的案例分析,提出没有固定的规则可以适用所有的案例,唯一确定的是所谓的'积极利益'或'预期利益'原则。因此,裁定方确定赔偿金是以假设违约未发生,受害方应当获得利益大小为标准。任何人都不应当试图创设一个固定规则,因为尝试创设规则是不明智的,它将导致裁定方因固定规则被迫以某种方式裁定,并不能实现双方当事人及体育领域所追求的公正、合理的结果。文章认为由裁定方在考虑到所有情形的前提以积极利益原则为首要原则确定最合适的赔偿金。 | Lucas Ferrer 杨蓓蕾 | 2012 | 体育科研2012，33，6： | 2 |
| 17 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 18 | LC/TOF MS分子特征数据库检索方法进行食品中600种农药的自动筛选显示文摘通过液相色谱/飞行时间质谱在正离子模式下全扫描精确质谱测定,建立了分子特征(MF)算法进行数据库检索的方法用于筛选食品提取物中600种农药及其降解产物。数据库检索将实际化合物检测和鉴定中得到的离子的精确质量数收集起来,并且将它们与数据库中化合物的单一同位素的准确质量数进行比较。筛选标准包括:±5 ppm精确质量窗口;±0.2分钟保留时间窗口;最小峰面积计数1000(信噪比约为10:1)。检出限和保留时间是由600种化合物中的100种来确定,其中34%的化合物的检出限小于0.01mg/kg,95%的化合物的检出限小于0.5 mg/kg。与需要几小时到几天的手工方法相比,分子特征算法的优势在于它可以在几分钟内灵敏快速地筛选几百种化合物。 | E.Michael Thurman Imma Ferrer Jerry A.Zweigenbaum | 2010 | 食品安全质量检测学报2010，1，3： | 2 |
| 19 | The impact of remanufacturing in the economy显示文摘 | Geraldo Ferrer Robert U Ayres | 2000 | Ecological Economics2000，32，： | 2 |
| 20 | Effects of thermal and mechanical pretreatments of secondary sludge on biogas production under thermophilic conditions显示文摘 | Mavi Climent Ivet Ferrer Ma del Mar Baeza Adriana Artola Felícitas Vázquez Xavier Font | 2007 | Chemical Engineering Journal2007，，1： | 2 |
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