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2篇 您的检索式：作者名="DENG Wanru"

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		题名	作者	年代	出处	被引量
	1	Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation显示文摘Objective: To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Methods: Publicly available database of Cancer Cell Line Encyclopedia(CCLE) was used in bioinformatic analyses. Methylation of Cp G islands was detected by denaturing high performance liquid chromatography(DHPLC). Gene transcript levels were determined using quantitative real-time polymerase chain reaction(q RTPCR) assays. An engineered P16-specific transcription factor and DNA methyltransferase were used to induce P16-specific DNA demethylation and methylation.Results: The expression level of ANRIL was positively and significantly correlated with that of P16 but not with that of P15 in the CCLE database. This was confirmed in human cell lines and patient colon tissue samples. In addition, ANRIL was significantly upregulated in colon cancer tissues. Transcription of ANRIL and P16 was observed only in cell lines in which the P16 alleles were unmethylated and not in cell lines with fully methylated P16 alleles.Notably, P16-specific methylation significantly decreased transcription of P16 and ANRIL in BGC823 and GES1 cells. In contrast, P16-specific demethylation re-activated transcription of ANRIL and P16 in H1299 cells(P<0.001).Alteration of ANRIL expression was not induced by P16 expression changes.Conclusions: ANRIL and P16 are coordinately transcribed in human cells and regulated by the methylation status of the P16 Cp G islands around the transcription start site.	Ying Gan Wanru Ma Xiuhong Wang Juanli Qiao Baozhen Zhang Chenghua Cui Zhaojun Liu Dajun Deng	2018	Chinese Journal of Cancer Research2018，30，1：	2
	2	Coupled Time-Domain Investigation on a Vertical Axis Wind Turbine Supported on a Floating Platform显示文摘The dynamic responses of a floating vertical axis wind turbine(VAWT)are assessed on the basis of an aero-hydro-mooring coupled model.The aerodynamic loads on the rotor are acquired with double-multiple stream tube method.First-and second-order wave loads are calculated on the basis of 3D potential theory.The mooring loads are simulated by catenary theory.The coupled model is established,and a numerical code is programmed to investigate the dynamic response of the semi-submersible VAWT.A model test is then conducted,and the numerical code is validated considering the hydrodynamic performance of the floating buoy.The responses of the floating VAWT are studied through the numerical simulation under the sea states of wind and regular/irregular waves.The effects of the second-order wave force on the motions are also investigated.Results show that the slow-drift responses in surge and pitch motions are significantly excited by the second-order wave forces.Furthermore,the effect of foundation motion on aerodynamic loads is examined.The normal and tangential forces of the blades demonstrate a slight increase due to the coupling effect between the buoy motion and the aerodynamic loads.	CUI Jianhui ZHAI Yongjian GUO Ying DENG Wanru LIU Liqin	2023	Journal of Ocean University of China2023，22，2：	1

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