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| 1 | Zircon SHRIMP U-Pb geochronology of the Neoproterozoic Chengjiang Formation in central Yunnan Province(SW China) and its geological significance显示文摘The Chengjiang Formation is the earliest continental clastic deposit after the Jinning Orogeny in central Yunnan Province,and therefore its accurate depositional age is significant for understanding the formation and evolution of the Neoproterozoic rift basins in southern China.However,hampered by accuracy of the dating technique,the existing age data for the Chengjiang Formation are not very reliable.A large number of magmatic zircons were obtained from the tuff interbed in the lower part of the Chengjiang Formation in Jinyang area and the bottom part of the Chengjiang Formation in Dongchuan area,central Yunnan Province,and high-precision SHRIMP U-Pb dating was carried out on these zircons.The results show that the weighted mean 206 Pb/238 U ages are 797.8±8.2 and 803.1±8.7 Ma respectively.In combination with related geological evidence,it has been demonstrated that the bottom boundary age of the Chengjiang Formation should be 800±5 Ma,whereas the top boundary age could be ca 725 Ma.By synthetically analyzing the latest age data for the relevant strata,it has been confirmed that the Chengjiang Formation should be correlated with the Suxiong Formation and the Kaijianqiao Formation in western Sichuan Province,the Liantuo Formation in the middle and lower Yangtze,the Hongchicun Formation and the Shangshu Formation in northern Zhejiang Province,the Puling Formation in southern Anhui Province,the Luokedong Formation and the Majianqiao Formation in northwestern Jiangxi Province,the Wuqiangxi Formation in northwestern Hunan Province,the Fanzhao Formation and the Qingshuijiang Formation in southeastern Guizhou Province,and the Sanmenjie Formation and the Gongdong Formation in northern Guangxi Province.Sedimentary cycle analysis shows that the sedimentary filling sequence of the Neoproterozoic rift basins in southern China can be divided into four cycles.Among them,Cycle II began at ca.800 Ma,accompanied by intensive tectonic-thermal events.The zircon U-Pb ages from the bottom of the Chengjiang Formation reported in this paper indicate that the Neoproterozoic Kangdian rift subbasin probably started to develop at ca.800 Ma and therefore missed Cycle I of the Neoproterozoic sedimentary filling sequence in southern China. | JIANG XinSheng WANG Jian CUI XiaoZhuang ZHUO JieWen XIONG GuoQing LU JunZe LIU JianHui | 2012 | Science China Earth Sciences2012，55，11： | 25 |
| 2 | Metal Flowing of Involute Spline Cold Roll-beating Forming显示文摘The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold roll-beating,etc.However,the research on law of metal flow in the forming process of involute spline cold roll-beating is rare.According to the principle of involute spline cold roll-beating,the contact model between the rollers and the spline shaft blank in the process of cold roll-beating forming is established,and the theoretical analysis of metal flow in the cold roll-beating deforming region is proceeded.A finite element model of the spline cold roll-beating process is established,the formation mechanism of the involute spline tooth profile in cold roll-beating forming process is studied,and the node flow tracks of the deformation area are analyzed.The experimental research on the metal flow of cold roll-beating spline is conducted,and the metallographic structure variation,grain characteristics and metal flow line of the different tooth profile area are analyzed.The experimental results show that the particle flow directions of the deformable bodies in cold roll-beating deformation area are determined by the minimum moving resistance.There are five types of metal flow rules of the deforming region in the process of cold roll-beating forming.The characteristics of involute spline cold roll-beating forming are given,and the forming mechanism of involute spline cold roll-beating is revealed.This paper researches the law of metal flow in the forming process of involute spline cold roll-beating,which provides theoretical supports for solving the tooth profile forming quality problem. | CUI Fengkui WANG Xiaoqiang ZHANG Fengshou XU Hongyu QUAN Jianhui LI Yan | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 19 |
| 3 | Opening time and filling pattern of the Neoproterozoic Kangdian Rift Basin,western Yangtze Continent,South China显示文摘The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation and evolution of the Yangtze Continent,South China.The Luliang Formation is the early filling in the eastern part of this rift basin,and its deposition age and filling sequence are significant for studies of the regional stratigraphic correlation,opening time,and filling pattern of this basin.Having been correlated to the upper part of the Mesoproterozoic Kunyang Group or to the Neoproterozoic Chengjiang Formation,the age and regional stratigraphic correlation of the Luliang Formation have long been uncertain.This is due to a lack of reliable absolute age constraints.To address this issue,the first zircon SHRIMP U-Pb geochronology has been established for this formation,yielding two high-precision isotopic ages of 818.6±9.2 and 805±14 Ma for the tuff layers at the bottoms of the lower and upper members of the Luliang Formation,respectively.Given the error factor,the bottom age of the lower member of the Luliang Formation can be interpreted as ca.820 Ma,corresponding to the bottom age of the lower part of the Banxi Group,which is the early filling of the Neoproterozoic Xianggui Rift Basin,a representative basin of the Neoproterozoic rift basins in the Yangtze Continent,South China.The bottom age of the upper member of the Luliang Formation can be interpreted as ca.800±5 Ma,corresponding to the bottom age of the Chengjiang Formation in the western part of the Neoproterozoic Kangdian Rift Basin and also corresponding to the bottom age of the upper part of the Banxi Group in the Neoproterozoic Xianggui Rift Basin.These ages indicate that the Neoproterozoic Kangdian Rift Basin shares the same opening time and filling sequences as those of the other Neoproterozoic rift basins in South China.Basin analysis shows that the Neoproterozoic Kangdian Rift Basin is a typical half-graben basin,with its main boundary fault in the west and basin center in the east.This basin consisted of mini unidirectional half-graben basins in its juvenile stage and simplified to become a large united half-graben basin in its mature stage,i.e.,a supradetachment basin. | ZHUO JieWen JIANG XinSheng WANG Jian CUI XiaoZhuang XIONG GuoQing LU JunZe LIU JianHui MA MingZhu | 2013 | Science China Earth Sciences2013，56，10： | 12 |
| 4 | Critical Role of Molecular Electrostatic Potential on Charge Generation in Organic Solar Cells显示文摘 | Huifeng Yao Deping Qian Hao Zhang Yunpeng Qin Bowei Xu Yong Cui Runnan Yu Feng Gao Jianhui Hou | 2018 | Chinese Journal of Chemistry2018，36，6： | 8 |
| 5 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020，7，7： | 7 |
| 6 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 7 | Effector cells derived from naive T cells used in tumor immunotherapy of mice bearing B16 melanoma显示文摘 | Wen Ming Xu Weili Ren Lili Gao Fei Cui Naipeng Wen Junye Li Xinjiang Lin Lin Ma Zhenfeng Chen Baoping Cai Jianhui | 2014 | Chinese Medical Journal2014，，7： | 1 |
| 8 | Optimizing polymer aggregation and blend morphology for boosting the photovoltaic performance of polymer solar cells via a random terpolymerization strategy显示文摘Compared to regular conjugated polymers,the random conjugated terpolymers are usually not beneficial to achieve highly efficient non-fullerene(NF)-based polymer solar cells(PSCs)due to their disordered chemical structures.In this work,we report two random terpolymer donors(PBNB80 and PBNB50)by tuning the molar ratio of electron-accepting units of 1,3-di(thiophen-2-yl)naphtho[2,3-c]thiophene-4,9-dione(NTD)and 1,3-bis(4-chlorothiophen-2-yl)-4 H,8 H-benzo[1,2-c:4,5-c’]dithiophene-4,8-dione(ClBDD),at the same time,the parent polymers(PBNB100 and PBNB00)are also compared to study.These four polymer donors exhibit similar optical bandgaps and gradually deepen highest occupied molecular orbital levels.Importantly,aggregation and self-organization properties of the random terpolymer donors are optimized,which result in the better morphology and crystal coherence length after blending with NF acceptor of BO-4 Cl.Particularly,a PBNB80:BO-4 Cl blend forms an optimal nanoscale phase-separation morphology,thereby producing an outstanding power conversion efficiency of 16.0%,which is much higher than those(12.8%and 10.7%)of their parent binary polymer donor-based devices.This work demonstrates that rational using terpolymerization strategy to prepare random terpolymer is a very important method to achieve highly efficient NF-PSCs. | Tao Zhang Cunbin An Qianglong Lv Jinzhao Qin Yong Cui Zhong Zheng Bowei Xu Shaoqing Zhang Jianqi Zhang Chang He Jianhui Hou | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 9 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 10 | A new redundant variable pruning approach*/minor latent variable perturbation_/PLS used for QSAR studies on anti-HIV drugs显示文摘 | Xie Hongping Jiang Jianhui Cui Hui | 2002 | Computers & Chemistry2002，26，： | 1 |
| 11 | Suppressing trap states and energy loss by optimizing vertical phase distribution through ternary strategy in organic solar cells显示文摘Suppressing the trap-state density and the energy loss via ternary strategy was demonstrated.Favorable vertical phase distribution with donors(acceptors)accumulated(depleted)at the interface of active layer and charge extraction layer can be obtained by introducing appropriate amount of polymer acceptor N2200 into the systems of PBDB-T:IT-M and PBDB-TF:Y6.In addition,N2200 is gradiently distributed in the vertical direction in the ternary blend film.Various measurements were carried out to study the effects of N2200 on the binary systems.It was found that the optimized morphology especially in vertical direction can significantly decrease the trap state density of the binary blend films,which is beneficial for the charge transport and collection.All these features enable an obvious decrease in charge recombination in both PBDB-T:IT-M and PBDB-TF:Y6 based organic solar cells(OSCs),and power conversion efficiencies(PCEs)of 12.5%and 16.42%were obtained for the ternary OSCs,respectively.This work indicates that it is an effective method to suppress the trap state density and thus improve the device performance through ternary strategy. | Pengqing Bi Shaoqing Zhang Tong Xiao Minghuan Cui Zhihao Chen Junzhen Ren Chaochao Qin Guanghao Lu Xiaotao Hao Jianhui Hou | 2021 | Science China Chemistry2021，64，4： | 1 |
| 12 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 13 | An improved Monte Carlo simulation method for discontinuity orientations based on Fisher distribution and its program implementation显示文摘 | Jun Zheng Jianhui Deng Xiaojuan Yang Jinbing Wei Hongchun Zheng Yulong Cui | 2014 | Computers and Geotechnics2014，，： | 1 |
| 14 | Simultaneous Optimization of Efficiency,Stretchability,and Stability in All-Polymer Solar Cells via Aggregation Control显示文摘With the emergence of Y-series small molecule acceptors,polymerizing the small molecule acceptors with aromatic linker units has attracted significant research attention,which has greatly advanced the photovoltaic performance of all-polymer solar cells.Despite the rapid increase in efficiency,the unique characteristics(e.g.,mechanical stretchability and flexibility)of all-polymer systems were still not thoroughly explored.In this work,we demonstrate an effective approach to simultaneously improve device performance,stability,and mechanical robustness of all-polymer solar cells by properly suppressing the aggregation and crystallization behaviors of polymerized Y-series acceptors.Strikingly,when introducing 50 wt%PYF-IT(a fluorinated version of PY-IT)into the well-known PM6:PY-IT system,the all-polymer devices delivered an impressive photovoltaic efficiency of 16.6%,significantly higher than that of the control binary cell(15.0%).Compared with the two binary systems,the optimal ternary blend exhibits more efficient charge separation and balanced charge transport accompanying with less recombination.Moreover,a high-performance 1.0 cm^(2)large-area device of 15%efficiency was demonstrated for the optimized ternary all-polymer blend,which offered a desirable PCE of 14.5%on flexible substrates and improved mechanical flexibility after bending 1000 cycles.Notably,these are among the best results for 1.0 cm^(2)all-polymer OPVs thus far.This work also heralds a bright future of all-polymer systems for flexible wearable energy-harvesting applications. | Kaihu Xian Kangkang Zhou Mingfei Li Junwei Liu Yaowen Zhang Tao Zhang Yong Cui Wenchao Zhao Chunming Yang Jianhui Hou Yanhou Geng Long Ye | 2023 | Chinese Journal of Chemistry2023，41，2： | 1 |
| 15 | Coupled Time-Domain Investigation on a Vertical Axis Wind Turbine Supported on a Floating Platform显示文摘The dynamic responses of a floating vertical axis wind turbine(VAWT)are assessed on the basis of an aero-hydro-mooring coupled model.The aerodynamic loads on the rotor are acquired with double-multiple stream tube method.First-and second-order wave loads are calculated on the basis of 3D potential theory.The mooring loads are simulated by catenary theory.The coupled model is established,and a numerical code is programmed to investigate the dynamic response of the semi-submersible VAWT.A model test is then conducted,and the numerical code is validated considering the hydrodynamic performance of the floating buoy.The responses of the floating VAWT are studied through the numerical simulation under the sea states of wind and regular/irregular waves.The effects of the second-order wave force on the motions are also investigated.Results show that the slow-drift responses in surge and pitch motions are significantly excited by the second-order wave forces.Furthermore,the effect of foundation motion on aerodynamic loads is examined.The normal and tangential forces of the blades demonstrate a slight increase due to the coupling effect between the buoy motion and the aerodynamic loads. | CUI Jianhui ZHAI Yongjian GUO Ying DENG Wanru LIU Liqin | 2023 | Journal of Ocean University of China2023，22，2： | 1 |
| 16 | Anticoagulation effect of low-dose and low-intensity heparin applied within 24 hours after intravenous thrombolysis for acute cerebral infarction显示文摘BACKGROUND:Studies have demonstrated that immediate anticoagulation after thrombolysis can improve the prognosis of patients with acute cerebral infarction. However,the optimal timing and means of anticoagulation therapy remain unclear. OBJECTIVE:To observe the effects and safety of heparin treatment within 24 hours after intravenous thrombolysis for acute cerebral infarction. DESIGN:Observation experiment. SETTING:Department of Neurology,the 306 Hospital of Chinese PLA. PARTICIPANTS:Fifteen acute cerebral infarction patients complicated by moderate and severe neurologic function deficits within 6 hours after attack admitted to Department of Neurology,the 306 Hospital of Chinese PLA between January 2005 and December 2006 were recruited in this study. The involved patients,11 male and 4 female,were aged 46-79 years. They all met the diagnosis criteria for various cerebrovascular diseases formulated by the 4th National Conference for Cerebrovascular Disease(1995) and confirmed as cerebral infarction by skull CT or MRI imageology. Informed consents were obtained from the patients or their relatives. METHODS:On admission,patients received thrombolysis with urokinase. Immediately after thrombolysis,skull CT was rechecked. Intracranial hemorrhage signs were not found by skull CT. Hemorrhage was also not found in skin,mucous membrane and internal organs. Six hours later,low-dose low-intensity heparin 4-8 IU/kg per hour was intravenously administrated for anticoagulation for 7-10 days successively. MAIN OUTCOME MEASURES:Neurologic function was evaluated before,immediately 6 hours and 14 days after thrombolysis by scoring standard of clinical neurologic function deficit degree for stroke patients(1995). Activities of daily living of patients with stroke were evaluated 90 days after thrombolysis by modified Rankin Scale. RESULTS:Fifteen involved patients participated in the final analysis. ① Comparison of clinical neurologic function deficit degree of patients at different time:Neurologic function deficit score at the end of thrombolysis was significantly lower than that before thrombolysis(t =3.45,P < 0.01). Neurologic function deficit score 6 hours after thrombolysis was higher than that at the end of thrombolysis,and neurologic deficits were increased,but no significant difference was found(P > 0.05). Neurologic function deficit score 14 days after thrombolysis was significantly lower than that before thrombolysis(t =4.769,P < 0.01). ② Therapeutic effect and modified Rankin scale results:14 days after thrombolysis,4 patients were basically cured,7 significantly improved,2 improved and 2 worsened. The total improvement rate of neurologic function deficit was 86.7%. Ninety days after thrombolysis,according to modified Rankin Scale,score was 0 to 2 in 12 patients(80%),3 to 4 in 2 patients(13.3%) and 6 in 1 patient(6.7%). Complications of intracranial hemorrhage were not found in patients within 14 days after thrombolysis. CONCLUSION:Low-dose and low-intensity heparin applied within 24 hours after intravenous thrombolysis has good safety and efficacy in the treatment of acute cerebral infarction. | Juan Du Yiling Cai Wei Li Yongqiang Cui Qiao Wu Jianhui Cai | 2007 | Neural Regeneration Research2007，2，11： | 0 |
| 17 | Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses显示文摘A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion ability.To evaluate its antigenicity relationship with other variants,antisera from guinea pigs immunized with spike protein of SARS-CoV-2 variants of concern(VOCs)and variants of interest(VOIs)were cross-tested against pseudotyped variants.The neutralization activity against Omicron was markedly reduced when other VOCs or VOIs were used as immunogens,and Omicron(BA.1)-elicited sera did not efficiently neutralize the other variants.However,a Beta or Omicron booster,when administered as the 4th dose 3-months after the 3rd dose of any of the variants,could elicit broad neutralizing antibodies against all of the current variants including Omicron BA.1.Further analysis with 280 available antigen–antibody structures and quantification of immune escape from 715 reported neutralizing antibodies provide explanations for the observed differential immunogenicity.Three distinct clades predicted using an in silico algorithm for clustering of sarbecoviruses based on immune escape provide key information for rational design of vaccines. | Qianqian Li Li Zhang Ziteng Liang Nan Wang Shuo Liu Tao Li Yuanling Yu Qianqian Cui Xi Wu Jianhui Nie Jiajing Wu Zhimin Cui Qiong Lu Xiangxi Wang Weijin Huang Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 18 | Theoretical elucidation of rare earth extraction and separation by diglycolamides from crystal structures and DFT simulations显示文摘Diglycolamides(DGAs) show excellent application prospects for the extraction and separation of rare earth metals from highly radioactive liquid wastes and rare earth ores.The extraction ability of DGAs for rare earth ions in nitrate or chloride media increases with increasing atomic number of the rare earth metal.To understand the origin of this phenomenon,three binuclear crystals [Ln(TEDGA)_(3)][Ln(NO_(3))_(6)] of N,N,N’,N’-tetraethyldiglycolamide(TEDGA) with rare earth ions La(Ⅲ),Pr(Ⅲ) and Eu(III) were prepared and characterized crystallographically.The three complexes belong to the triclinic crystal system,P-1 space group.The bond lengths of Ln-O_(amide) are significantly shorter than those of Ln-O_(ether) in the same crystal.The Ln-O_(amide) and Ln-O_(enher) bond lengths gradually decrease with increasing atomic number of the rare earth ion.The dihedral angle formed by TEDGA and metal ions through the tridentate coordination gradually increases with increasing metal ion atomic number,tending toward the formation of sizeable planar coordination structures for the most massive rare earth ions.The structures of the compounds formed by the extractant and metal ion were optimized by means of DFT simulations.We find that the interaction between TEDGA and the rare earth ion is dominated by electrostatic interaction by analyzing binding energy,WBIs,Mulliken charge,natural electron configurations,and molecular orbital interaction.The covalent component of the Ln-O bonds of the complexes increases with increasing metal atomic number.The observed increase in extraction and separation capacity of diglycolamides for rare earth ions with increasing atomic number might be due to the formation of two fivemember rings by one tridentate ligand.The rare earth ions with large atomic numbers tend to form planar structures with large dihedral angles with DGA ligands. | Xiujing Peng Jianhui Su Hao Li Yu Cui Jin Yong Lee Guoxin Sun | 2021 | Journal of Rare Earths2021，39，7： | 0 |
| 19 | Hyperbranched magnetic polymer:highly efficient removal of Cr(Ⅵ)and application in electroplating wastewater显示文摘By using a two-step hydrothermal method and trithiocyanuric acid(TTCA),2,4,6-trihydrazino-1,3,5-triazine(THT),and Fe_(3)O_(4)as raw materials,a spherical magnetic adsorbent polymer(TTCA/THT@Fe_(3)O_(4))was synthesized to achieve the efficient removal of Cr(VI)from wastewater.Under optimal adsorption conditions,the maximum adsorption capacity of TTCA/THT@Fe_(3)O_(4)for Cr(VI)can reach 1340 mg∙g‒1.Notably,the removal efficiency can approach 98.9%,even at the lower concentration of 20 mg∙L^(‒1)Cr(VI).For actual wastewater containing Cr(VI),the Cr(VI)concentration was reduced from 25.8 to 0.4 mg∙L^(‒1),a remarkable 20%lower than the current industry discharge standard value.A mechanism for the high adsorption performance of Cr(VI)on TTCA/THT@Fe_(3)O_(4)was investigated using Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,and density functional theory.It can be plausibly attributed to the formation of Cr/N and Cr/S coordination bonds.Additionally,surface electrostatic adsorption,reduction effects,and the spherical polymer structure increase the contact area with Cr(VI),maximizing adsorption.The synergistic effect of adsorption and reduction enhances the adsorption performance of TTCA/THT@Fe_(3)O_(4)for Cr(VI)and total chromium in water.The resultant polymer has a simple preparation process,excellent adsorption performance,easy magnetic separation,and promising application for actual wastewater. | Nan Sun Qing Wu Lifang Jin Zichen Zhu Jianhui Sun Shuying Dong Haijiao Xie Chunyan Zhang Yanrui Cui | 2023 | Frontiers of Chemical Science and Engineering2023，17，10： | 0 |
| 20 | Engineering G-quadruplex aptamer to modulate its binding specificity显示文摘The use of aptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein receptors.Targeted therapeutics and theranostics come to mind in this regard.However,protein receptors occur on both cancer and normal cells;as such,aptamers are now taxed with identifying high vs.low levels of protein expression.Inspired by the flexible template mechanism and elegant control of natural nucleic acid-based structures,we report an allosteric regulation strategy for constructing a structure-switching aptamer for enhanced target cell recognition by engineering aptamers with DNA intercalated motifs(i-motifs)responsive to the microenvironment,such as p H.Structure-switching sensitivity can be readily tuned by manipulating i-motif sequences.However,structure-switching sensitivity is difficult to estimate,making it equally difficult to effectively screen modified aptamers with the desired sensitivity.To address this problem,we selected a fluorescent probe capable of detecting G-quadruplex in complicated biological media. | Long Li Shujuan Xu Xueyu Peng Yuzhuo Ji He Yan Cheng Cui Xiaowei Li Xiaoshu Pan Lu Yang Liping Qiu Jianhui Jiang Weihong Tan | 2021 | National Science Review2021，8，4： | 0 |
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