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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Correlation between water diffusion and adhesion loss: Study of an epoxy primer on steel显示文摘 | Elise Legghe Emmanuel Aragon Léna?k Bélec André Margaillan Denis Melot | 2009 | Progress in Organic Coatings2009，，3： | 2 |
| 3 | Molecular interactions be- tween apoE and ABCA1 : impact on apoE lipidation 显示文摘 | Krimbou L Denis M Haidar B | 2004 | J Lipid Res2004，45，： | 1 |
| 4 | Patterns of skin diseases in the elderly 显示文摘 | Perrot JL Labeille B Denis Thely L | 2008 | Ann Dermatol Venereol2008，135，5： | 1 |
| 5 | Prognostic value of ambulatory blood- pressure recordings in patients with treated hypertension显示文摘 | Denis L Marc L De Buyzere B | 2003 | N Engl J Med2003，348，12： | 1 |
| 6 | Presence of microcysts within a cystic tumor of the pancreas does not rule out malignancy: report of two cases显示文摘 | Denis B Claudel L Marcellin L | 2003 | Gastroenterol Clin Biol2003，27，67： | 1 |
| 7 | High Performance Liquid Chromatographic Determination of Flumetsulam, A Newly Developed Sulfonamide Herbicide in Soil 显示文摘 | Sundaram B Denis R L Patrick T H | 1996 | Journal of Chromatography A1996，746，： | 1 |
| 8 | Problem -based and project - based learning in engineering and medicine: Determinants of students' engagement and persistance 显示文摘 | Denis B Christelle L Dmliel D | 2012 | Interdisciplinary Journal of Problem - based Learning2012，，2： | 1 |
| 9 | cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts显示文摘 | Haidar B Denis M Krimbou L | 2002 | J Lipid Res2002，43，12： | 1 |
| 10 | Synthesis and Characterization of Some 4-Keto Derivatives of 1,3,4 (2H) - Isoquinolinetrione Redox Mediator Herbicides显示文摘 | CLEMENS L ELKE H DENIS B | 2000 | Pest Manage Sci2000，56，： | 1 |
| 11 | Prognostic value of anbulatory blood-pressure recordings in patients with treated hypertension显示文摘 | Denis L Marc L De Buyzere B | 2003 | N Engl J Med2003，348，： | 1 |
| 12 | Axial coordinationof ferric Aplysia myoglobin显示文摘 | Denis L R Ching Y C Maurizio B | 1989 | The Journal of BiologicalChemistry1989，264，14： | 1 |
| 13 | A morphology-based approach for interslice interpolation of anatomical slice from volumetric images 显示文摘 | Alexandra B A Trevor B Denis L | 2008 | IEEE Trans on Biomedical Engineering2008，55，8： | 1 |
| 14 | In situ oxygen uptake rates by coastal sediments under the influence of the Rhone River ( NW Mediterranean Sea) 显示文摘 | Lansaed B Rabouille C Denis L 2008 | 2008 | Continental Shelf Research2008，28，12： | 1 |
| 15 | Human cytomegalovirus quantification in toddlers salivafrom day care centers and emergency unit: a feasibilitystudy 显示文摘 | Grosjean J Trapes L Hantz S Mengelle C Virey B Undreiner F Messager V Denis F Marin B Alain S | 2014 | J Clin Virol2014，61，3： | 1 |
| 16 | Prognostic value of ambulatory blood-pressure recordings in patients with treatod hypertension显示文摘 | Denis L Marc L De Buyzere B | 2003 | N Engl J Med2003，348，： | 1 |
| 17 | Synthesis and characterization of some 4-keto derivatives of 1,3,4 (2H) -isoquinolinetrione redox mediator herbicides显示文摘 | Clemens L Elke H Denis B | 2000 | Pest Manage Sci2000，56，： | 1 |
| 18 | Relationship between complement activation cellular uptake and surface physicochemical aspects of novel PEG-modified neanocapsules 显示文摘 | Ruxandraq G Denis L Gillian B | 2001 | Biomaterials2001，，22： | 1 |
| 19 | On the safe use of long-rangelaser active imager in the near-infrared for homeland se- curity显示文摘 | DENI B SYLVIANE L LOUIS D | 2006 | SPIE2006，6406，： | 1 |
| 20 | In situ oxygen uptake rates by coastal sediments under the influence of the Rhone River ( NW Mediterranean Sea) 显示文摘 | LANSARD B RABOUILLE C DENIS L | 2008 | Continental Shelf Research2008，28，12： | 1 |
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