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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 3 | Thermochemistry and aqueous solubilities of hydrotalcitelike solids显示文摘 | Rama Kumar A Alexandra N Hillary T B William H C | | 0，，5568： | 1 |
| 4 | Vapor Recovery of Natural Gas Using Non - Mechanical Technology 显示文摘 | Mark A Alexandra L john B | 2003 | SPE 805992003，，： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | Kinetic determination of trace amounts of Cu (Ⅱ) in water based on its catalytic effect on the reation of mercaptosuccinic acid and Cr (Ⅵ)显示文摘 | Alexandra A R loan S B Dana D M | 2002 | Mierochim Acta2002，140，： | 1 |
| 7 | Evaluating shortfalls in mixed-integer programming approaches for the optimal design and dispatch of distributed generation systems 显示文摘 | KRISTOPHER A P ROBERT J B ALEXANDRA M | 2013 | Applied Energy2013，102，： | 1 |
| 8 | A morphology-based approach for interslice interpolation of anatomical slice from volumetric images 显示文摘 | Alexandra B A Trevor B Denis L | 2008 | IEEE Trans on Biomedical Engineering2008，55，8： | 1 |
| 9 | A morphology-based approach for interslice interpolation of anatomi- cal slice from volumetric images 显示文摘 | ALEXANDRA B A TREVOR B DENIS L | 2008 | IEEE Transactions on Biomedical Engineering2008，55，8： | 1 |
| 10 | Continuous analog of the Gauss-Newton method 显示文摘 | RUBEN G A ALEXANDER G R ALEXANDRA B S | 1999 | Mathematical Models and Methods in Applied Sciences1999，9，3： | 1 |
| 11 | Gas permeation parameters of mixed matrix membranes based on the polymer of intrinsic microporosity PIM - 1 and the zeolitic imidazolate framework ZIF - 8 显示文摘 | Alexandra F B Martin P A Christopher R M | 2013 | Journal of Membrane Science2013，427，1： | 1 |
| 12 | Assessment of the Tissue distribution of transplanted human endothelial progeniter cells by radioactive labeling显示文摘 | ALEXANDRA A WINFRIED B MAAZ Z | 2003 | Circulation2003，107，： | 1 |
| 13 | Endothelial and nonendothelial sources of PDGF2B regulate pericyte recruitment and influence vascular pattern formation in tumors显示文摘 | Alexandra A Per L Christer B | 2003 | J Clin Invest2003，112，8： | 1 |
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