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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Spiral CT cholangiography of choledochocele显示文摘 | Galeon M Deprez P Wan-Beers B E | 1996 | J-Comput-Assist-Tomogr1996，20，5： | 1 |
| 3 | Clinical spectrum of early-onset epileptic encephalopathies associated with STXBPI muta- tions 显示文摘 | Deprez L Weckhuysen S Holmgren P | 2010 | Neurology2010，75，13： | 1 |
| 4 | Squalene content and neutral lipid composition of livers from deep-sea sharks caught in Tasmanian waters 显示文摘 | Deprez P P Volkman J K Davenport S R | 1990 | Aust J Mar Freshwater Res1990，41，3： | 1 |
| 5 | Endoscopic ultrasound guided fine needle aspiration in biliary and pancreatic diseases: pitfalls arid performan- ces显示文摘 | Weynand B Deprez P | 2004 | Acta Gastroenterol Belg2004，67，3： | 1 |
| 6 | Heartburn in Belgium:prevalence,impact on daily life,and utilization of medical resources显示文摘 | Louis E DeLooze D Deprez P | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
| 7 | Healing of severe esophagitis improvesesophageal peristaltic dysfunction显示文摘 | Deprez P Fiasse R | | 0，，： | 1 |
| 8 | Genetics of epilepsy syndromes starting in the first year of life 显示文摘 | Deprez L Jansen A De Jonghe P | 2009 | Neurology2009，72，： | 1 |
| 9 | Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations显示文摘 | Deprez L Weckhuysen S Holmgren P | 2010 | Neurology2010，75，13： | 1 |
| 10 | A novel GABRG2 mutation associated with febrile seizures显示文摘 | D Audenaert E Schwartz K G. Claeys L Claes L Deprez A Suls T Van Dyck L Lagae C Van Broeckhoven R L. Macdonald P De Jonghe | 2006 | Neurology2006，，4： | 1 |
| 11 | A case report of desmoid tumor of the finger显示文摘 | Berthe JV Lorea P Deprez C | 2003 | Chit Main2003，22，6： | 1 |
| 12 | Prospective randomized comparison between EMR and ESD for endoscopic removal of superficial esophageal cancer 显示文摘 | Deprez P H Yeung R C Aouattah T | 2008 | Gastrointest Endosc2008，67，5： | 1 |
| 13 | Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resources显示文摘 | LOUIS E DELOOZE D DEPREZ P | 2002 | Eur J Gastroenterol Hepatol2002，14，3： | 1 |
| 14 | Study of glass-ceramic materials interfaces显示文摘 | Vantomme P Deprez P Comet A | 1998 | Materials Letters1998，36，56： | 1 |
| 15 | Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations显示文摘 | Deprez L Weckhuysen S Holmgren P | 2010 | Neurol2010，75，13： | 1 |
| 16 | Liquid verus dry feeding in weaned piglet:The influence on small intestinal morphology显示文摘 | Depreze P | 1987 | Vet Med Biol1987，34，： | 1 |
| 17 | Non-radioactive in situ detection of mRNA in ES cell-derived cardiomyocytes and in the developing heart显示文摘 | FIJNVANDRAAT A C DE BOER P A DEPREZ R H | 2002 | Microsc Res Tech2002，58，： | 1 |
| 18 | Transcra- nial magnetic stimulation: normal values of magnetic motor evoked potentials in 84 normal horses and in- fluence of height, weight, age and sex显示文摘 | Nollet H Deprez P van Ham L et a! | 2004 | Equine Vet J2004，36，1： | 1 |
| 19 | Clinical spectrum of early-onset epileptic eneephalopathies associated with STXBP1 mu- tations显示文摘 | Deprez L Weckhuysen S Holmgren P | 2010 | Neurology2010，75，13： | 1 |
| 20 | Squalene content and neutral lipid composition of livers from deep-sea sharks caught in Tasmanian waters显示文摘 | DEPREZ P P VOLKMAN J K DAVENPORT S R | 1990 | Aust J Mar Freshwater Res1990，41，3： | 1 |
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