|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | Overlap syndrome consisting of PSC-AIH with concomitant presence of a membranous glomerulonephritis and ulcerative colitis显示文摘The association of primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)is known as an overlap syndrome(OS).OS can also be described in the setting of concomitant presence of AIH and PSC.These diseases can in some cases be associated with ulcerative colitis.In this case report we describe,to our knowledge,the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association betweenPSC-AIH,with the concomitant presence of a membranous glomerulonephritis. | Odile Warling Christophe Bovy Carla Combra Timothée Noterdaeme Jean Delwaide Edouard Louis | 2014 | World Journal of Gastroenterology2014，20，16： | 4 |
| 3 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 4 | Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy显示文摘背景本地复发在经历胸保守人士外科的病人之中仍然是一个严重问题。这研究瞄准了在这回顾的研究基于的胸保守人士 surgery.Methods 以后为剩余疾病识别风险因素收到了胸保守人士外科和随后的结束乳房切除术的有侵略乳癌的病人。所有病人在起始的操作有清楚的切除术边缘。我们在结束乳房切除术和下列风险因素期间分析了在剩余疾病的存在之间的协会:广泛的 intraductal 部件(EIC ) 的 T 阶段,年轻年龄,和存在,靠近的边缘, lymphovascular 浸透(LVP ) ,雌激素受体的确实,孕酮受体,和 c-erbB-2.Results 剩余疾病在 21 被遇到(45.7%) 46 个病人;EIC 在 28 个病人(60.9%) 是在场的,谁 17 有的剩余疾病。EIC 的存在在结束乳房切除术(P=0.011 ) 期间与剩余疾病的更高的风险在胸保存外科期间被联系。另外的变量不是为剩余疾病的存在的统计上重要的风险因素。在结束乳房切除术为有有 EIC 的存在是的 not.Conclusions 的剩余疾病和那些的病人是类似的以后,没有本地复发在我们的队,和没有疾病的幸存和全面幸存被记录为在在胸保守人士外科以后的病人的剩余疾病的一个重要风险因素。我们的调查结果可以在起始的胸保守人士外科期间与 EIC 在病人建议结束乳房切除术的显示的价值减少随后的本地失败的风险。 | Christopher C. E Yiu Wings T. Y. Loo C. K. Lam Louis W. C. Chow | 2009 | Chinese Medical Journal2009，，8： | 4 |
| 5 | Effects of Branching Architecture on the Reactivity of Epoxy-Amine Groups显示文摘 | Raffaele Mezzenga Louis Boogh Jan-Anders E | 2000 | Macromolecules2000，33，： | 3 |
| 6 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 7 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2006 | Journal of Vascular and Interventional Radiology2006，，3： | 3 |
| 8 | Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x 显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | Chemical Communication1977，，： | 2 |
| 9 | Anti-inflammatory and analgesic activities of Melanthera scandens显示文摘Objective:To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens(M.scandens).Methods:The crude leaf extract(39-111 mg/kg)of M.scandens was investigated for anti-inflammatory and analgesic activities using various experimental models.The anti-inflammatory activity was investigated using carragenin,egg-albumin induced oedema models,while acetic acid,formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.Results:The extract caused a significant(P<0.05-0.001)dose-dependent reduction of inflammation and pains induced by different agents used.Conclusions:The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant. | Jude E Okokon Anwanga E Udoh Samuel G Frank Louis U Amazu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 2 |
| 10 | Is the negative prognostic impact of signet ring cell histology maintained in early gastric adenocarcinoma?显示文摘 | Caroline Gronnier Mathieu Messager William B. Robb Timothée Thiebot Damien Louis Guillaume Luc Guillaume Piessen Christophe Mariette | 2013 | Surgery2013，，： | 2 |
| 11 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 12 | Designing flexible manipulators with the lowest natural frequency nearly independent of position显示文摘 | LOUIS J E JENNCHEN T MARC C | 1999 | IEEE Transaction on Robotics and Automation1999，15，4： | 1 |
| 13 | Tumor necrosis factor(TNF) gene polymorphism influences TNF-alpha production in lipoplysaccharide(LPS)-stimulated whole blood cell culture in healthy humans显示文摘 | Louis E Franchimont D Piron A | 1998 | Clin Exp Immunol1998，113，3： | 1 |
| 14 | Characterization of the microstructure of a commerical Al-Cu alloy (2011) by differential scanning calorimetry (DSC)显示文摘 | Cordovilla C G Louis E | 1984 | J Material Science1984，19，： | 1 |
| 15 | Effects of spray characteristics on critical heat flux in subcooled water spray cooling 显示文摘 | Ruey Hung Chen Louis C Chow Jose E Navedo | 2002 | International Journal of Heat and Mass Transfer2002，45，： | 1 |
| 16 | Congenital hand and forearm anomalies显示文摘 | Louis DS Tsai E | 1996 | Curr ()pin Pediatr1996，8，1： | 1 |
| 17 | Early postnatal food intake alters myofiber maturation in pig skeletal muscle1显示文摘 | LOUIS L PATRICK E YVES M B | 2003 | The Journal of Nutrition2003，133，1： | 1 |
| 18 | Tumor necrosis factor gene polymorphism influences TNF alpha produc-tion in LPS-stimulated whole blood cell culture in healthy humans显示文摘 | Louis E Franchimont D Piron A | | 0，，3： | 1 |
| 19 | Understanding the new allele prob-lem显示文摘 | Klitz W Hedrick P Louis E | 2011 | Tissue Antigens2011，77，5： | 1 |
| 20 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员