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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Tibetan, Variscan, and Precambrian reactivation: Products of continental collision 显示文摘 | Dewey J F Burke K C A | 1973 | Jour Geol1973，81，： | 1 |
| 3 | Recent secular variations in the extent of Northern Hemisphere snow cover显示文摘 | ROBINSON D A DEWEY K F | 1990 | Geophysical Research Letters1990，17，10： | 1 |
| 4 | Does birth spacing affect maternal or child nutritional status? a systematic literature review 显示文摘 | DEWEY K G COHEN R J | 2007 | Maternal and Child Nutrition2007，3，3： | 1 |
| 5 | Global snow cover monitoring:An Update显示文摘 | Robinson D A Dewey K F Heim R R | 1993 | Bulletin of the American Meteorological Society1993，74，9： | 1 |
| 6 | Global snow cover monitoring:An update显示文摘 | Robinson D Dewey K Heim R | 1993 | Bulletin of American Meteorological Society1993，74，9： | 1 |
| 7 | Protein requirements ofinfants and children显示文摘 | DEWEY K G BEATON G FJELD C | 1996 | European Journal of Clinical Nutrition1996，50，1： | 1 |
| 8 | Global snow cover mo- nitoring: an update显示文摘 | Robinson D A Dewey K F Heim R R | 1993 | Bulletin of the American Meteorological Society1993，74，： | 1 |
| 9 | Social network development, language use, and language ac- quisition during study abroad: Arabic language learners' perspectives显示文摘 | Dewey D P Belnap R K Hillstrom R | 2013 | Frontiers: The interdisciplinary journal of study abroad2013，22，： | 1 |
| 10 | Health advantages of breastfeeding for infants:a critical review显示文摘 | HEINIG M J DEWEY K G | 1996 | Nutr Res Rev1996，9，： | 1 |
| 11 | Recent secular variations in the extenl of Northern Hemisphere snow cover 显示文摘 | Robinson D A Dewey K F | 1990 | Geophysical Research Letters1990，17，10： | 1 |
| 12 | Global snow covermonitoring j an update显示文摘 | Robinson D A Dewey K F Heim Jr R R | 1993 | Bulletin of the American Meteoro-logical Society1993，74，9： | 1 |
| 13 | Global snow cover monitoring: an update显示文摘 | Robinson D A Dewey K F Heim R R | 1993 | Bulletin of the American Meteoro- logical Society1993，74，9： | 1 |
| 14 | Protein and amino acids显示文摘 | | 2000 | Pediatrics2000，106，5： | 1 |
| 15 | Tibetan, Variscan, and Precambrian Basement ReactiVation: Products of Continental Collision显示文摘 | DEWEY J F BURKE K C A | 1973 | Journal of Geology1973，81，： | 1 |
| 16 | Risk Factors for Suboptimal Infant Breastfeeding Behavior, De- layed Onset of Lactation, and Excess Neonatal Weight Loss 显示文摘 | Dewey K G Nommsen-Rivers L A Heinig M J | 2003 | Pediatrics2003，112，31： | 1 |
| 17 | Global warming and the export of dissolved organic carbon from boreal peatlands 显示文摘 | Pastor J Solin J Bridgham S D Updegraff K Harth C Weishampel P Dewey B | 2003 | Oikos2003，100，2： | 1 |
| 18 | Effects of age of introduction of complementary foods on iron status of breast - fed infants in Honduras显示文摘 | DEWEY K G COHEN R J RIVERA L L | 1998 | Am J Clin Nutr1998，67，5： | 1 |
| 19 | Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss显示文摘 | DEWEY K G NOMMSEN-RIVERS L A HEINIG M J | 2003 | Pediatrics2003，112，3： | 1 |
| 20 | Global snow cover monitoring:an update显示文摘 | Robinson D A Dewey K F Heim R R J | 1993 | Bull Amer Meteor Soc1993，74，9： | 1 |
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