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| 1 | Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment显示文摘Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses. | Francesca R Ponziani Maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini | 2010 | World Journal of Gastroenterology2010，16，2： | 75 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 5 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 3 |
| 6 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 7 | Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in celiac disease显示文摘 | Di Sabatino A Ciccocioppo R D'Alo S | 2001 | Gut2001，49，3： | 2 |
| 8 | Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization显示文摘 | Kurz A Sessler DI Lenhardt R | 1996 | New Engl J Med1996，334，： | 1 |
| 9 | Molecular mechanisms of acute renal failure following ischemia reperfusion显示文摘 | VRTDYRILRN A M DI - MAGGIO F LEEMREIS J R | 2004 | Int J Artif Organs2004，27，12： | 1 |
| 10 | Infalmmatory cytokines in acute ischemic stroke 显示文摘 | Tuttolomondo A Di Raimondo D di Sciacea R | 2008 | Curr Pharm Desl2008，14，33： | 1 |
| 11 | The effect ofsubclinical hypothyroidism on metabolic control in chil-dren and adolescents with Type 1diabetes mellitus显示文摘 | Mohn A Di Michele S Di luzio R | 2002 | Diabet Med2002，19，1： | 1 |
| 12 | Canine piroplasmosis in Italy: epidemiological aspects in vertebrate and in- vertebrate hosts 显示文摘 | Cassini R Zanutto S Frangipane di Regalbono A | 2009 | Vet Parasitol2009，165，12： | 1 |
| 13 | Fluoranthene, but not benzopyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish显示文摘 | MATSON C W TIMME-LARAGY A R DI GIULIO R T | 2008 | Chemosphere2008，74，1： | 1 |
| 14 | Pro-and anti-apoptotic effects of p53 in cisplatin-treated humantesticular cancer are cell context-dependent显示文摘 | di Pietro A Koster R Boersma-van Eck W | 2012 | Cell Cy-cle2012，11，24： | 1 |
| 15 | Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis 显示文摘 | Graceffa D Amorosi B Maiani E Bonifati C Cbi menti MS Perrieone R Di Carlo A | 2013 | Arthritis2013，，95： | 1 |
| 16 | Mechanisms of villous atrophy in autoimnmne enteropathy and coeliac disease 显示文摘 | Ciccocioppo R D'AIo S Di Sabatino A | 2002 | Clin Exp hnmunol2002，128，1： | 1 |
| 17 | Anti-Mullerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization显示文摘 | Fanchin R Mendez LD Frydman N Gougeon A di Clemente N Frydman R Taieb J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 18 | Infalmma- tory cytokines in acute ischemic stroke 显示文摘 | Tuttolomondo A Di Raimondo D bi Sciacca R | 2008 | Curr Pharm Desh2008，14，33： | 1 |
| 19 | Morgana/chp-1,a ROCK inhibitor involved in centrosome duplication and tumorigenesis显示文摘 | Ferretti R Palumbo V Di Savino A | 2010 | Dev Cell2010，18，3： | 1 |
| 20 | β-amyloid deposition in brain is enhanced in mouse models of arterial hypertension显示文摘 | Gentile MT Poulet R Di Pardo A | 2009 | Neurobiol Aging2009，30，2： | 1 |
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