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| 1 | Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment显示文摘Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses. | Francesca R Ponziani Maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini | 2010 | World Journal of Gastroenterology2010，16，2： | 75 |
| 2 | Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate显示文摘Alterations of intestinal microflora may significantly contribute to the pathogenesis of different inflammatory and autoimmune disorders. There is emerging interest on the role of selective modulation of microflora in inducing benefits in inflammatory intestinal disorders, by as probiotics, prebiotics, synbiotics, antibiotics, and fecal microbiota transplantation(FMT). To summarize recent evidences on microflora modulation in main intestinal inflammatory disorders, Pub Med was searched using terms microbiota, intestinal flora, probiotics, prebiotics, fecal transplantation. More than three hundred articles published up to 2015 were selected and reviewed. Randomized placebo-controlled trials and meta-analysis were firstly included, mainly for probiotics. A meta-analysis was not performed because of the heterogeneity of these studies. Most of relevant data derived from studies on probiotics, reporting some efficacy in ulcerative colitis and in pouchitis, while disappointing results are available for Crohn's disease. Probiotic supplementation may significantly reduce rates of rotavirus diarrhea. Efficacy of probiotics in NSAID enteropathy and irritable bowel syndrome is still controversial. Finally, FMT has been recently recognized as an efficacious treatment for recurrent Clostridium difficile infection. Modulation of intestinal flora represents a very interesting therapeutic target, although it still deserves some doubts and limitations. Future studies should be encouraged to provide new understanding about its therapeutical role. | Antonella Gallo Giovanna Passaro Antonio Gasbarrini Raffaele Landolfi Massimo Montalto | 2016 | World Journal of Gastroenterology2016，22，32： | 19 |
| 3 | Ethanol injection is highly effective for hepatocellular carcinoma smaller than 2cm显示文摘AIM:To analyze the long-term prognosis in a cohort of western cirrhotic patients with single hepatocellular carcinoma treated with ethanol injection.METHODS:One-hundred forty-eight patients with solitary hepatocellular carcinoma were enrolled.The tumor diameter was lower than 2 cm in 47 patients but larger in the remaining 101 patients.The impact of some pretreatment clinical and laboratory parameters and of tumor recurrence on patients' survival was assessed.RESULTS:Among the pre-treatment parameters,only a tumor diameter of less than 2 cm was an independent prognostic factor of survival.The occurrence of new nodules in other liver segments and the neoplastic portal invasion were linked to a poorer prognosis at univariate analysis.Patients with a single hepatocellular carcinoma smaller than 2 cm showed a better 5-year cumulativesurvival(73.0% vs 47.9%)(P = 0.009),3-year local recurrence rate(29.1% vs 51.5%)(P = 0.011),and 5-year distant intrahepatic recurrence rate(52.9% vs 62.8%)(P = 0.054) compared to patients with a larger tumor.CONCLUSION:The 5-year survival rate of patients with single hepatocellular carcinoma < 2 cm undergoing ethanol injection is excellent and comparable to that achieved using radiofrequency ablation. | Maurizio Pompili Erica Nicolardi Valeria Abbate Luca Miele Laura Riccardi Marcello Covino Nicoletta De Matthaeis Antonio Grieco Raffaele Landolfi Gian Ludovico Rapaccini | 2011 | World Journal of Gastroenterology2011，17，26： | 6 |
| 4 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 3 |
| 5 | Liver Transplantation in Alcoholic Patients: Impact of an Alcohol Addiction Unit Within a Liver Transplant Center显示文摘 | Giovanni Addolorato Antonio Mirijello Lorenzo Leggio Anna Ferrulli Cristina D’Angelo Gabriele Vassallo Anthony Cossari Giovanni Gasbarrini Raffaele Landolfi Salvatore Agnes Antonio Gasbarrini | 2013 | Alcohol Clin Exp Res2013，，9： | 2 |
| 6 | Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori显示文摘 | Antonio Gasbarrini Francesco Franceschi Raffaele Tartaglione Raffaele Landolfi Paolo Pola Giovanni Gasbarrini | 1998 | The Lancet1998，，9131： | 2 |
| 7 | Bleeding and thrombosis in myeloproliferative disorders: mechanisms and treatment显示文摘 | Raffaele Landolfi Bianca Rocca Carlo Patrono | 1995 | Critical Reviews in Oncology and Hematology1995，，3： | 1 |
| 8 | NSAID enteropathy: could probiotics prevent it?显示文摘 | Massimo Montalto Antonella Gallo Antonio Gasbarrini Raffaele Landolfi | 2013 | Journal of Gastroenterology2013，，6： | 1 |
| 9 | Early prediction of response to Sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound显示文摘 | Zocco Maria Assunta Garcovich Matteo Lupascu Andrea Di Stasio Enrico Roccarina Davide Annicchiarico Brigida Elenora Riccardi Laura Ainora Maria Elena Ponziani Francesca Caracciolo Gianluigi Rapaccini Gian Lodovico Landolfi Raffaele Siciliano Massimo Pompi | 2013 | Journal of Hepatology2013，，： | 1 |
| 10 | Lcukocytosis as an independent risk factor for thrombosis in polycythemia vera显示文摘 | Landolfi Raffaele Di Gennaro Leonardo Barbui Tiziano | 2003 | Blood 20032003，1，： | 1 |
| 11 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 1 |
| 12 | Image-Enhanced Endoscopy with I-scan Technology for the Evaluation of Duodenal Villous Patterns显示文摘 | Giovanni Cammarota Gianluca Ianiro Lucia Sparano Rossella La Mura Riccardo Ricci Luigi M. Larocca Raffaele Landolfi Antonio Gasbarrini | 2013 | Digestive Diseases and Sciences2013，，5： | 1 |
| 13 | Image-Enhanced Endoscopy with I-scan Technology for the Evaluation of Duodenal Villous Patterns显示文摘 | Giovanni Cammarota Gianluca Ianiro Lucia Sparano Rossella La Mura Riccardo Ricci Luigi M. Larocca Raffaele Landolfi Antonio Gasbarrini | 2013 | Digestive Diseases and Sciences2013，，5： | 1 |
| 14 | Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori显示文摘 | Antonio Gasbarrini Francesco Franceschi Raffaele Tartaglione Raffaele Landolfi Paolo Pola Giovanni Gasbarrini | 1998 | 1998 (9131)1998，，9131： | 1 |
| 15 | Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin显示文摘 | Rossella Cianci Simona Frosali Danilo Pagliari Paola Cesaro Lucio Petruzziello Fabio Casciano Raffaele Landolfi Guido Costamagna Franco Pandolfi Anis Larbi | 2014 | Journal of Immunology Research2014，，： | 1 |
| 16 | Leukocytosis as an independent risk factor for thrombosisin polycythemia vera显示文摘 | Landolfi Raffaele Di Gennaro | 2003 | Blood2003，108，111： | 1 |
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