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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Continuous quality and shelf life monitoring of retail-packed fresh cod loins in comparison with conventional methods显示文摘 | Nga T.T. Mai María Gudjónsdóttir Hélène L. Lauzon Kolbrún Sveinsdóttir Emilía Martinsdóttir Hubert Audorff Werner Reichstein Dietrich Haarer Sigurdur G. Bogason Sigurjón Arason | 2010 | Food Control2010，，6： | 2 |
| 3 | Paraesophageal hernia and iron deficiency anemia:Mechanisms,diagnostics and therapy显示文摘There is ample clinical evidence suggesting that the presence of large axial or paraesophageal hernias may lead to iron deficiency anemia.So-called Cameron lesions,as well as other small mucosa erosions,in the sliding area of these diaphragmatic hernias lead to invisible chronic blood loss and consequently to iron depletion.While the spectrum of symptoms in these patients is large,anemia is often not the only indication and typically not the primary indication for surgical correction of diaphragmatic hernias.Drug treatment with proton pump inhibitors and iron substitution can alleviate anemia,but this is not always successful.To exclude other possible bleeding sources in the gastrointestinal tract,a comprehensive diagnostic program is necessary and reviewed in this manuscript.Additionally,we discuss controversies in the surgical management of paraesophageal hernias. | Christoph G Dietrich Dolores Hübner Joachim W Heise | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 2 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 6 | Applications and potential of ultrasonics in food processing显示文摘 | Dietrich K Marco Z Volker H | 2004 | Trends in Food Science & Technology2004，15，5： | 1 |
| 7 | Death don't have no mercy: Cell death programs in plant-microbe interactions 显示文摘 | Dangl J L Dietrich R A Richberg M H | 1996 | Plant Cell1996，8，： | 1 |
| 8 | Multilocus haplotype analyses reveal amociatlon between 5 novel IL-15 polymorphisms and asthms显示文摘 | Kurz T Strauch K Dietrich H | 2004 | J Allergy Clin Immunol2004，113，5： | 1 |
| 9 | Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice显示文摘 | Mayr U Mayr M Li CH Wernig F Dietrich H Hu Y | 2002 | Circ Res2002，90，2： | 1 |
| 10 | Keys to the families of Cicadomorpha andsubfamilies and tribes of Cicadellidae(Hemiptera :Auchenorrhyncha)显示文摘 | Dietrich C H | 2005 | Florida Entomologist2005，88，4： | 1 |
| 11 | Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Duspl (-/-) mice: critical role of IL-6 显示文摘 | Rodriguez N Dietrich H Mossbrugger I | 2010 | J Leukoc Biol2010，88，3： | 1 |
| 12 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 13 | Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria显示文摘 | Dietrich N Rohde M Geffers R Kroger A Hauser H Weiss S | 2010 | Pro Natl Acad Sci USA2010，107，19： | 1 |
| 14 | Phylogeny of the Grassland Leafhopper Genus Flexamia( Homoptera: Cicadellidae)hased on Mitochondrial DNA Sequences显示文摘 | DIETRICH C H WHITCOMB R F BLACK W C | 1997 | Mol Phylogenetic Evol1997，8，2： | 1 |
| 15 | Hemostatic activation during cardiopulmonary bypass with different aprotinin dosages in pediatric patients having cardiac operations显示文摘 | Dietrich W Mossinger H Spannayl M | 1993 | J Thorac Cardiovasc Surg1993，105，： | 1 |
| 16 | The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels :functional characterization and physiological relevanee显示文摘 | Dietrich A Kalwa H Rost B R | 2005 | Pflugers Arch2005，451，1： | 1 |
| 17 | Systemic hypothermia for the treatment of acute cervical spinal cord injury in sports显示文摘 | Dietrich WD Cappuccino A Cappuccino H | | 0，，： | 1 |
| 18 | Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells 显示文摘 | Dietrich A Chubanov V Kalwa H | 2006 | Pharmacol Ther2006，112，3： | 1 |
| 19 | A genetic map of the mouse suitable for typing intraspecific crosses显示文摘 | Dietrich W Katz H Lincoln S E | 1992 | Genetics1992，131，2： | 1 |
| 20 | Mouse model of transplant arteriosclerosis: role of intercellular ad- hesion molecule-1 显示文摘 | DIETRICH H HU Y ZOU Y | 2000 | Arterioscler Thromb Vase Bi- ol2000，20，： | 1 |
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