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| 1 | 中国基层医疗二型糖尿病人中阳痿的普遍性,相互关联,患者态度和寻求治疗的行为显示文摘本研究探讨在基层医疗二型糖尿病人中,阳痿的普遍性、相互关联、患者态度和寻求治疗的行为。我们将一份结构性匿名自填问卷发放到十所普通科门诊诊所进行横断性调查。在603位参与者(91%回应率)中,以国际勃起功能指数(iief)作定义之阳痿的普遍性为79.1%。多数参与者患轻度阳痿(28.9%),随后为轻至中度阳痿(27.9%)、中度阳痿(13.4%)及严重阳痿(9%)。接近55%的阳痿患者并不自觉患有此症。少于10%的患者曾寻求医生治疗,76.1%的参与者表示若被确诊为阳痿,会期望得到医生治理。他们认为最重要的医生治理是临床评估(41.7%),其次是治理潜在因素(37.8%)、转介专科医生(27.5%)、教育(23.9%)、处方磷酸二酯酶5型抑制剂(16.9%),及转介辅导服务(6.7%)。与诊断阳痿最密切关联的因素是自觉患有阳痿(OR=90.49(20.00—409.48,P〈0.001))、以及较年长的组别(OR=1.043(1.011-1.076,P=0.008))。总体而言,阳痿在二型糖尿病人中非常普遍。其中大部分病人如患上阳痿都希望得到医生救治,但只有少数会真正提出此要求。建议医护人员使用结构性问卷筛选二型糖尿病人中的阳痿患者,有助于找出未被诊断的阳痿个案。 | Wai Hon Lo Sau Nga Fu Carlos King Ho Wong Ee San Chen | 2014 | Asian Journal of Andrology2014，16，5： | 8 |
| 2 | 皮质类固醇治疗外伤性视神经病变的四天关键时期显示文摘目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效。
方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料。1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量。记录从损伤开始到治疗开始的时间。视力变化是本研究结果的主要功能评价指标。在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA)。
结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例。引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%)。所有患者都表现有相对传入性瞳孔障碍。在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12)。在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步。
结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用。静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果。但还需要有更多的研究来为我们提供有明显统计学意义的数据。 | Soon Lek Yap Angeline Diong Ching Nga Nadir Ali Mohamed Ali Visvaraja Subrayan | 2008 | 国际眼科杂志2008，8，3： | 6 |
| 3 | Mechanism of Japanese encephalitis virus genotypes replacement based on human,porcine and mosquito-originated cell lines model显示文摘Objective:To examine the multiplication efficiency Japanese encephalitis virus(JEV)genotype Ⅰ(G Ⅰ) and genotype Ⅲ(GⅢ) of different cell lines which originated from human,porcine,mosquitoes in order to prove mechanism of JEV G Ⅰ replacement JEV GⅢ since it emerging in nature recent decades.Methods:The mixture of Gi and GⅢ JEV isolates was inoculated on human rhabdomyosarcoma(RD).pig kidney epithelial(PS) and Aedes albopictus C6/36 clone(C6/36) which originated from human,porcine and mosquitoes,respectively.Plaque assays were performed to calculate virus titer and real-time RT-PCR with GⅠand GⅢspecific primer sets to quantify the number of GⅠ and GUI RNA copies.Results:The highest virus titer reached at the 3rd day of post infection when G Ⅰand GⅢ mixture was inoculated on RD and PS and that of C636 was at the 4^(th)day.JEVs were amplified and maintained by C6/36 cells after 10 passages whereas that by RD and PS only limited within 8 and 6 passages,respectively.GⅠ strain amplified and maintained more efficiently on C6/36 and PS but not RD.whereas GⅢ strain amplified and maintained more efficiently on RD.Conclusions:There is a correlation between the multiplication efficiency of GⅠ and GⅢ JEV strains when these two genotype strains co-infected on different cell lines with the predominance of GⅠstrains in C6/36 and PS and the limited detection of G 1 strains in RD cells proving a possible mechanism of shift JEV genotypes in nature recent decades since GⅠ emerging. | Loan Phuong Do Trang Minh Bui Nga Thi Phan | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 5 |
| 4 | Progression from impaired fasting glucose to type 2 diabetes mellitus among C hinese subjects with and without hypertension in a primary care setting 在中国初级保健机构中合并以及不合并高血压的受试者从空腹血糖受损进展到2型糖尿病的调查显示文摘 | Sau Nga Fu Wan Luk Carlos King Ho Wong Kwok Leung Cheung | 2014 | Journal of Diabetes2014，，5： | 5 |
| 5 | Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls显示文摘Acetaminophen(APAP)is a widely used analgesic and antipyretic drug,which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses.The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology.As a result,this clinically relevant model is frequently used to study mechanisms of drug-induced liver injury and even more so to test potential therapeutic interventions.However,the complexity of the model requires a thorough understanding of the pathophysiology to obtain valid results and mechanistic information that is translatable to the clinic.However,many studies using this model are flawed,which jeopardizes the scientific and clinical relevance.The purpose of this review is to provide a framework of the model where mechanistically sound and clinically relevant data can be obtained.The discussion provides insight into the injury mechanisms and how to study it including the critical roles of drug metabolism,mitochondrial dysfunction,necrotic cell death,autophagy and the sterile inflammatory response.In addition,the most frequently made mistakes when using this model are discussed.Thus,considering these recommendations when studying APAP hepatotoxicity will facilitate the discovery of more clinically relevant interventions. | Hartmut Jaeschke Olamide B.Adelusi Jephte Y.Akakpo Nga T.Nguyen Giselle Sanchez-Guerrero David S.Umbaugh Wen-Xing Ding Anup Ramachandran | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 3 |
| 6 | Review of allergic contact dermatitis: Scratching the surface显示文摘Contact dermatitis-including allergic contact dermatitis(ACD)-n and results in over four million lost work days per year in the United States alone. ACD is a classic example of a type IV delayed hypersensitivity reaction, and represents a significant burden on the health system, economy, and patient quality of life. Thorough history taking, clinical examination, histologic evaluation, and patch testing are keys to diagnosing contact dermatitis. Patch testing, especially with comprehensive and customized panels based on the patient's exposure history, is particularly useful in identifying potential allergens inthe case of allergic contact dermatitis. ACD management requires a combination of direct medical intervention, patient education, and appropriate environmental modification to prevent exposure to offending allergens in the home or workplace. Continuing advances in the study of ACD has led to an increased understanding of the disease processes, new methods for diagnosis, and improved management. This article reviews ACD-aiming to connect recent investigational data with the current clinical understanding of disease pathophysiology, diagnostic techniques, and management strategies. | Gil S Weintraub Isabella Nga Lai Christina N Kim | 2015 | World Journal of Dermatology2015，4，2： | 3 |
| 7 | Geochemical constraints on the origin and tectonic setting of the serpentinized peridotites from the Paleoproterozoic Nyong series,Eseka area,SW Cameroon显示文摘Serpentinized rocks closely associated with Paleoproterozoic eclogitic metabasites were recently discovered at Eseka area in the northwestern edge of the Congo craton in southern Cameroon.Here,we present new field data,petrography,and first comprehensible wholerock geochemistry data and discuss the protolith and tectonic significance of these serpentinites in the region.The studied rock samples are characterized by pseudomorphic textures,including mesh microstructure formed by serpentine intergrowths with cores of olivine,bastites after pyroxene.Antigorite constitutes almost the whole bulk of the rocks and is associated(to the less amount)with tremolite,talc,spinel,and magnetite.Whole-rock chemistry of the Eseka serpentinites led to the distinction of two types.Type 1 has high MgO(>40 wt%)content and high Mg#values(88.80)whereas Type 2 serpentinite samples display relatively low MgO concentration and Mg#values(<40 and 82.88 wt%,respectively).Both types have low Al/Si and high Mg/Si ratios than the primitive mantle,reflecting a refractory abyssal mantle peridotite protolith.Partial melting modeling indicates that these rocks were derived from melting of spinel peridotite before serpentinization.Bulk rock high-Ti content is similar to the values of subducted serpentinites(>50 ppm).This similarity,associated with the high Cr contents,spinel-peridotite protolith compositions and Mg/Si and Al/Si ratios imply that the studied serpentinites were formed in a subductionrelated environment.The U-shaped chondrite normalizedREE patterns of serpentinized peridotites,coupled with similar enrichments in LREE and HFSE,suggest the refertilized nature due to melt/rock interaction prior to serpentinization.Based on the results,we suggest that the Eseka serpentinized peridotites are mantle residues that suffered a high degree of partial melting in a subductionrelated environment,especially in Supra Subduction Zone setting.These new findings suggest that the Nyong series in Cameroon represents an uncontested Paleoproterozoic suture zone between the Congo craton and the Sao Francisco craton in Brazil. | Philomene Nga Essomba Tsoungui Sylvestre Ganno Evine Laure Tanko Njiosseu Jean Lavenir Ndema Mbongue Brice Kamguia Woguia Landry Soh Tamehe Jonas Didero Takodjou Wambo Jean Paul Nzenti | 2020 | Acta Geochimica2020，39，3： | 3 |
| 8 | Comparison of surgical outcome of trabeculectomy and phacotrabeculectomy in Chinese glaucoma patients显示文摘Our study retrospectively reviewed the surgical outcomes up to 3 mo of 38 consecutive Chinese glaucoma patients who underwent trabeculectomy(n=18) or phacotrabeculectomy(n=20).Baseline age,visual acuity,and intraocular pressure were comparable.Intraocular pressure from post-operative 1 d to 3 mo were similar between 2 groups.Complete success was achieved in 65% of phacotrabeculectomy,and 66.7% of trabeculectomy cases;while failure occurred in 16.7% of phacotrabeculectomy,and 10% of trabeculectomy cases at 3 mo.Phacotrabeculectomy group consistently showed better improvement in visual acuity.Diffuse blebs occurred in 65% of phacotrabeculectomy and 83% of trabeculectomy eyes;and flat blebs in 35% of phacotrabeculectomy,but none after trabeculectomy.There was more hypotony(5% vs 0) after phacotrabeculectomy.To conclude,phacotrabeculectomy and trabeculectomy demonstrated comparable intraocular pressure control up to 3 mo post-operatively.However,phacotrabeculectomy patients had better visual acuity improvement.Nonetheless,more diffuse bleb and less hypotony were present following trabeculectomy. | Bonnie Nga Kwan Choy | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 2 |
| 9 | Modeling and predicting dengue fever cases in key regions of the Philippines using remote sensing data显示文摘Objective: To correlate climatic and environmental factors such as land surface temperature, rainfall, humidity and normalized difference vegetation index with the incidence of dengue to develop prediction models for the Philippines using remote-sensing data.Methods: Timeseries analysis was performed using dengue cases in four regions of the Philippines and monthly climatic variables extracted from Global Satellite Mapping of Precipitation for rainfall, and MODIS for the land surface temperature and normalized difference vegetation index from 2008-2015.Consistent dataset during the period of study was utilized in Autoregressive Integrated Moving Average models to predict dengue incidence in the four regions being studied.Results: The best-fitting models were selected to characterize the relationship between dengue incidence and climate variables.The predicted cases of dengue for January to December 2015 period fitted well with the actual dengue cases of the same timeframe.It also showed significantly good linear regression with a square of correlation of 0.869 5 for the four regions combined.Conclusion: Climatic and environmental variables are positively associated with dengue incidence and suit best as predictor factors using Autoregressive Integrated Moving Average models.This finding could be a meaningful tool in developing an early warning model based on weather forecasts to deliver effective public health prevention and mitigation programs. | Maria Ruth B.Pineda-Cortel Benjie M.Clemente Pham Thi Thanh Nga | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，2： | 2 |
| 10 | Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam显示文摘Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2. | Pham Thi Kim Lien Vu Trong Duoc Laurent Gavotte Emmanuel Cornillot Phan Thi Nga Laurence Briant Roger Frutos Tran Nhu Duong | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 2 |
| 11 | Mitochondrial damage and biogenesis in acetaminophen-induced liver injury显示文摘Liver injury and acute liver failure caused by acetaminophen(APAP)overdose is the clinically most important drug toxicity in Western countries.Mechanistic investigations have revealed a central role of mitochondria in the pathophysiology.Excess formation of the reactive metabolite N-acetyl-p-benzoquinone imine(NAPQI)after an overdose leads to hepatic glutathione depletion,mitochondrial protein adducts formation and an initial oxidant stress,which triggers the activation of mitogen activated protein(MAP)kinase cascade ultimately leading to c-jun N-terminal kinase(JNK)phosphorylation.Phospho-JNK translocates to the mitochondria and amplifies the oxidative and nitrosative stress eventually causing the mitochondrial membrane permeability transition pore opening and cessation of adenosine triphosphate(ATP)synthesis.In addition,mitochondrial matrix swelling ruptures the outer membrane and releases endonucleases,which cause nuclear deoxyribonucleic acid(DNA)fragmentation.Together,the nuclear DNA damage and the extensive mitochondrial dysfunction result in necrotic cell death.However,the procell death signaling events are counteracted by adaptive responses such as autophagy and mitochondrial biogenesis.The improved mechanistic insight into the pathophysiology leads to better understanding of the mechanisms of action of the existing antidote N-acetylcysteine and justifies the clinical testing of novel therapeutics such as 4-methylpyrazole and calmangafodipir. | Hartmut Jaeschke Luqi Duan Nga T.Nguyen Anup Ramachandran | 2019 | Liver Research2019，3，3： | 2 |
| 12 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 13 | Continuous quality and shelf life monitoring of retail-packed fresh cod loins in comparison with conventional methods显示文摘 | Nga T.T. Mai María Gudjónsdóttir Hélène L. Lauzon Kolbrún Sveinsdóttir Emilía Martinsdóttir Hubert Audorff Werner Reichstein Dietrich Haarer Sigurdur G. Bogason Sigurjón Arason | 2010 | Food Control2010，，6： | 2 |
| 14 | English Private Tutoring in Macao:Perceptions of Senior Secondary Three Students显示文摘Purpose:This article examines how individual,school,and social factors shape the perceptions of students in Senior Secondary Three(SS3;in some schools called Form Six[F6])toward English private tutoring in Macao.Design/Approach/Methods:This is a comparative study of two F6 classes of an English-medium secondary school and four SS3 classes of a Chinese-medium secondary school in Macao,with a total number of 145 students.Mixed-methods approach(questionnaires and interviews)is employed in the study.Findings:The respondents’participation in English tutoring is not very intensive.They prefer to receive government-subsidized after-school tutoring taught by their schoolteachers more than feepaying English tutoring taught by tutors outside.Low level of social competition and high tertiary enrollment rates contribute to this phenomenon.Students’needs and beliefs in English learning play key roles in determining their receipt of English tutoring.Originality/Value:Teachers may need better understanding of their students’needs so as to design suitable pedagogies.Schools can consider more fully the types of tutoring that they provide for different kinds of pupils.The government-subsidized after-school tutoring could be a plausible way to reduce educational inequality. | Vivien Nga Man Chan | 2019 | ECNU Review of Education2019，2，1： | 2 |
| 15 | Biochemical Polymorphism in yellow catfish ,Mystus nemurus(C&U),from Thailand 显示文摘 | Sa- Nga Leesa- Nga | 2000 | Biochemical Genetics2000，38，3： | 1 |
| 16 | HBME - 1 and CK19 Are Highly Discriminatory in the Cytological Diagnosis of Pa- pillary Thyroid Carcinoma 显示文摘 | Nga ME Lim GS Soh CH | 2008 | Diagnostic Cytopathology2008，36，8： | 1 |
| 17 | Genome analysis of lactic acid bacteria in food fermentations and biotechnological applications显示文摘 | Been Hen Nga | 2005 | Current Opinion in Microbiology2005，8，30： | 1 |
| 18 | High speed ball nose end milling of Inconel 718显示文摘 | Nga E G Leeb D W Sharmna A R C | | 0，，01： | 1 |
| 19 | Isolation and molecular characterization of Barma virus from mosquitoes,Vietnam显示文摘 | Nabeshima T Nga PT Guillermo P | 2008 | Emerg Infect Dis2008，14，8： | 1 |
| 20 | Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia显示文摘 | Nga P T del Carmen Parquet M Cuong V D | 2004 | J Gen Virol2004，85，6： | 1 |
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