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4篇 您的检索式:作者名="DING Chaofeng"
    题名 作者 年代 出处 被引量
1A combined application of different engineering and biological techniques to remediate a heavily polluted river 显示文摘SHENG Yanqing QU Yingxuan DING Chaofeng 2013Ecological Engineering2013,57,:1
23D free vibration analysis of a functionally graded piezoelectric hollow cylinder filled with compressible fluid显示文摘Chen Weiqiu Bian Zuguang Lu Chaofeng Ding Haojiang 2004International Journal of Solid and Structures2004,41,34:1
3Plasma-tungsten interactions in experimental advanced superconducting tokamak(EAST)显示文摘Tungsten(W)is used as the armor material of the International Thermonuclear Experimental Reactor(ITER)divertor and is regarded as the potential first wall material of future fusion reactors.One of the key challenges for the successful application of W in fusion devices is effective control of W at an extremely low concentration in plasma.Understanding and control of W erosion are not only a prerequisite for W impurity control,but also vital concerns to plasma-facing component(PFC)lifetime.Since the application of ITER-like water-cooled full W divertor in EAST in 2014,great efforts were made to inves-tigate W erosion by experiment and simulation.A spectroscopic system was developed to provide a real-time measurement of W sputtering source.Both experiment and simulation results indicate that carbon(C)is the dominant impurity causing W sputtering in L-mode plasmas,which comes from the erosion of C plasma-facing material(PFM)in the lower divertor and the main chamber limiters.The mixture layer on the surface of W PFCs formed through redeposition or the wall coating can effectively suppress W erosion.Increasing the plasma density and radiation can reduce incident ion energy,thus alleviating W sputtering.In H-mode plasmas,control of edge localized mode(ELM)via resonant magnetic perturbation(RMP)proves to be capable of suppressing intra-ELM W erosion.The experiences and lessons from the EAST W divertor are beneficial to the design,manufacturing and operation of ITER and beyond.Fang Ding Guang-Nan Luo Xiahua Chen Hai Xie Rui Ding Chaofeng Sang Hongmin Mao Zhenhua Hu Jing Wu Zhen Sun Liang Wang Youwen Sun Jiansheng Hu 2019Tungsten2019,1,2:1
4Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice显示文摘Primary ciliary dyskinesia(PCD)is a congenital,motile ciliopathy with pleiotropic symptoms.Although nearly 50 causative genes have been identified,they only account for approximately 70%of definitive PCD cases.Dynein axonemal heavy chain 10(DNAH10)encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm flagella.Based on the common axoneme structure of motile cilia and sperm flagella,DNAH10 variants are likely to cause PCD.Using exome sequencing,we identified a novel DNAH10 homozygous variant(c.589C>T,p.R197W)in a patient with PCD from a consanguineous family.The patient manifested sinusitis,bronchiectasis,situs inversus,and asthenoteratozoospermia.Immunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory cilia,and transmission electron microscopy revealed strikingly disordered axoneme 9+2 architecture and inner dynein arm defects in the respiratory cilia and sperm flagella.Subsequently,animal models of Dnah10-knockin mice harboring missense variants and Dnah10-knockout mice recapitulated the phenotypes of PCD,including chronic respiratory infection,male infertility,and hydrocephalus.To the best of our knowledge,this study is the first to report DNAH10 deficiency related to PCD in human and mouse models,which suggests that DNAH10 recessive mutation is causative of PCD.Rongchun Wang Danhui Yang Chaofeng Tu Cheng Lei Shuizi Ding Ting Guo Lin Wang Ying Liu Chenyang Lu Binyi Yang Shi Ouyang Ke Gong Zhiping Tan Yun Deng Yueqiu Tan Jie Qing Hong Luo 2023Frontiers of Medicine2023,17,5:0
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