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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 3 | 查看详情显示文摘 | Dong Z H Lai X Y Halpert J E Yang N L Yi L X Zhai J Wang D Tang Z Y Jiang L | | 0，，08： | 1 |
| 4 | PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer显示文摘 | Xiang B Dong D W Shi N Q Gao W Yang Z Z Cui Y | 2013 | Biomaterials2013，34，： | 1 |
| 5 | Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors 显示文摘 | Dong W Li N Gao D | 2008 | J Vasc Surg2008，48，3： | 1 |
| 6 | Methanolysis of Triolein by Low Frequency Ultrasonic Irradiation 显示文摘 | Hanh H D Dong N T Starvarache C | 2008 | Energy Conversion and Management2008，49，： | 1 |
| 7 | Overexpression of the acidic dehydrin WCOR410 improves freezing tolerance in transgenic strawberry leaves显示文摘 | HOUDE M DALLAIRE S N'DONG D SARHAN F | 2004 | Plant Biotechnol2004，2，5： | 1 |
| 8 | Carbohydrate-specifically polyethylene glycol-modified ricin A-chain with improved therapeutic potential 显示文摘 | Yu S Y Dong H N Sun D Y | 2005 | Inter J Biochem Cell Biol2005，37，7： | 1 |
| 9 | Global Positioning System Net- work Analysis with Phase Ambiguity Resolution Applied to Crustal Deformation Studies in California显示文摘 | Dong D N Bock Y | | 0，，4： | 1 |
| 10 | Estimating regional deformation from a combination of space and terrestrial geodetic data显示文摘 | Dong D N Herring T A and King R W | 1998 | J Geod1998，，： | 1 |
| 11 | Anatomy of apparent seasonal variations from GPS derived site position time se- ries 显示文摘 | Dong D N Fang P Bock Y | 2002 | Journal of Geophysical Research2002，107，4： | 1 |
| 12 | UV-induced DNA damage initiates release of MMP-1 in human skin显示文摘 | Dong K K Damaghi N Picart S D | | 0，，12： | 1 |
| 13 | A supply chain network equilibrium model显示文摘 | N agurney A Dong J Zhang D | 2002 | Transportation Research: Part E2002，38，5： | 1 |
| 14 | Resveratrol attenuates ischemic brain damage in the delayed phase atter stroke and induces messenger RNA and protein express for angiogenic factors 显示文摘 | Dong W Li N Gao D | 2008 | J Vasc Surg2008，48，3： | 1 |
| 15 | Human infection with a novel avian-origin influenza A(H7N9)virus显示文摘 | Gao R Cao B Hu Y Feng Z Wang D Chen J Jie Z Qiu H Xu K Xu X Lu H Zhu W Gao Z Xiang N Shen Y He Z Gu Y Zhang Z Yang Y Zhao X Zhou L Li X Zou S Zhang Y Li X Yang L Guo J Dong J Li Q Dong L Zhu Y Bai T Wang S Hao P Yang W Zhang Y Han J Yu H Li D Gao GF Wu G Wang Y Yuan Z Shu Y | 2013 | N Engl J Med2013，368，： | 1 |
| 16 | Thermally switchable and discretely tunable comb filter with a linearly chirped fiber Bragg grating显示文摘 | Ngo N Q Liu D Tjin S C Dong X Shum P | | 0，，22： | 1 |
| 17 | Experimental studies on the performance of slipper bearings within axial-piston pumps 显示文摘 | MARRING N D WRAY C L DONG Z | 2004 | Journal of Tribology2004，，116： | 1 |
| 18 | Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors 显示文摘 | Dong W Li N Gao D | 2008 | J Vase Surg2008，48，3： | 1 |
| 19 | Simultane-ous determination of17sulfonamide residues in porcine meat,kidney and liver by solid-phase ex-traction and liquid chromatography-tandem mass spectrometry显示文摘 | SHAO B DONG D WU Y N | 2005 | Anal Chim Acta2005，546，： | 1 |
| 20 | Realization of narrow kand filtering ofthe polar montion data with multi-stage filter translated显示文摘 | Zheng D W Dong D N | 1986 | Acta Astrom Sin1986，27，： | 1 |
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