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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Three-dimensional structural changes in living hippocampal neurons imaged using magnetic AC mode atomic force microscopy.显示文摘 | Yunxu S Danying L Yanfang R Dong H Wanyun M | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 3 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 4 | Electrochemical investigation of DNA adsorbed on conducting polymer modified electrode显示文摘 | Li L Wang M Dong S | 1997 | Analytical Sciences1997，13，： | 1 |
| 5 | Providing Distributed Certificate Authority Service in Cluster-based Mobile Ad Hoc Networks显示文摘 | Dong Y Sui Ai-fen Yiu S M | 2007 | Computer Communications2007，30，1112： | 1 |
| 6 | Sesquiterpenoids fromIncarvillea arguta: absolute configuration and biologicalevaluation 显示文摘 | Yan Y M Wu G S Dong X P | 2012 | J Nat Prod2012，75，6： | 1 |
| 7 | Antioxidant and biochemical properties of protein hydrolysates prepared from silver carp(Hypophthalmichthys molitrix) 显示文摘 | Dong S Y Zeng M Y Wang D F | 2008 | Food Chemistry2008，107，4： | 1 |
| 8 | Overvalued equity and financing decisions 显示文摘 | DONG M HIRSHLEIFER D TEOH S H | 2012 | Review of Financial Studies2012，25，12： | 1 |
| 9 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 10 | Nonlocal Image Restoration with Bilateral Variance Estimation: a Low-rank Approach 显示文摘 | DONG W S SHI G M LI X | 2013 | IEEE Transactions on Image Processing2013，22，2： | 1 |
| 11 | Apparent protein digestibility and mineral availabilities in various feed ingredients for salmonid feeds显示文摘 | Sugiura S H Dong F M Rathbone C K | 1998 | Aquaculture1998，159，： | 1 |
| 12 | Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling显示文摘 | Dong C H Rivarola M Resnick J S | 2008 | Plant J2008，53，2： | 1 |
| 13 | Molecular characterization of two pheromone binding proteins and quantitative analysis of their expression in the beet armyworm, Spodoptera exigua Hubner显示文摘 | Xiu W M Dong S L | 2007 | J Chem Ecol2007，33，： | 1 |
| 14 | Isolation and inheritance of microsatllite markers in the common carp Cyprinus carpio 显示文摘 | Aliah R S Takagi M Dong S | 1999 | Fish Sci1999，65，2： | 1 |
| 15 | The genetic diversity of annual wild soybeans grown in China显示文摘 | Dong Y S Zhuang B C Zhao L M | 2001 | Theor Appl Genet2001，103，1： | 1 |
| 16 | Mechanical Properties and Microstrucmres of C/SiC-ZrC Composites using T700SC Carbon Fibers as Reinforcements显示文摘 | Wang Z Dong S M Ding Y S | 2011 | Ceram Int2011，37，： | 1 |
| 17 | A comparision of CO2minimum miscibility pressure determinations for Weyburn crude oil显示文摘 | Dong M Huang S Dyer S B | 2001 | J Pet Sci Eng2001，，31： | 1 |
| 18 | 查看详情显示文摘 | Dong W Y Sun Y J Lee C W Hua W M Lu X C Shi Y F Zhang S C Chen J M Zhao D Y | | 0，，： | 1 |
| 19 | Influence of degree of molar etherification on critical liquid crystal behavior of hydroxypropyl chitosan显示文摘 | Dong Y M Wu Y S Wang J W | 2001 | European Polymer Journal2001，37，8： | 1 |
| 20 | Isoform-specific contributions of alphaaetinin to glioma cell mechanobiology显示文摘 | Sen S Dong M Kumar S | 2009 | PLoS one2009，4，12： | 1 |
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