| 1 | Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota显示文摘Background:Salmonella pullorum is one of the most harmful pathogens to avian species.Magnolol and honokiol,natural compounds extracted from Magnolia officinalis,exerts anti-inflammatory,anti-oxidant and antibacterial activities.This study was conducted to evaluate the effects of dietary supplemental magnolol and honokiol in broilers infected with S.pullorum.A total of 360 one-day-old broilers were selected and randomly divided into four groups with six replicates:the negative control group(CTL),S.pullorum-infected group(SP),and the S.pulloruminfected group supplemented with 300 mg/kg honokiol(SPH)or magnolol(SPM).Results:The results showed that challenging with S.pullorum impaired growth performance in broilers,as indicated by the observed decreases in body weight(P<0.05)and average daily gains(P<0.05),along with increased spleen(P<0.01)and bursa of Fabricus weights(P<0.05),serum globulin contents,and the decreased intestine villus height and villus/crypt ratios(P<0.05).Notably,supplemental magnolol and honokiol attenuated these adverse changes,and the effects of magnolol were better than those of honokiol.Therefore,we performed RNA-Seq in ileum tissues and 16S rRNA gene sequencing of ileum bacteria.Our analysis revealed that magnolol increased the α-diversity(observed species,Chao1,ACE,and PD whole tree)and β-diversity of the ileum bacteria(P<0.05).In addition,magnolol supplementation increased the abundance of Lactobacillus(P<0.01)and decreased unidentified Cyanobacteria(P<0.05)both at d 14 and d 21.Further study confirmed that differentially expressed genes induced by magnolol and honokiol supplementation enriched in cytokine-cytokine receptor interactions,in the intestinal immune network for IgA production,and in the cell adhesion molecule pathways.Conclusions:Supplemental magnolol and honokiol alleviated S.pullorum-induced impairments in growth performance,and the effect of magnolol was better than that of honokiol,which could be partially due to magnolol’s ability to improve the intestinal microbial and mucosal barrier. | Fang Chen Hao Zhang Encun Du Qiwen Fan Na Zhao Feng Jin Wei Zhang Wanzheng Guo Shaowen Huang Jintao Wei | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 9 |
| 2 | Numerical Study of Dual Sweeping Jet Actuators for Corner Separation Control in Compressor Cascade显示文摘Unsteady behaviors are important issues in flow control of turbomachinery.Pulsed excitation or suction is widely investigated in compressor cascades.This paper presents a discussion on the unsteady flow control realized by dual sweeping jet actuator(SJA)located on the blade suction surface.The unsteady numerical simulations were utilized to study the effect of applying dual SJAs on controlling the corner separation.With the numerical results,the following conclusions could be drawn with current compressor cascade.A maximum total pressure loss coefficient reduction of 6.8%was obtained.The analysis of the flow field pointed out that the regulation mechanisms of the corner separation were different with each SJA.The SJA ahead achieved an interruption of the suction side boundary layer development and the rear SJA enhanced the interaction and entrainment between the excitation stream and the secondary flows.Meanwhile,the different unsteadiness structures of the flow field frequency spectrum compared with single SJA cases were identified.The first peak frequency corresponded to the difference of the two SJAs and the rest frequencies could be regulated to a base frequency and its harmonic frequencies. | MENG Qinghe DU Xin CHEN Shaowen WANG Songtao | 2021 | Journal of Thermal Science2021，30，1： | 2 |
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