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| 1 | Research progress of disinfection and disinfection by-products in China显示文摘Disinfection is an indispensable water treatment process for killing harmful pathogens and protecting human health. However, the disinfection has caused significant public concern due to the formation of toxic disinfection by-products(DBPs). Lots of studies on disinfection and DBPs have been performed in the world since 1974. Although related studies in China started in1980 s, a great progress has been achieved during the last three decades. Therefore, this review summarized the main achievements on disinfection and DPBs studies in China, which included:(1) the occurrence of DBPs in water of China,(2) the identification and detection methods of DBPs,(3) the formation mechanisms of DBPs during disinfection process,(4) the toxicological effects and epidemiological surveys of DBPs,(5) the control and management countermeasures of DBPs in water disinfection, and(6) the challenges and chances of DBPs studies in future. It is expected that this review would provide useful information and reference for optimizing disinfection process, reducing DBPs formation and protecting human health. | Xuefeng Sun Miao Chen Dongbin Wei Yuguo Du | 2019 | Journal of Environmental Sciences2019，31，7： | 18 |
| 2 | Climatic trends of different intensity heavy precipitation events concentration in China显示文摘Based on 740 stations of daily precipitation datasets in China, the precipitation- concentration degree (PCD)and precipitation-concentration period (PCP)ofdifferentintensity durative precipitation eventswere calculated to analyze theirstatisticalcharacteristics,mainly including spatial and temporaldistributions,variations and climatic trends ofthe two parameters ofthe durative heavy precipitation events in China.Itis proved thatthese two parameters ofheavy rainfallcan display the temporalinhomogeneity in the precipitation field.And itis also found thatthere is a good positive relationship between the precipitation-concentration degree and annualrainfallamountin the Eastern and CentralChina.Thismethod can beapplied in flood assessmentand climatechangefields. | XIE Zhiqing DU Yin JIANG Aijun DING Yuguo | 2005 | Journal of Geographical Sciences2005，15，4： | 15 |
| 3 | A biological safety evaluation on reclaimed water reused as scenic water using a bioassay battery显示文摘An assessment method based on three toxicity tests (algae growth inhibition,daphnia immobilization and larval fish toxicity) was used to screen the biological safety of reclaimed water which was reused as sole replenishment for scenic water system in a park (SOF Park) in northern China.A total of 24 water samples were collected from six sites of water system in the SOF Park in four different seasons.The results indicated that:(1) the reclaimed water directly discharged from a reclamation treatment plant near the SOF Park as influent of park had relatively low biological safety (all samples were ranked as C or D);(2) the biological safety of reclaimed water was improved greatly with the ecological reclamation treatment processes composing of artificial wetland system and followed oxidation pond system;(3) the biological safety of reclaimed water in the main lake of SOF Park kept at a health status during different seasons (all samples were ranked as A);(4) there was some certain correlation (R 2=0.5737) between the sum of toxicity scores and dissolved organic carbon for the studied water samples.It was concluded that the assessment method was reliable to screen the safety of reclaimed water reused as scenic water,and the reclaimed water with further ecological purification processes such as artificial wetland and oxidation pond system can be safely reused as scenic water in park. | Dongbin Wei Zhuowei Tan Yuguo Du | 2011 | Journal of Environmental Sciences2011，23，10： | 9 |
| 4 | A toxicity-based method for evaluating safety of reclaimed water for environmental reuses显示文摘A large quantity of toxic chemical pollutants possibly remains in reclaimed water due to the limited removal efficiency in traditional reclamation processes. It is not enough to guarantee the safety of reclaimed water using conventional water quality criteria. An integrated assessment method based on toxicity test is necessary to vividly depict the safety of reclaimed water for reuse. A toxicity test battery consisting of lethality, genotoxicity and endocrine disrupting effect was designed to screen the multiple biological effects of residual toxic chemicals in reclaimed water. The toxicity results of reclaimed water were converted into the equivalent concentrations of the corresponding positive reference substances(EQC). Simultaneously, the predicted no-effect concentration(PNEC) of each positive reference substance was obtained by analyzing the species sensitivity distribution(SSD) of toxicity data. An index 'toxicity score' was proposed and valued as 1, 2, 3, or 4 depending on the ratio of the corresponding EQC to PNEC. For vividly ranking the safety of reclaimed water, an integrated assessment index 'toxicity rank' was proposed, which was classified into A, B, C, or D rank with A being the safest. The proposed method was proved to be effective in evaluating reclaimed water samples in case studies. | Jianying Xu Chuntao Zhao Dongbin Wei Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，10： | 9 |
| 5 | Inflammatory response and insulin signaling alteration induced by PCB77显示文摘A specific mechanism whereby inflammation may contribute to cardiovascular diseases(CVD),insulin resistance(IR) and type II diabetes is the induction of endothelial dysfunction placing the vascular endothelium in a key unifying position for the shared pathogenesis of these diseases.However,the mechanisms by which PCBs induce endothelial cell dysfunction are not clearly understood.In the present study,we used human umbilical vascular endothelial cells(HUVEC) as model,and inflammatory response and insulin signaling alteration induced by PCBs were examined.Results showed that PCB77 induced the expression of proinflammatory cytokines including IL-6 and TNFα and induced U937 adhesion to HUVEC cells consistent with increased NFκB transcription activity.On the other hand,PCB77 blocked insulin-activated Akt signaling pathway,which was restored by pretreatment with TNFα neutralization antibody.In conclusion,PCB77 showed the potential to induce the expression of proinflammatory cytokines including IL-6,which has been shown to be powerful independent risk predictor of CVD.And PCB77 was observed to alter insulin-activated Akt signaling by TNFα secretion for the first time. | Jing Wang Xiaowen Lv Yuguo Du | 2010 | Journal of Environmental Sciences2010，22，7： | 8 |
| 6 | Toxicity-based assessment of the treatment performance of wastewater treatment and reclamation processes显示文摘The reclamation and reuse of wastewater is one of the possible ways to relieve the serious fresh water resource crisis in China. Efficient reclamation treatment technologies ensure the safe reuse of reclaimed water. In order to screen out and evaluate technologies appropriate for reclamation treatment, a great deal of efforts have been brought to bear. In the present study, a toxicity-based method including a Photobacterium phosphoreum test for acute toxicity and SOS/umu test for genotoxicity, accompanied by the traditional physicochemical parameters DOC (dissolved organic carbon) and UV 254 (absorbance at 254 nm), was used to measure the treatment performance of different reclamation processes, including the anaerobic-anoxic-oxic biological process (A2O) and subsequent physical/chemical reclamation processes (ultrafiltration, ozonation, chlorination). It was found that for the secondary effluent after the A2O process, both the toxicity and physicochemical indices had greatly decreased compared with those of the influent. However, chemical reclamation processes such as ozonation and chlorination could possibly raise toxicity levels again. Fortunately, the toxicity elevation could be avoided by optimizing the ozone dosage and using activated carbon after ozonation. It was noted that by increasing the ozone dosage to 10 mg/L and employing activated carbon with more than 10 min hydraulic retention time, toxicity elevation was controlled. Furthermore, it was shown that pre-ozonation before activated carbon and chlorination played an important role in removing organic compounds and reducing the toxicity formation potential. The toxicity test could serve as a valuable tool to evaluate the performance of reclamation processes. | Dongbin Wei Zhuowei Tan Yuguo Du | 2012 | Journal of Environmental Sciences2012，24，6： | 7 |
| 7 | Predicted no-effect concentrations for mercury species and ecological risk assessment for mercury pollution in aquatic environment显示文摘Mercury(Hg) exists in different chemical forms presenting varied toxic potentials. It is necessary to explore an ecological risk assessment method for different mercury species in aquatic environment. The predicted no-effect concentrations(PNECs) for Hg(Ⅱ) and methyl mercury(Me Hg) in the aqueous phase, calculated using the species sensitivity distribution method and the assessment factor method, were 0.39 and 6.5 × 10-3μg/L, respectively. The partition theory of Hg between sediment and aqueous phases was considered, along with PNECs for the aqueous phase to conduct an ecological risk assessment for Hg in the sediment phase. Two case studies, one in China and one in the Western Black Sea, were conducted using these PNECs. The toxicity of mercury is heavily dependent on their forms,and their potential ecological risk should be respectively evaluated on the basis of mercury species. | Meng Du Dongbin Wei Zhuowei Tan Aiwu Lin Yuguo Du | 2015 | Journal of Environmental Sciences2015，27，2： | 6 |
| 8 | Acute toxicity formation potential of benzophenone-type UV filters in chlorination disinfection process显示文摘Benzophenones(BPs) are a class of widely used UV filters, which have been frequently detected within multiple environmental matrices. Disinfection is a necessary process in water treatment processes. The transformation behaviors and toxicity changes of 14 BP-type UV filters during chlorination disinfection treatment were investigated in this study. A new index, the acute toxicity formation potential, was proposed to evaluate the toxicity changes and potential risks of BP-type UV filters during chlorination treatment. It was found that 13 of 14 BP-type UV filters exhibited toxicity decreases in the chlorination disinfection process, more or less, while one showed a toxicity increase. The toxicity changes were dependent on substitution effects, such that 2,4-di-hydroxylated or 3-hydroxylated BPs exhibited significant toxicity decreases after chlorination treatment due to the ready cleavage of the aromatic ring. Importantly, the acute toxicity changes could be duplicated in an ambient water matrix. | Qi Liu Zhenbin Chen Dongbin Wei Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，2： | 5 |
| 9 | The potential risk assessment for different arsenic species in the aquatic environment显示文摘The different toxicity characteristics of arsenic species result in discrepant ecological risk.The predicted no-effect concentrations(PNECs) 43.65, 250.18, and 2.00 × 103μg/L were calculated for As(III), As(V), and dimethylarsinic acid in aqueous phase, respectively. With these PNECs, the ecological risk from arsenic species in Pearl River Delta in China and Kwabrafo stream in Ghana was evaluated. It was found that the risk from As(III) and As(V)in the samples from Pearl River Delta was low, while much high in Kwabrafo stream. This study implies that ecological risk of arsenic should be evaluated basing on its species. | Meng Du Dongbin Wei Zhuowei Tan Aiwu Lin Yuguo Du | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 10 | Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo显示文摘Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota. | Yue Tang Qidong Ren Qing Wen Caixia Yu Xinni Xie Qing Hu Yuguo Du | 2019 | Journal of Environmental Sciences2019，31，11： | 4 |
| 11 | Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes显示文摘Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibrio fischeri assay.The minimum IC20(inhibitory concentration for 20%luminescence elimination)was obtained at the least 18.86μmol/L for the tested quinolones.A quantitative structure–activity relationship model was established to investigate the possible mechanism for the acute toxicity.The critical physicochemical descriptors,describingσandπatom electronegativity,implied that the electron transfer might occur between the quinolones and photobacterium V.fischeri.Although the quinolones exhibited limited acute toxicity to photobacterium,toxicity elevation was detected after their chlorination.Hence,chlorination disinfection treatment of quinolone-containing water should be of concerns. | Min Li Dongbin Wei Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，9： | 4 |
| 12 | Formation pathways of brominated products from benzophenone-4 chlorination in the presence of bromide ions显示文摘The brominated products,formed in chlorination treatment of benzophenone-4 in the presence of bromide ions,were identified,and the formation pathways were proposed.Under disinfection conditions,benzophenone-4 would undertake electrophilic substitution generating mono-or di-halogenated products,which would be oxidized to esters and further hydrolyzed to phenol derivatives.The generated catechol intermediate would be transformed into furan-like heterocyclic product.The product species were p H-dependent,while benzophenone-4 elimination was chlorine dose-dependent.When the chlorination treatment was performed on ambient water spiked with benzophenone-4 and bromide ions,most of brominated byproducts could be detected,and the acute toxicity significantly increased as well. | Ming Xiao Dongbin Wei Liping Li Qi Liu Huimin Zhao Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，12： | 3 |
| 13 | Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles显示文摘As well-known persistent organic pollutants(POPs), organofluorine pollutants such as perfluorooctane sulfonate(PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles,trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles(PTFEPMMA NPs) were synthesized with various fluorine contents(PTFE-PMMA-1 NPs 12.0 wt.%,PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine(F) contents and Fcontaining side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose(50 μg/m L) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species(ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials(ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. | Xue Wang Wenge Cheng Qiuyuan Yang Hongyun Niu Qian Liu Yun Liu Ming Gao Ming Xu An Xu Sijin Liu Xiaoyu Huang Yuguo Du | 2018 | Journal of Environmental Sciences2018，30，7： | 2 |
| 14 | A synthetical methodology for identifying pr ior ity pollutants in reclaimed water based on meta-analysis显示文摘Wastewater reclamation and reuse is an increasing global project,while the reclamation treatment on wastewater does not completely remove all pollutants in water.The residual pollutants in reclaimed water would cause potential risk on human health and ecosystem safety during the long-term use.It is impossible to analyze and control all pollutants one by one in practice,therefore,identification and control of priority pollutants will be efficient strategy to ensure the safe use of reclaimed water.An integrated three-step methodology for identifying priority pollutants in reclaimed water was proposed in this study.First,a comprehensive literature survey on the occurrence of pollutants in reclaimed water was conducted,and a dataset D PR for pollutants occurrence in reclaimed water was established,containing 1,113 pollutants.Second,611 chemicals that had been recommended as hazardous pollutants for various water bodies in previous literatures were summarized,and a dataset D HP for hazardous pollutants in water was obtained.Third,meta-analysis on these two datasets(D PR and D HP)was performed,a new dataset D HPR for hazardous pollutants in reclaimed water was established,including 265 candidates.Finally,59 substances out of dataset D HPR were identified as priority pollutants for reclaimed water based on their recommendation frequency.It is expected that this synthetical methodology will provide powerful support for scientific evaluating and managing water pollution and ensuring safe use of reclaimed water. | Feipeng Wang Dongbin Wei Miao Chen Shuang Peng Qiaorong Guo Xinyi Zhang Jun Liu Yuguo Du | 2022 | Journal of Environmental Sciences2022，34，2： | 2 |
| 15 | A neglected GABAergic astrocyte:Calcium dynamics and involvement in seizure activity显示文摘Gamma-aminobutyric acid(GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy are not well understood, since GABA agonists are not quite effective in treating epilepsy. Knowledge of the mechanism of action of GABA would contribute to review previously proposed anti-epileptic processes by GABA agonists. In this study based on recent experiments on GABAergic astrocytes, we developed a modified GABAergic astrocyte model, and successfully simulated a long-lasting Ca^(2+) oscillation in astrocytes after 0.5-s stimulation of GABAergic transmission. We then incorporated this GABAergic astrocyte model into a classical Ullah-Schiff seizure model and surprisingly found that this GABAergic astrocyte model functions to hinder the anti-epileptic action of GABA agonists, thereby explaining their low efficiency in previous experiments. These results also update our knowledge of the mechanism of action of GABA and the effects of astrocytes on physiological and pathological functions of the brain. | LI JiaJia XIE Yong YU YuGuo DU MengMeng WANG Rong WU Ying | 2017 | Science China(Technological Sciences)2017，60，7： | 2 |
| 16 | Acute toxicity variation of hydroxyl benzophenone UV filters during photoinduction–chlorination disinfection processes显示文摘Benzophenones(BPs), a group of widely used UV filters, exert multiple, significant toxicity effects. The 11 BPs were selected as target compounds, and the photobacterium acute toxicity test and an index for acute toxicity formation potential(ATFP) were used to evaluate the toxicity variation of BPs before and after a photoinduction–chlorination disinfection process.Orthogonal experiments were performed at different pH values and chlorine dosages. The characteristics of ATFP values for 11 BPs after a photoinduction–chlorination process can be summarized as follows:(1) The ATFPs decreased as the hydroxyl group number increased in BPs molecules.(2) For those BPs with the same hydroxyl group number, the ATFPs were higher when the hydroxyl groups were located at the 3-or 4-position than those at the 2-position; the BPs with hydroxyl groups distributed on two benzene rings had higher ATFPs than those on one ring.(3) Introducing a methoxyl group and sulfonic acid group into BP molecules increased the ATFP values.(4) The ATFPs were p H-dependent, the values of which were lowest at the neutral condition and highest at the acid condition.(5) The ATFPs increased and then decreased as the chlorine dosage increased. The results can be used as a reference to scientifically evaluate the environmental fate and potential risk of BPs in photoinduction–chlorination disinfection processes. | Qi Yu | 2017 | Journal of Environmental Sciences2017，29，4： | 2 |
| 17 | FeCl3-catalyzed α-glycosidation of glycosamine pentaacetates显示文摘 | WEI Guohua LU Xun DU Yuguo | 2008 | Carbohydr Res2008，343，18： | 1 |
| 18 | The chlorination transformation characteristics of benzophenone-4 in the presence of iodide ions显示文摘Benzophenone-type UV filters are a group of compounds widely used to protect human skin from damage of UV irradiation. Benzophenone-4(BP-4) was targeted to explore its transformation behaviors during chlorination disinfection treatment in the presence of iodide ions. With the help of ultra performance liquid phase chromatograph and high-resolution quadrupole time-of-flight mass spectrometer, totally fifteen halogenated products were identified, and five out of them were iodinated products. The transformation mechanisms of BP-4 involved electrophilic substitution generating mono-or di-halogenated products,which would be oxidized into esters and further hydrolyzed into phenolic derivatives. The desulfonation and decarboxylation were observed in chlorination system either. Obeying the transformation pathways, five iodinated products formed. The p H conditions of chlorination system determined the reaction types of transformation and corresponding species of products. The more important was that, the acute toxicity had significant increase after chlorination treatment on BP-4, especially in the presence of iodide ions. When the chlorination treatment was performed on ambient water spiked with BP-4 and iodide ions,iodinated by-products could be detected. | Fan Yang Dongbin Wei Ming Xiao Xuefeng Sun Qiaorong Guo Yi Liu Yuguo Du | 2017 | Journal of Environmental Sciences2017，29，8： | 1 |
| 19 | Troglitazone Induced Apoptosis via PPARγ Activated POX-induced ROS Formation in HT29 Cells显示文摘Objective In order to investigate the potential mechanisms in troglitazone-induced apoptosis in HT29 cells,the effects of PPARγ and POX-induced ROS were explored.Methods [3-(4,5)-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay,Annexin V and PI staining using FACS,plasmid transfection,ROS formation detected by DCFH staining,RNA interference,RT-PCR & RT-QPCR,and Western blotting analyses were employed to investigate the apoptotic effect of troglitazone and the potential role of PPARγ pathway and POX-induced ROS formation in HT29 cells.Results Troglitazone was found to inhibit the growth of HT29 cells by induction of apoptosis.During this process,mitochondria related pathways including ROS formation,POX expression and cytochrome c release increased,which were inhibited by pretreatment with GW9662,a specific antagonist of PPARγ.These results illustrated that POX upregulation and ROS formation in apoptosis induced by troglitazone was modulated in PPARγ-dependent pattern.Furthermore,the inhibition of ROS and apoptosis after POX siRNA used in troglitazone-treated HT29 cells indicated that POX be essential in the ROS formation and PPARγ-dependent apoptosis induced by troglitazone.Conclusion The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation,at least partly,via PPARγ activation. | WANG Jing LV XiaoWen SHI JiePing HU XiaoSong DU YuGuo | 2011 | Biomedical and Environmental Sciences2011，24，4： | 1 |
| 20 | Genotoxicity of quinolones: Substituents contribution and transformation products QSAR evaluation using 2D and 3D models显示文摘 | Min Li Dongbin Wei Huimin Zhao Yuguo Du | 2014 | Chemosphere2014，，： | 1 |
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