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| 1 | Inflammatory response and insulin signaling alteration induced by PCB77显示文摘A specific mechanism whereby inflammation may contribute to cardiovascular diseases(CVD),insulin resistance(IR) and type II diabetes is the induction of endothelial dysfunction placing the vascular endothelium in a key unifying position for the shared pathogenesis of these diseases.However,the mechanisms by which PCBs induce endothelial cell dysfunction are not clearly understood.In the present study,we used human umbilical vascular endothelial cells(HUVEC) as model,and inflammatory response and insulin signaling alteration induced by PCBs were examined.Results showed that PCB77 induced the expression of proinflammatory cytokines including IL-6 and TNFα and induced U937 adhesion to HUVEC cells consistent with increased NFκB transcription activity.On the other hand,PCB77 blocked insulin-activated Akt signaling pathway,which was restored by pretreatment with TNFα neutralization antibody.In conclusion,PCB77 showed the potential to induce the expression of proinflammatory cytokines including IL-6,which has been shown to be powerful independent risk predictor of CVD.And PCB77 was observed to alter insulin-activated Akt signaling by TNFα secretion for the first time. | Jing Wang Xiaowen Lv Yuguo Du | 2010 | Journal of Environmental Sciences2010，22，7： | 8 |
| 2 | Characterization of aircraft emissions and air quality impacts of an international airport显示文摘Beijing Capital International Airport(ZBAA) is the world's second busiest airport. In this study, the emissions of air pollutants from aircraft and other sources at ZBAA in 2015 were estimated using an improved method, which considered the mixing layer height calculated based on aircraft meteorological data relay(AMDAR), instead of using the height(915 m)recommended by ICAO. The yearly emissions of NO_x, CO, VOCs, SO_2, and PM_(2.5) at the airport were 8.76 × 10~3, 4.43 × 10~3, 5.43 × 10~2, 4.80 × 10~2, and 1.49 × 10~2 ton/year, respectively. The spatial–temporal distribution of aircraft emissions was systematically analyzed to understand the emission characteristics of aircraft. The results indicated that NOxwas mainly emitted during the take-off and climb phases, accounting for 20.5% and 55.5% of the total emissions. CO and HC were mainly emitted during the taxi phase, accounting for 91.6%and 92.2% of the total emissions. Because the mixing layer height was high in summer, the emissions of aircraft were at the highest level throughout the year. Based on the detailed emissions inventory, four seasons simulation using WRF-CMAQ model was performed over the domain surrounding the airport. The results indicated that the contribution to PM_(2.5) was relatively high in winter; the average impact was about 1.15 μg/m^3 within a radius of1 km around the airport. Meanwhile, the near surroundings and southwest areas of the airport are the most sensitive to PM_(2.5). | Xiaowen Yang Shuiyuan Cheng Jianlei Lang Ran Xu Zhe Lv | 2018 | Journal of Environmental Sciences2018，30，10： | 5 |
| 3 | A consensus linkage map of common carp (Cyprinus carpio L.) to compare the distribution and variation of QTLs associated with growth traits显示文摘The ability to detect and identify quantitative trait loci (QTLs) in a single population is often limited. Analyzing multiple populations in QTL analysis improves the power of detecting QTLs and provides a better understanding of their functional allelic variation and distribution. In this study, a consensus map of the common carp was constructed, based on four populations, to compare the distribution and variation of QTLs. The consensus map spans 2371.6 cM across the 42 linkage groups and comprises 257 microsatellites and 421 SNPs, with a mean marker interval of 3.7 cM/marker. Sixty-seven QTLs affecting four growth traits from the four populations were mapped to the consensus map. Only one QTL was common to three populations, and nine QTLs were detected in two populations. However, no QTL was common to all four populations. The results of the QTL comparison suggest that the QTLs are responsible for the phenotypic variability observed for these traits in a broad array of common carp germplasms. The study also reveals the different genetic performances between major and minor genes in different populations. | ZHENG XianHu KUANG YouYi LV WeiHua CAO DingChen ZHANG XiaoFeng LI Chao LU CuiYun SUN XiaoWen | 2013 | Science China(Life Sciences)2013，56，4： | 4 |
| 4 | Fractal-based weak target detection within sea clutter显示文摘The target on the sea surface is complex and difficult to detect due to the interference of backscattered returns from the sea surface illuminated by the radar pulse. Detrended fluctuation analysis(DFA) has been used successfully to extract the time-domain Hurst exponent of sea-clutter series. Since the frequency of the sea clutter mainly concentrates around Doppler center so that we consider to extract frequency-domain fractal characterization and then detect a weak target within sea clutter by using the difference of frequency-domain fractal characterization. The generalized detrended fluctuation analysis(GDFA) is more flexible than traditional DFA owing to its smoothing action for the clutters. In this paper, we apply the GDFA to evaluate the generalized Hurst exponent of sea-clutter series in the frequency domain. The difference of generalized Hurst exponents between different sea-clutter range bins would be used to determine whether the target exists. Moreover, some simulations with the real IPIX radar data have also been demonstrated in order to support this conclusion. | LI Yang LV Xiaowen LIU Kuisheng ZHAO Shangzhuo | 2014 | Acta Oceanologica Sinica2014，33，9： | 2 |
| 5 | Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro显示文摘Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB;2,4,and 8 μM).Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression,and increased neuronal survival in a dose-dependent manner.Moreover,MDHB induced brain-derived neurotrophic factor expression.These findings suggest that MDHB has a neurotrophic effect,which may be due to its ability to increase brain-derived neurotrophic factor expression. | Zheng Zhang Xing Zhou Xiaowen Zhou Xiao Xu Minjing Liao Li Yan Ruohua Lv Huanmin Luo | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 6 | Assessment of melamine contamination in crop,soil and water in China and risks of melamine accumulation in animal tissues and products显示文摘 | Yuchang Qin、Xiaowen Lv、Jun Li | 2010 | Environment International2010，36，5： | 1 |
| 7 | Troglitazone Induced Apoptosis via PPARγ Activated POX-induced ROS Formation in HT29 Cells显示文摘Objective In order to investigate the potential mechanisms in troglitazone-induced apoptosis in HT29 cells,the effects of PPARγ and POX-induced ROS were explored.Methods [3-(4,5)-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay,Annexin V and PI staining using FACS,plasmid transfection,ROS formation detected by DCFH staining,RNA interference,RT-PCR & RT-QPCR,and Western blotting analyses were employed to investigate the apoptotic effect of troglitazone and the potential role of PPARγ pathway and POX-induced ROS formation in HT29 cells.Results Troglitazone was found to inhibit the growth of HT29 cells by induction of apoptosis.During this process,mitochondria related pathways including ROS formation,POX expression and cytochrome c release increased,which were inhibited by pretreatment with GW9662,a specific antagonist of PPARγ.These results illustrated that POX upregulation and ROS formation in apoptosis induced by troglitazone was modulated in PPARγ-dependent pattern.Furthermore,the inhibition of ROS and apoptosis after POX siRNA used in troglitazone-treated HT29 cells indicated that POX be essential in the ROS formation and PPARγ-dependent apoptosis induced by troglitazone.Conclusion The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation,at least partly,via PPARγ activation. | WANG Jing LV XiaoWen SHI JiePing HU XiaoSong DU YuGuo | 2011 | Biomedical and Environmental Sciences2011，24，4： | 1 |
| 8 | Quantitative determination of soybean meal content in compound feeds:comparison of near-infrared spectroscopy and real-time PCR显示文摘 | Hui Li Xiaowen Lv Jing Wang | 2007 | Anal Bioanal Chem2007，389，： | 1 |
| 9 | Near-infrared reflectance spectroscopy based methods for phytase registration in feed industry 显示文摘 | Haifeng Y Xiaowen LV Jing W | 2007 | J Agri Chem2007，55，： | 1 |
| 10 | Quantitative trait loci for morphometric traits in multiple families of common carp(Cyprinus carpio)显示文摘Quantitative trait locus(QTL) mapping is frequently used to understand the genetic architecture of quantitative traits.Herein,we performed a genome scanfor QTL affecting the morphometric characters in eight full-sib families containing 522 individuals using different statistical methods(Sib-pair and half-sib model).A total of 194 QTLs were detected in 25 different regions on 10 linkage groups(LGs).Among them,37 QTLs on five LGs(eight,13,24,40 and 45) were significant(5%genome-wide level),while the remaining 40(1%chromosome-wide level) and 117(5%chromosome-wide level) indicated suggestive effect on those traits.Heritabilities for most morphometric traits were moderate to high,ranging from 0.21 to 0.66,with generally strong phenotypic and genetic correlations between the traits.A large number of QTLs for morphometric traits were co-located,consistent with their high correlations,and may reflect pleiotropic effect on the same genes.Biological pathways were mapped for possible candidate genes on QTL regions.One significantly enriched pathway was identified onLG45,which had a P-value of 0.04 and corresponded to the 'regulation of actin cytoskeleton pathway'.The results are expected to be useful in marker-assisted selection(MAS) and provide valuable information for the study of gene pathway for morphometric and growth traits of the common carp. | Xianhu Zheng Youyi Kuang Weihua Lv Dingchen Cao Zhipeng Sun Wu Jin Xiaowen Sun | 2017 | Science China(Life Sciences)2017，60，3： | 1 |
| 11 | Quantification offishmeal in compound feed using NIR spectroscopy 显示文摘 | LV Xiaowen LI Hui WANG Jing | 2013 | FoodAnal Methods2013，6，3： | 1 |
| 12 | Erratum to“Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach”[Engineering 13(2022)186–196]显示文摘There was a mistake in affiliation a,the correct one should be“MOE Key Laboratory of Marine Genetics and Breeding and Sars-Fang Center,Ocean University of China,Qingdao 266003,China”as updated above;Affiliations c and d should be reversed:Affiliation c should be“Laboratory for Marine Fisheries Science and Food Production Processes,Pilot Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China,”and the affiliation d should be“Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering,Sanya Oceanographic Institution,Ocean University of China,Sanya 572000,China.” | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，，11： | 1 |
| 13 | Can Hybrid Synapse be Formed between Rat Spinal Motor Neurons and Major Pelvic Ganglion Neurons in vitro?显示文摘The purpose of this study is to determine whether synapses can be formed between spinal motor neurons(SMNs)and major pelvic ganglion(MPG)neurons of a rat in vitro.The green fluorescent protein(GFP)-labelled MPG cells were cultured together with SMNs in a specific medium.The synaptic-like contacts established between SMNs and MPG neurons were studied in co-cultures using morphologic and immunocytochemistry approaches.Phase-contrast observation of co-cultures showed apparent SMNs-MPG neurons contacts as early as three or four days in vitro.We demonstrate some evidence of synaptic contacts between SMNs and MPG neurons in vitro by immunostaining with antibody directed against postsynaptic density protein 95(PSD-95).We describe the development process of a defined SMNs-MPG neurons co-culture system.The results suggest that the hybrid synapse formation that may occur between SMNs and MPG neurons in vitro played an essential role in the mechanisms of a regenerated bladder with an artificial somatic-autonomic reflex arc. | CHENG Shigang XIANG Xuan LV Zemin MAO Xiaowen YANG Xinghai | 2021 | Wuhan University Journal of Natural Sciences2021，26，6： | 0 |
| 14 | Present Situation and Enlightenment of Post-Approval Change Management of Drugs in China,USA and EU显示文摘Objective To provide suggestions for further improvement of China’s drug post-approval change management system.Methods The current legal and regulatory requirements of post-approval change management systems of drugs in USA,EU and China were compared and analyzed.Results and Conclusion The post-approval change management of drugs is an important part of the whole life-cycle management of drugs.However,there are still some problems in China’s current post-approval change management systems.According to the model and requirements of the post-approval change management systems of the USA and EU,this paper proposes the following suggestions for the improvement of China’s post-approval change management system.Firstly,electronic files for licensed products should be created.Then,regulatory standards at the national level must be unified.Lastly,the concept of product life cycle management should be implemented. | Lv Xiaowen Huang Zhe | 2023 | Asian Journal of Social Pharmacy2023，18，1： | 0 |
| 15 | Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach显示文摘Targeted genotyping is an extremely powerful approach for the detection of known genetic variations that are biologically or clinically important.However,for non-model organisms,large-scale target geno-typing in a cost-effective manner remains a major challenge.To address this issue,we present an ultrahigh-multiplex,in-solution probe array-based high-throughput diverse marker genotyping(HD-Marker)approach that is capable of targeted genotyping of up to 86000 loci,with coverage of the whole gene repertoire,in what is a 27-fold and six-fold multiplex increase in comparison with the conventional Illumina GoldenGate and original HD-Marker assays,respectively.We perform extensive analyses of var-ious ultrahigh-multiplex levels of HD-Marker(30 k-plex,56 k-plex,and 86 k-plex)and show the power and excellent performance of the proposed method with an extremely high capture rate(about 96%)and genotyping accuracy(about 96%).With great advantages in terms of cost(as low as 0.0006 USD per geno-type)and high technical flexibility,HD-Marker is a highly efficient and powerful tool with broad appli-cation potential for genetic,ecological,and evolutionary studies of non-model organisms. | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，8，6： | 0 |
| 16 | Extension of Switching Costs Antecedents Based on Customers' Social Ties显示文摘The effects of customers' social ties on switching costs have recently attracted researchers' attention.This study formally included customers' social ties as a new antecedent to supplement those elucidated by Burnham in 2003.Through empirical research,this study successfully verified the reliability and validity of items created to measure social ties,and it demonstrated the facilitating effects of social ties as an antecedent on customers' procedural and relational switching costs.Finally,the study lists managerial implications aimed at retaining customers through knowledge of this added antecedent. | SHI Wenhua JI Chen LI Xiaowen TANG Lingshu LV Tingjie | 2014 | China Communications2014，11，1： | 0 |
| 17 | Single-Crystalline Mesoporous Palladium and Palladium-Copper Nanocubes for Highly Efficient Electrochemical CO_(2) Reduction显示文摘Mesoporous single crystals have unique potential in catalysis,but remain unexplored owing to the enormous synthetic challenge that they pose.Herein,we report a facile soft-template method to prepare palladium(Pd)and Pd alloy nanocubes with single-crystallinity and abundant mesoporosity.The successful formation of these exotic nanostructures essentially relies on the cointroduction of cetyltrimethylammonium chloride as the surfactant template and extra Cl^(−) ions as the facet-selective capping agent under well controlled experimental conditions.Thanks to their large surface areas and penetrating mesoporous channels,our products exhibit a great performance for electrochemical CO_(2) reduction.The best sample from alloying palladium with copper enables the efficient formate production with high selectivity(90∼100%)over a broad potential range,and great stability even under the working potential as cathodic as −0.5 V versus a reversible hydrogen electrode.These performance metrics are far superior to previous Pd-based materials,and underscore the structural advantages of our products. | Hao Lv Fang Lv Huaiyu Qin Xiaowen Min Lizhi Sun Na Han Dongdong Xu Yanguang Li Ben Liu | 2022 | CCS Chemistry2022，4，4： | 0 |
| 18 | Porous Metal Nanocrystal Catalysts:Can Crystalline Porosity Enable Catalytic Selectivity?显示文摘Catalytic selectivity is a central issue in the efficiency of catalytic processes.A large number of strategies have been developed to improve the catalytic selectivity of metal catalysts at the atomic and molecular levels,for instance,alloying secondary elements,fabricating metal-support interactions,and introducing surface ligands.Recently,macro/mesoscopic pores and cavities have been demonstrated as an alternative route to promote catalytic selectivity of metal nanocrystal catalysts.The promotion effects of continuous crystalline porosity include(1)more catalytically active sites that accelerate the favorable catalytic routes to targeted products,(2)confined spaces that increase the retention time of key intermediates and remarkably promote the selective catalysis toward desired products,and(3)an optimized electronic structure and coordination environment of active metal sites that tailor the reaction trends of selective catalysis toward desired products.In this minireview,we summarize recent advances in porosity-enabled catalytic selectivity of metal nanocrystal catalysts with focused discussions of CO_(2) reduction electrocatalysis and selective hydrogenation reactions.The mechanisms that allow for the continuous porosity that enables the catalytic selectivity of metal nanocrystal catalysts are discussed in detail.We end this minireview by proposing current challenges and offering future opportunities in this research field. | Xiaowen Min Hao Lv Yusuke Yamauchi Ben Liu | 2022 | CCS Chemistry2022，4，6： | 0 |
| 19 | 深层碳酸盐岩水平井分段酸压技术研究显示文摘碳酸盐岩水平井以常规笼统改造方式为主,酸压裂缝对储层的沟通程度有限。水平井段长,滤失量极大,酸岩反应速度快,酸液损耗严重。因此,需要开展水平井分段酸化压裂工艺技术研究,从分段改造工具的研制入手,形成深层碳酸盐岩水平井分段酸压工艺技术系列。 | 彭超 王建 刘丽姝 陈天应 Liu Lei Qu Xiaowen Lv Guangyu | 2018 | 石化技术2018，25，10： | 0 |
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