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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Ras pathway activation in gliomas:a strategic target for intranasal administration of perillyl alcohol显示文摘 | Da Fonseca CO Linden R Futuro D | | 0，，04： | 1 |
| 3 | Emotion under- standing in children with ADHD显示文摘 | Da Fonseca D Seguier V Santos A | 2009 | Child Psychiatry Hum Dev2009，40，： | 1 |
| 4 | Validition study of the implicit theories of intelligence scale显示文摘 | Da Fonseca D | 2007 | Encephale-Revue De Psychiatrie Clinique Biologique Etherpapeutique2007，33，4： | 1 |
| 5 | Car- diac safety of (neo)adjuvant trastuzumab in the community set- ting : a single-center experience 显示文摘 | da Fonseca LG de Melo Gagliato D Takahashi TK | 2014 | Breast Care ( Basel )2014，9，： | 1 |
| 6 | Ras pathway activation in gliomes:a strategic target for intranesal administration of perillyl alcohol显示文摘 | da Fonseca CO Linden R Future D | 2008 | Arch Immunol Ther Exp (Warsz)2008，56，4： | 1 |
| 7 | Early childhood caries and quality of life:child and parent perspectives显示文摘 | Filstrup SL Briskie D da Fonseca M | 2003 | Pediatr Dent2003，25，5： | 1 |
| 8 | Structural divergence and adaptive evolution in mammalian cytochromes P4502C显示文摘 | D R Fonseca N da Antunes R R A | 2007 | Gene2007，387，12： | 1 |
| 9 | A characterization of titanium anodic oxides by X-ray absorption spectroscopy and grazing X-ray diffraction显示文摘 | da FONSECA C TRAVERSE A TADJEDDINE A BELO M D C | | 0，，1： | 1 |
| 10 | The stable marriage problem with restricted pairs显示文摘 | Dias V M F da Fonseca G D de Figueiredo C M H | 2003 | Theoretical Computer Science2003，306，： | 1 |
| 11 | Mus cular co-contraction during walking and landing from a jump: comparison between genders and influence of activity level显示文摘 | DA FONSECA S T VAZ D V DE AQUINO C F etal | 2006 | J Electromyogr Kinesiol2006，16，3： | 1 |
| 12 | Increased levels of interferon-γprimed by culture filtrate protein antigen and Cp G-ODN immunization do not confer significant protection against Mycobacterium tuberculosis infection显示文摘 | DA FONSECA D M SILVA C L PAULA M O | 2007 | Immunology2007，121，4： | 1 |
| 13 | Ras pathway activation in gliomas : a strategic target for intranasal administration of perillyl alcohol 显示文摘 | da Fonseca C O Linden R Futuro D | 2008 | Arch lmmunol Ther Exp ( Warsz )2008，56，4： | 1 |
| 14 | Theory of mind in Asperger syndrome显示文摘 | Duverger H Da Fonseca D Bailly D | 2007 | L''Encéphale2007，33，4： | 1 |
| 15 | How to increase academic performance in children with oppositional defiant disorder?An implicit theory effect显示文摘 | Da Fonseca D Cury F Santos A | 2010 | J Behav Ther Exp Psychiatry2010，41，3： | 1 |
| 16 | Typical Emotion Processing for Cartoon but not for Real Faces in Children with Autistic Spectrum Disorders 显示文摘 | Rosset DB Rondan C Da Fonseca D | 2008 | Journal of Autism and Developmental Disorders2008，38，： | 1 |
| 17 | Global biodiversity conservation priorities显示文摘 | Brooks T M Mittermeier R A da Fonseca G A B Gerlach J Hoffmann M Lamoreux J F Mittermeier C G Pilgrim J D Rodrigues A S L | 2006 | Science2006，313，： | 1 |
| 18 | Study of optical properties of Cr3+ ions in Cs2NaAIF6 single crystals显示文摘 | Sosman L P Tavares A D da Fonseca R M | 2000 | Solid State Commun2000，114，12： | 1 |
| 19 | Detection of the Pandemic O25-ST131 human virulent Escherichia coli CTX M 15-producing clone harboring the qnrB2 and aac(6r)-Ib-cr genes in a dog显示文摘 | Pomba C da Fonseca J D Baptista B C | 2009 | Antimicrobial Agents and Chemotherapy2009，53，1： | 1 |
| 20 | The influence of rolling tempera- ture on texture evolution and variant selection duringβ→α phase transformation in Ti-6A14V 显示文摘 | Obasi G C Birosca S Leo Prakash D G Quinta da Fonseca J Preuss M | 2012 | Acta Ma- terialia2012，60，17： | 1 |
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