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| 1 | 二期尿道成型术更适合于需要横断尿道板并伴有严重弯曲畸形的近段型尿道下裂显示文摘对于伴有严重阴茎弯曲的尿道下裂,横断尿道板后是选择一期还是二期手术仍存在争议。这项回顾性研究比较评价了这两种方法的优劣。本研究共收集66例伴有严重阴茎弯曲的近端型尿道下裂的患者,根据手术方式分成两组,其中32例行一期手术(Duckett),34例行二期手术。一期和二期手术组的中位年龄分别为7.5岁和11.0岁,中位随访时间分别为28.5个月和35个月。所有患者术后尿道外口均位于龟头顶端。随访期间无患者出现阴茎弯曲复发,患者及其家属对阴茎的长度和外观均满意。术后两组各有8例患者出现并发症,两组间并发症率无统计学差异。一期手术尿道狭窄的远期并发症率高j(18.75%1,JO%)。在一期手术组中,青春期前患者的并发症率显著低于青春期后患者(10.52%w46.15%3。中期随访结果提示,横断尿道板可有效矫正近端型尿道下裂合并的重度阴茎弯曲。考虑到一期手术组中较高的尿道狭窄发生率,本文认为分期手术更适合伴有严重阴茎弯曲需要横断尿道板的近端型尿道下裂。 | Da-Chao Zheng Hai-Jun Yao Zhi-Kang Cai Jun Da Qi Chen Yan-Bo Chen Ke Zhang Ming-Xi Xu Mu-Jun Lu Zhong Wang | 2015 | Asian Journal of Andrology2015，17，1： | 13 |
| 2 | A new iridoid glycoside from Paederia scandens显示文摘A new glycoside named 6β-O-β-D-glucosylpaederosidic acid(1) was isolated from Paederia scandens and its structure was elucidated on the basis of spectroscopic and chemical evidence,together with four known iridoids,paederoside(2),paederosidic acid(3),paederosidic acid methyl ester(4),and deacetyl asperulosidic acid methyl ester(5).Compound 5 was isolated from this plant for the first time. | He, Da Hai Chen, Jin Song Wang, Xiao Ling Ding, Ke Yi | 2010 | Chinese Chemical Letters2010，21，4： | 5 |
| 3 | Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and Liquid Chromatography-electrospray Ionization-mass Spectrometry Method显示文摘Metabolism of four tobacco-specific N-nitrosamines (TSNAs), N′-nitrosonornicotine (NNN), N′-nitrosoanatabine (NAT), N′-nitrosoanabasine (NAB) and 4-(methyl nitrosamino)-1- (3-pyridyl)-1-butanone (NNK) was studied by solid-phase extraction (SPE) and liquid chromato- graphy-electrospray ionization-mass spectrometry (LC-ESI-MS). SPE and LC-ESI-MS method was evaluated to be rapid, simple, sensitive and selective for analysis of TSNAs in rabbit serum. The doses of TSNAs administrated were 4.666 μgkg and 11.665 μgkg according to different levels in cigarettes. Metabolic curves of four TSNAs and 4-(methyl nitrosamino)-1-(3-pyridyl)- 1-butanone (NNAL), the metabolite of NNK, were obtained. | Jian Xun ZHANG Chen Chen LI Zheng CHEN Zhi Hua RAO Da Wei WEN Ke An LI Hu Wei LIU | 2005 | Chinese Chemical Letters2005，16，12： | 5 |
| 4 | Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality显示文摘Climate change is the greatest environmental threat to humans and the planet in the 21st century.Global anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate events.Cumulative carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse gases.Therefore,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target setting.Currently,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by 2060.The development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction policies.Near-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this discipline.This article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application trends.We also present a framework for the latest near-real-time carbon emission accounting technology that can be widely used.The development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”strategy.Finally,this article provides an outlook on the future of real-time carbon emission monitoring technology. | Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng Chenxi Lu Da Huo Xiang Ding | 2022 | Engineering2022，8，7： | 5 |
| 5 | Granular porous calcium carbonate particles for scalable and high-performance solar-driven thermochemical heat storage显示文摘Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density,low cost,and high operation temperature.Researchers have tried to improve energy storage performances of calcium carbonate recently,but most researches focus on powders,which are not suitable for scalable applications.Here,novel granular porous calcium carbonate particles with very high solar absorptance,energy storage density,abrasive resistances,and energy storage rate are proposed for direct solar thermochemical heat storage.The average solar absorptance is improved by 234%compared with ordinary particles.Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill.In addition,the decomposition temperature is reduced by 2.8%–5.6%while the reaction rate of heat storage is enhanced by 80%–205%depending on the CO_(2) partial pressure.The decomposition process of doped granular porous CaCO_(3) particles is found to involve three overlapping processes.This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems. | SONG Chao LIU XiangLei XUAN YiMin ZHENG HangBin GAO Ke TENG Liang DA Yun LI Chuan LI YongLiang DING YuLong | 2021 | Science China(Technological Sciences)2021，64，10： | 4 |
| 6 | A new tetrastilbene from Caragana sinica显示文摘新 tetrastilbene 说出 carasinol D (1 ) 的 A 从锦鸡儿属植物 sinica 的根被孤立。它的结构被分光镜的分析阐明。化合物 1 被催化酸的变换从 carasinol B (2 ) 获得。 | Ke Jun Cheng Da You Ma Guo Xun Yang Chang Qi Hu | 2008 | Chinese Chemical Letters2008，19，6： | 4 |
| 7 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 8 | New Geochronologic Evidence of Diabases and Their Metallogenic Relationship with the Makeng-Type Iron Deposits in Southwest Fujian, SE China显示文摘Objective The Makeng-type iron deposits are located in Late Paleozoic depression of southwest Fujian Province in the southeast edge of Cathaysia,which are famous for their huge scale and specific ore genesis.Previous studies mainly focus on the ore characteristics,metallogenic setting and the granites in the mining area,and there is still controversy on the ore genesis.Recent research | WANG Sen ZHANG Da WU Ganguo CAO Ke QU Hongjie MA Shuai YU Tengda | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 3 |
| 9 | Influence of Diesel Engine Intake Throttle and Late Post Injection Process on the Rise of Temperature in the Diesel Oxidation Catalyst显示文摘In order to effectively implement DPF(Diesel Particulate Filters)regeneration control,thermal management of exhaust products before and inside Diesel Oxidation Catalyst(DOC)is necessary.In the present study,the Influence of the intake throttle valve and late post injection process on temperature rise inside DOC is analyzed through engine bench tests.The steady experiment results show that adjustment of the intake throttle valve can effectively increase exhaust temperature before DOC;in particular,with intake throttle valve opening at 20%,temperature before DOC can be increased by about 170℃ with respect to the full opening.An increase in the late post injection quantity can produce a significant rise of the temperature inside DOC,however its impact on the exhaust temperature before DOC is relatively limited.As the late post injection quantity increases,Hydrocarbon(HC)emissions also grow;in the present work it is shown that with a proper injection quantity,a considerable temperature increase inside the DOC can be obtained with relatively low HC emission.More specifically,with the intake throttle valve at 30%and DOC reaching ignition temperature as the late post injection quantity is increased,the exhaust temperature after DOC can be made larger than 550℃,adequate for DPF active regeneration. | Ke Sun Da Li Hao Liu Shuzhan Bai | 2020 | Fluid Dynamics & Materials Processing2020，16，3： | 3 |
| 10 | Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury显示文摘 | Zhang Lei Zhang Wei - Ping Chen Ke - Da Qian Xiao - Dong Fang San - Hua Wei Er - Qing | 2006 | 中国药理通讯2006，23，4： | 3 |
| 11 | Comparison of renal disease severity and outcome in patients with primary antiphospholipid syndrome, antiphospholipid syndrome secondary to systemic lupus erythematosus (SLE) and SLE alone显示文摘 | Moss KE Isenberg DA | 2001 | Rheumatology (Oxford)2001，40，8： | 1 |
| 12 | Amurine model for the effects of pelvic radiation and cisplatin chemotherapy an human papillomavirus vaccine efficacy显示文摘 | Da Silva DM De Visser KE | 2001 | Clin Cancer Res2001，79，3： | 1 |
| 13 | Genetic polymorphisms and the pro-gression of liver fibrosis:Acritical appraisal显示文摘 | North KE Brenner DA | 2003 | Hepatology2003，37，3： | 1 |
| 14 | Comparison of pavhk harness application and immediate spica casting for femur fractures in infants显示文摘 | Podeszwa DA Mooney JF 3rd Cramer KE | 2004 | J Pediatr Orthop2004，24，5： | 1 |
| 15 | Angiotensin II type 1 receptor pol-ymorphisms and susceptibility to hypertension: a HuGE review 显示文摘 | Mottl AK Shoham DA North KE | 2008 | Genet Med2008，10，8： | 1 |
| 16 | Infarction of an extralobar pulmonary sequestration in a young child:diagnosis and excision by video-assisted thoracoscopy显示文摘 | Uchida DA Moore KR Wood KE | 2010 | J Laparoendosc Adv Surg Tech A2010，20，4： | 1 |
| 17 | Integration of a formalized handoff system into the surigical curriculum: Resident perspectives and early results 显示文摘 | Telem DA Bueh KE EHis S et at | 2011 | Arch Surg2011，146，1： | 1 |
| 18 | Predictors,prevention,and longterm prognosis of atrial fibrillation after coronary artery bypass graft operations显示文摘 | Rubin DA Nieminski KE Reed GE | 1987 | J Thorac Cardiovasc Surg1987，94，： | 1 |
| 19 | HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells 显示文摘 | Iles KE Dickinson DA Wigley AF | 2005 | Free Radic Biol Med2005，39，3： | 1 |
| 20 | Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets显示文摘Dear Editor,Bile acids are a group of cholesterol-derived physiological surfactants required for digestion of lipids and fat-soluble vitamins.1However,excess of bile acids is detrimental to metabolic homeostasis and bile acid imbalance can contribute to cancer progression.2Bile acids are produced primarily in the liver and then secreted to the bile duct before delivery to the small intestine,where up to 95%of bile acids are reabsorbed and recirculated to the liver(Supplementary information,Fig.S1a).The primary bile acids are biosynthesized in hepatocytes via oxidation of cholesterol and modified by either taurine or glycine,forming the conjugated primary bile acids which harbor a cholic acid moiety and a taurine/glycine moiety(Supplementary information,Fig.S1 b).This enterohepatic circulation of bile acids is driven by a series of transmembrane transporters(Supplementary informa-tion,Fig.S1a),including the ATP-binding cassette(ABC)transpor-ter ABCB11(also termed bile salt export pump BSEP). | Liang Wang Wen-Tao Hou Jie Wang Da Xu Cong Guo Linfeng Sun Ke Ruan Cong-Zhao Zhou Yuxing Chen | 2022 | Cell Research2022，32，5： | 1 |
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