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| 1 | Apical hypertrophic cardiomyopathy显示文摘We describe a patient with asymptomatic apical hypertrophic cardiomyopathy(AHCM)who later developed cardiac arrhythmias,and briefly discuss the diagnostic modalities,differential diagnosis and treatment option for this condition.AHCM is a rare form of hypertrophic cardiomyopathy which classically involves the apex of the left ventricle.AHCM can be an incidental finding,or patients may present with chest pain,palpitations,dyspnea,syncope,atrial fibrillation,myocardial infarction,embolic events,ventricular fibrillation and congestive heart failure.AHCM is frequently sporadic,but autosomal dominant inheritance has been reported in few families.The most frequent and classic electrocardiogram findings are giant negative T-waves in the precordial leads which are found in the majority of the patients followed by left ventricular(LV)hypertrophy.A transthoracic echocardiogram is the initial diagnostic tool in the evaluation of ACHM and shows hypertrophy of the LV apex.AHCM may mimic other conditions such as LV apical cardiac tumors,LV apical thrombus,isolated ventricular non-compaction,endomyocardial fibrosis and coronary artery disease.Other modalities,including left ventriculography,multislice spiral computed tomography,and cardiac magnetic resonance imagings are also valuable tools and are frequently used to differentiate AHCH from other conditions.Medications used to treat symptomatic patients with AHCM include verapamil,beta-blockers and antiarrhythmic agents such as amiodarone and procainamide.An implantable cardioverter defibrillator is recommended for high risk patients. | Syed Wamique Yusuf Jaya D Bathina Jose Banchs Elie N Mouhayar Iyad N Daher | 2011 | World Journal of Cardiology2011，3，7： | 4 |
| 2 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 3 | Radioimmunolocalization of themonoclonal antibody J28 in early transformation stages in N-nitrosobis(2-hydroxypropyl) amine-induced pancreatictumors in the Syrian golden hamster显示文摘 | Takeda Y Miralles F Daher N | 1992 | J canceer Res Clin Oncol1992，118，： | 1 |
| 4 | Induction of rat intestinal carcinogenesis with single doses, low and high repeated doses of 1,2-dimethylhydrazine 显示文摘 | Decaens C Gautier R Daher N | 1989 | Carcinogenesis1989，10，1： | 1 |
| 5 | HLA-G expression in melanoma:a way for cells to escape from immunosurveillance显示文摘 | Paul P Rous Freiss N Khalil Daher Ⅰ | 1998 | Proc Natl Acad Sci1998，95，8： | 1 |
| 6 | Associations between cytokine gene polymorphisms and recurrent pregnancy loss显示文摘 | Daher S Shulzhenko N Morgun A | 2003 | J Reprod Immunol2003，58，1： | 1 |
| 7 | Seasonal and spatial variation in reactive oxygen species activity of quasi-ultrafine particles in the Los Angeles Metropolitan area and its association with chemical composition显示文摘 | Saffari A Daher N Shafer M M | 2013 | Atmos Environ2013，77，： | 1 |
| 8 | Congenital prepubic sinus显示文摘 | DAHER P DIAB N MOUSSA C | 1994 | Eur J Pediatr Surg1994，4，： | 1 |
| 9 | 显示文摘 | Khalil Daher I Rouas-Freiss N Carosella ED | 2000 | World J Surg2000，24，7： | 1 |
| 10 | Cytokine genotyping in preeclampsia显示文摘 | Daher S Sass N Oliveira LG | 2006 | Am J Reprod Immunol2006，55，2： | 1 |
| 11 | HLA-G expres sion in melanoma: A way for tumor cells to escape from immu nosurveillance显示文摘 | Paul P Rouas Freiss N Khalil Daher I | 1998 | Immunol1998，59，8： | 1 |
| 12 | Bioremediation of oil contaminated soil: microbiological methods for feasibility assessment and eld evaluation显示文摘 | Balba M T Awadhi A N Daher A R | 1998 | J Microbiol Methods1998，32，2： | 1 |
| 13 | Bioremediatlon of oil contaminated soil: Microbiological methods for feasibility assessment and eld evaluation显示文摘 | Balba M T Awadhi A N Daher A R | 1998 | J Microbial Methods1998，32，2： | 1 |
| 14 | Congenital cyst of the pancreas: antenatal diagnosis显示文摘 | Daher P Diab N Melki I | 1996 | Eur J Pediatr Surg1996，6，3： | 1 |
| 15 | Particulatematter (PM) concentrations in underground and ground-level rail systems of the Los Angeles metro显示文摘 | KAM W CHEUNG K DAHER N | 2011 | Atmospheric Environment2011，45，8： | 1 |
| 16 | HLA- G expression in melanoma: A way for tumor cells to escape from immunosurveillance显示文摘 | Paulp P Rouas- Freiss N Khali - daher I | 1998 | Proc Nail Acad Sci USA1998，95，8： | 1 |
| 17 | Particulate matter(PM)concentrations in underground and ground-level rail systems of the Los Angeles Metro显示文摘 | KAM W CHEUNG K DAHER N | 2011 | Atmospheric Environment2011，45，8： | 1 |
| 18 | Cytokine genotyping in preeclampsia显示文摘 | Daher S Sass N Oliveira LG | 2006 | Am J Reprod Immunol2006，55，2： | 1 |
| 19 | Particulate matter(PM)concentrations in underground and ground-level rail systems of the Los Angeles metro显示文摘 | KAM W CHEUNG K DAHER N | 2011 | Atmospheric Environment2011，45，8： | 1 |
| 20 | Energy Analysis of an Original Steering Technology That Saves Fuel and Boosts Efficiency 显示文摘 | Daher N Ivantysynova M | 2014 | Energy Conversion and Management2014，，86： | 1 |
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