| 3 | Functional near-infrared spectroscopy in non-invasive neuromodulation显示文摘Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases. | Congcong Huo Gongcheng Xu Hui Xie Tiandi Chen Guangjian Shao Jue Wang Wenhao Li Daifa Wang Zengyong Li | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 4 | Fast optical wavefront engineering for controlling light propagation in dynamic turbid media显示文摘While propagating inside the strongly scattering biological tssue,photons lose their incident directions beyond one transport mean free path(TMFP,~1 millimeter(mm)),which makes it challenging to achieve optical focusing or clear imaging deep inside tissue.By manipulating many degrees of the incident optical wavefront,the latest optical wavefront engineering(WFE)technology compensates the wavelfront distortions caused by the scattering media and thus is toward breaking this physical limit,bringing bright perspective to many applications deep inside tissue,eg,high resolution functional/molecular imaging,optical excitation(optogenetics)and optical tweezers.However,inside the dynamic turbid media such as the biological tissue,the wavefront distortion is a fast and continuously changing process whose decorrelation rate is on timescales from milliseconds(ms)to microseconds(μs),or even faster.This requires that the WFE technology should be capable of beating this rapid process.In this review,we discuss the major challenges faced by the WFE technology due to the fast decorrelation of dynamic turbid media such as living tissue when achieving light focusing/imaging and summarize the research progress achieved to date to overcome these challenges. | Meiyun Xia Deyu Li Ling Wang Daifa Wang | 2019 | Journal of Innovative Optical Health Sciences2019，，4： | 0 |
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