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| 1 | Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice显示文摘 | Wenhao Yan Haiyang Liu Xiangchun Zhou Qiuping Li Jia Zhang Li Lu Touming Liu Haijun Liu Chengjun Zhang Zhanyi Zhang Guojing Shen Wen Yao Huaxia Chen Sibin Yu Weibo Xie Yongzhong Xing | 2013 | Cell Research2013，23，7： | 39 |
| 2 | Geochronology, geochemistry, and its geological significance of the Permian Mandula mafic rocks in Damaoqi, Inner Mongolia显示文摘The Hujierte-Chaganhadamiao volcanic-plutonic sequence is located in the Mandula area of northern Damaoqi, Inner Mongolia. It contains mainly mafic volcanics, with several ultramafic blocks in its central part and mafic-intermediate intrusions in the east. The zircon U-Pb ages of the gabbro and basalt samples are 278.5±3.0 Ma (MSWD=0.66) and 273.7±1.0 Ma (MSWD=0.36), respectively. These ages constrain the magmatism occurred in the Early Permian. The Mandula Permian mafic rocks are characterized by low abundances of REE and slightly LREE-enriched chondrite-normalized N-MORB-type REE patterns. And these mafic samples have high ( 143 Nd/ 144 Nd) i (0.51262-0.51270), relatively high positive ε Nd (t) (3.4-8.0), and high Mg # (49-54), suggesting derivation from the depleted asthenosphere mantle source. But they also show the enrichment in large ion lithophile elements (LILE, e.g. Rb, Ba and Sr), depletion in high field strength elements (HFSE); distinctly negative Nb, Ta anomalies and slightly negative P, Ti anomalies; high ( 87 Sr/ 86 Sr) i (0.70490-0.70537), low ( 206 Pb/ 204 Pb) i (17.39-17.93). All of these resemble the characteristics of the enriched mantle source or involvement of arc materials in the magma genesis. Furthermore, as shown in the correlation plots of ε Nd (t) vs ( 87 Sr/ 86 Sr) i , ( 206 Pb/ 204 Pb) i vs ( 207 Pb/ 204 Pb) i and ( 208 Pb/ 204 Pb) i , La/Ba La/Nb vs La/Nb, and La/Nb ratio, the magma source could have been experienced the contamination and metasomation from the previous subduction process. And the positive correlation between the selected major oxides and trace elements could be explained by the contamination from continental crust and arc materials during the magmatic emplacement. Combined with the distinct geochemistry features of Mandula mafic samples and many previous researches in the study area, the Early Permian magmatism in Mandula occurred under an extensional rift setting, and a juvenile ocean basin probably had already been formed after further development. | CHEN Chen ZHANG ZhiCheng GUO ZhaoJie LI JianFeng FENG ZhiShuo TANG WenHao | 2012 | Science China Earth Sciences2012，55，1： | 30 |
| 3 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 4 | ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds显示文摘 | Yao, Ruifeng Wang, Fei Ming, Zhenhua Du, Xiaoxi Chen, Li Wang, Yupei Zhang, Wenhao Deng, Haiteng Xie, Daoxin | 2017 | Cell Research2017，27，6： | 15 |
| 5 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 6 | Effects of combined drip irrigation and sub-surface pipe drainage on water and salt transport of saline-alkali soil in Xinjiang, China显示文摘Developing effective irrigation and drainage strategies to improve the quality of saline-alkali soil is vital for enhancing agricultural production and increasing economic returns. In this study, we explored how irrigation and drainage modes (flood irrigation, drip irrigation, and sub-surface pipe drainage under drip irrigation) improve the saline-alkali soil in Xinjiang, China. We aimed to study the transport characteristics of soil water and salt under different irrigation and drainage modes, and analyze the effects of the combination of irrigation and drainage on soil salt leaching, as well as its impacts on the growth of oil sunflower. Our results show that sub-surface pipe drainage under drip irrigation significantly reduced the soil salt content and soil water content at the 0–200 cm soil depth. Under sub-surface pipe drainage combined with drip irrigation, the mean soil salt content was reduced to below 10 g/kg after the second irrigation, and the soil salt content decreased as sub-surface pipe distance decreased. The mean soil salt content of flood irrigation exceeded 25 g/kg, and the mean soil desalination efficiency was 3.28%, which was lower than that of drip irrigation. The mean soil desalination rate under drip irrigation and sub-surface pipe drainage under drip irrigation was 19.30% and 58.12%, respectively. After sub-surface drainage regulation under drip irrigation, the germination percentage of oil sunflower seedlings was increased to more than 50%, which further confirmed that combined drip irrigation and sub-surface pipe drainage is very effective in improving the quality of saline-alkali soil and increasing the productivity of agricultural crops. | HENG Tong LIAO Renkuan WANG Zhenhua WU Wenyong LI Wenhao ZHANG Jinzhu | 2018 | Journal of Arid Land2018，10，6： | 12 |
| 7 | Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus显示文摘Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region.Three-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone repair.Here,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG scaffolds.Moreover,MSNs sustainably released BMP-4 for long-term effectiveness.In 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory factors.BMP-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted scaffolds.Furthermore,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory microenvironment.And 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone repair.In conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2. | Xin Sun Zhenjiang Ma Xue Zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang Jinzhong Zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang | 2021 | Bioactive Materials2021，6，3： | 12 |
| 8 | Rectangle expansion A* pathfinding for grid maps显示文摘Search speed, quality of resulting paths and the cost of pre-processing are the principle evaluation metrics of a pathfinding algorithm. In this paper, a new algorithm for grid-based maps,rectangle expansion A*(REA*), is presented that improves the performance of A*significantly.REA*explores maps in units of unblocked rectangles. All unnecessary points inside the rectangles are pruned and boundaries of the rectangles(instead of individual points within those boundaries)are used as search nodes. This makes the algorithm plot fewer points and have a much shorter open list than A*. REA*returns jump and grid-optimal path points, but since the line of sight between jump points is protected by the unblocked rectangles, the resulting path of REA*is usually better than grid-optimal. The algorithm is entirely online and requires no offline pre-processing. Experimental results for typical benchmark problem sets show that REA*can speed up a highly optimized A*by an order of magnitude and more while preserving completeness and optimality. This new algorithm is competitive with other highly successful variants of A*. | Zhang An Li Chong Bi Wenhao | 2016 | Chinese Journal of Aeronautics2016，29，5： | 10 |
| 9 | Mesozoic and Cenozoic uplift and exhumation of the Bogda Mountain,NW China: Evidence from apatite fission track analysis显示文摘Apatite fission track(AFT)analysis on samples collected from a Paleozoic series is used to constrain the cooling history of the Bogda Mountain,northwest China.AFT ages range from 136.2 to 85.6 Ma and are younger than rock depositional ages and the mean confined track lengths(11.0e13.2 mm)mostly showing unimodal distribution are shorten,indicating significant track-annealing.Thermal histories modeling based on the distribution of fission-track lengths combined with the regional geological data show that two rapid cooling phases occurred in the latest Jurassiceearly Cretaceous and the OligoceneeMiocene.Those new data together with previous published data show that the AFT ages become younger from the southwest to northeast in the western Bogda Mountain and its adjacent areas.The fission-track ages of the southwest area are relatively older(>100 Ma),recording the earlier rapid uplift phase during the late JurassiceCretaceous,while the ages in the north piedmont of the Bogda Mountain(namely the northeast part)are younger(<60 Ma),mainly reflecting the later rapid uplift phase in the OligoceneeMiocene.The trend of younger AFT ages towards the northeast might be explained by post-Cretaceous large-scale crustal tilting towards the southwest.In the thrust fault-dominated northern limbs of the Bogda Mountain,AFT ages reveal a discontinuous pattern with age-jumps across the major fault zones,showing a possible strata tilting across each thrust faults due to the thrust ramps during the Cenozoic.The two rapid uplift stages might be related to the accretion and collision in the southern margin of the Asian continent during the late Jurassic and late Cenozoic,respectively. | Wenhao Tang Zhicheng Zhang Jianfeng Li Ke Li Zhiwen Luo Yan Chen | 2015 | Geoscience Frontiers2015，6，4： | 9 |
| 10 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 11 | In vitro degradation and biocompatibility evaluation of typical biodegradable metals (Mg/Zn/Fe) for the application of tracheobronchial stenosis显示文摘Tracheobronchial obstruction in children due to benign stenosis or tracheobronchomalacia still remains a challenging matter of concern.Currently,there is 10%–20%complication rate in clinical treatment.The nonbiodegradable property of silicone stents and nickel-titanium memory alloy stents take the primary responsibility for drawbacks including stimulating local granulation tissue proliferation,displacement,and stent-related infections.Permanent tracheobronchial stent will be a persistent foreign object for a long time,causing excessive secretion of tracheal mucosa,ulceration and even perforation,which is particularly unsuitable for young children with persistent tracheal growth.In this study,the degradation and biocompatibility performance of three typical biodegradable metals were investigated as potential tracheobronchial stent materials.The results exhibited that these materials showed different degradation behaviors in the simulating respiratory fluid environment compared with SBF.Except for pure iron group,high purity magnesium and zinc showed favorable cell adhesion and proliferation in three culture methodologies(direct culture,indirect culture and extraction culture).The proper corrosion rate and good biocompatibility indicated that high purity magnesium and zinc may be good candidates as tracheobronchial stent materials. | Yangyang Li Jianglong Yan Wenhao Zhou Pan Xiong Pei Wang Wei Yuan Yufeng Zheng Yan Cheng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 12 | Facile synthesis of bimodal macroporous g-C_3N_4/SnO_2 nanohybrids with enhanced photocatalytic activity显示文摘It is of vital importance to construct highly interconnected,macroporous photocatalyst to improve its efficiency and applicability in solar energy conversion and environment remediation.Graphitic-like C_3N_4(g-C_3N_4),as an analogy to two-dimensional(2D)graphene,is highly identified as a visible-lightresponsive polymeric semiconductor.Moreover,the feasibility of g-C_3N_4 in making porous structures has been well established.However,the preparation of macroporous g-C_3N_4 with abundant porous networks and exposure surface,still constitutes a difficulty.To solve it,we report a first facile preparation of bimodal macroporous g-C_3N_4 hybrids with abundant in-plane holes,which is simply enabled by in-situ modification through thermally treating the mixture of thiourea and SnCl_4(pore modifier)after rotary evaporation.For one hand,the formed in-plane macropores endow the g-C_3N_4 system with plentiful active sites and short,cross-plane diffusion channels that can greatly speed up mass transport and transfer.For another,the heterojunctions founded between g-C_3N_4 and SnO_2 consolidate the electron transfer reaction to greatly reduce the recombination probability.As a consequence,the resulted macroporous gC_3N_4/SnO_2 nanohybrid had a high specific surface area(SSA)of 44.3 m^2/g that was quite comparable to most nano/mesoporous g-C_3N_4 reported.The interconnected porous network also rendered a highly intensified light absorption by strengthening the light penetration.Together with the improved mass transport and electron transfer,the macroporous g-C_3N_4/SnO_2 hybrid exhibited about 2.4-fold increment in the photoactivity compared with pure g-C_3N_4.Additionally,the recyclability of such hybrid could be guaranteed after eight successive uses. | Yingzhi Chen Wenhao Li Dongjian Jiang Kuo Men Zhen Li Ling Li Shizheng Sun Jingyuan Li Zheng-Hong Huang Lu-Ning Wang | 2019 | Science Bulletin2019，64，1： | 7 |
| 13 | The main controlling factors and developmental models of Oligocene source rocks in the Qiongdongnan Basin,northern South China Sea显示文摘Coals developed in the Oligocene Yacheng and Lingshui formations in the Qiongdongnan Basin have high organic matter abundance,and the dark mudstones in the two formations have reached a good source rock standard but with strong heterogeneity.Through the analysis of trace elements,organic macerals and biomarkers,it is indicated that plankton has made little contribution to Oligocene source rocks compared with the terrestrial higher plants.The organic matter preservation depends on hydrodynamics and the redox environment,and the former is the major factor in the study area.During the sedimentary period of the Yacheng Formation,tidal flats were developed in the central uplift zone,where the hydrodynamic conditions were weak and the input of terrestrial organic matter was abundant.So the Yacheng Salient of the central uplift zone is the most favorable area for the development of source rocks,followed by the central depression zone.During the sedimentary period of the Lingshui Formation,the organic matter input was sufficient in the central depression zone due to multiple sources of sediments.The semi-enclosed environment was favorable for organic matter accumulation,so high quality source rocks could be easily formed in this area,followed by the Yacheng salient of central uplift zone.Source rocks were less developed in the northern depression zone owing to poor preservation conditions. | Li Wenhao Zhang Zhihuan Li Youchuan Liu Chao Fu Ning | 2013 | Petroleum Science2013，10，2： | 7 |
| 14 | Magnetic performance and corrosion resistance of electroless plating CoWP film显示文摘The CoWP film with good magnetic performance and corrosion resistance was electrolessly plated from alkaline solution. The technical parameters of the electroless plating system were optimized. When the pH value of electroless plating solution was 11.0 and the reducing agent (NaH2PO2) content was 0.4 mol L 1, the target chemical reactions proceeded in the electroless plating solution smoothly with negligible interference and side effects. CoWP film prepared under optimal deposition condition contained more hexagonal close-packed (hcp) cobalt (ε-Co) of [110] and crystallographic orientation of Co [002]. VSM analysis reveals that the saturation magnetization of the CoWP film is 100~220 Am2 kg 1 and coercivity is (2.87~4.38)×104 A·cm 1. The corrosion behavior of CoWP film in 3.5% NaCl aqueous solution was studied by electrochemical experiments. The results prove that the corrosion resistance of the CoWP film deposited under the optimal depo-sition condition exhibites relatively lower corrosion current of (3.054~3.162)×10 6 A·cm 2. The surface morphology analysis indicates that the film is smooth and composed of regular-shaped crystallites. | Jiang, Li Pan, Shanshan Lu, Jianbiao Ke, Xin He, Wenhao Yu, Yundan Wei, Guoying Ge, Hongliang | 2012 | Rare Metals2012，31，3： | 6 |
| 15 | Simple β-lactones are potent irreversible antagonists for strigolactone receptors显示文摘 | Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo | 2017 | Cell Research2017，27，12： | 5 |
| 16 | Analysis of grinding mechanics and improved grinding force model based on randomized grain geometric characteristics显示文摘Too high grinding force will lead to a large increase in specific grinding energy, resulting in high temperature in grinding zone, especially for the aerospace difficult cutting metal materials,seriously affecting the surface quality and accuracy. At present, the theoretical models of grinding force are mostly based on the assumption of uniform or simplified morphological characteristics of grains, which is inconsistent with the actual grains. Especially for non-engineering grinding wheel,most geometric characteristics of grains are ignored, resulting in the calculation accuracy that cannot guide practical production. Based on this, an improved grinding force model based on random grain geometric characteristics is proposed in this paper. Firstly, the surface topography model of CBN grinding wheel is established, and the effective grain determination mechanism in grinding zone is revealed. Based on the known grinding force model and mechanical behavior of interaction between grains and workpiece in different stages, the concept of grain effective action area is proposed. The variation mechanism of effective action area under the influence of grain geometric and spatial characteristics is deeply analyzed, and the calculation method under random combination of five influencing parameters is obtained. The numerical simulation is carried out to reveal the dynamic variation process of grinding force in grinding zone. In order to verify the theoretical model, the experiments of dry grinding Ti-6Al-4 V are designed. The experimental results show that under different machining parameters, the results of numerical calculation and experimental measurement are in good agreement, and the minimum error value is only 2.1 %, which indicates that the calculation accuracy of grinding force model meets the requirements and is feasible. This study will provide a theoretical basis for optimizing the wheel structure, effectively controlling the grinding force range, adjusting the grinding zone temperature and improving the workpiece machining quality in the industrial grinding process. | Mingzheng LIU Changhe LI Yanbin ZHANG Min YANG Teng GAO Xin CUI Xiaoming WANG Wenhao XU Zongming ZHOU Bo LIU Zafar SAID Runze LI Shubham SHARMA | 2023 | Chinese Journal of Aeronautics2023，36，7： | 5 |
| 17 | Intelligent classification model of surrounding rock of tunnel using drilling and blasting method显示文摘Classification of surrounding rock is the cornerstone of tunnel design and construction.The traditional methods are mainly qualitative and manual and require extensive professional knowledge and engineering experience.To minimize the effect of the empirical judgment on the accuracy of surrounding rock classification,it is necessary to reduce human participation.An intelligent classification technique based on information technology and artificial intelligence could overcome these issues.In this regard,using 299 groups of drilling parameters collected automatically using intelligent drill jumbos in tunnels for the Zhengzhou-Wanzhou high-speed railway in China,an intelligent-classification surrounding-rock database is constructed in this study.Based on a machine learning algorithm,an intelligent classification model is then developed,which has an overall accuracy of 91.9%.Finally,using the core of the model,the intelligent classification system for the surrounding rock of drilled and blasted tunnels is integrated,and the system is carried by intelligent jumbos to perform automatic recording and transmission of drilling parameters and intelligent classification of the surrounding rock.This approach provides a foundation for the dynamic design and construction(both conventional and intelligent)of tunnels. | Mingnian Wang Siguang Zhao Jianjun Tong Zhilong Wang Meng Yao Jiawang Li Wenhao Yi | 2021 | Underground Space2021，6，5： | 5 |
| 18 | Electrostatic atomization minimum quantity lubrication machining:from mechanism to application显示文摘Metal cutting fluids(MCFs)under flood conditions do not meet the urgent needs of reducing carbon emission.Biolubricant-based minimum quantity lubrication(MQL)is an effective alternative to flood lubrication.However,pneumatic atomization MQL has poor atomization properties,which is detrimental to occupational health.Therefore,electrostatic atomization MQL requires preliminary exploratory studies.However,systematic reviews are lacking in terms of capturing the current research status and development direction of this technology.This study aims to provide a comprehensive review and critical assessment of the existing understanding of electrostatic atomization MQL.This research can be used by scientists to gain insights into the action mechanism,theoretical basis,machining performance,and development direction of this technology.First,the critical equipment,eco-friendly atomization media(biolubricants),and empowering mechanisms of electrostatic atomization MQL are presented.Second,the advanced lubrication and heat transfer mechanisms of biolubricants are revealed by quantitatively comparing MQL with MCF-based wet machining.Third,the distinctive wetting and infiltration mechanisms of electrostatic atomization MQL,combined with its unique empowering mechanism and atomization method,are compared with those of pneumatic atomization MQL.Previous experiments have shown that electrostatic atomization MQL can reduce tool wear by 42.4%in metal cutting and improve the machined surface Ra by 47%compared with pneumatic atomization MQL.Finally,future development directions,including the improvement of the coordination parameters and equipment integration aspects,are proposed. | Wenhao Xu Changhe Li Yanbin Zhang Hafiz Muhammad Ali Shubham Sharma Runze Li Min Yang Teng Gao Mingzheng Liu Xiaoming Wang Zafar Said Xin Liu Zongming Zhou | 2022 | International Journal of Extreme Manufacturing2022，4，4： | 4 |
| 19 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 20 | Stress Effect of Cadmium Absorption between Aloe and Solanum nigrum L显示文摘The stress effect of cadmium absorption between aloe and Solanum nigrum L was studied through a simulation experiment with different cadmium contents in soil.The results showed that the growth characteristics,biomass and Cd content in the plants of aloe and S.nigrum L were closely related to Cd content in the soil,and S.nigrum L and aloe had a strong tolerance to Cd in the experiment.pH of rhizosphere soil with S.nigrum L and aloe planted was generally higher than that of non-rhizosphere soil,which is related to the planting pattern.Compared with aloe,S.nigrum L had a stronger capacity to accumulate Cd,and intercropping S.nigrum L and aloe could inhibit aloe's absorption of Cd,which is favorable to the safe planting of aloe.In addition,S.nigrum L has the potential to restore polluted soil. | Chen Yingzhi Fu Shanming Wang Jianhuang Pei Jie Li Wenhao He Caizhen | 2015 | Meteorological and Environmental Research2015，6，3： | 4 |
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