3篇
您的检索式：作者名="Daisuke Urano"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | G protein controls stress readiness by modulating transcriptional and metabolic homeostasis in Arabidopsis thaliana and Marchantia polymorpha显示文摘The core G protein signaling module,which consists of Gαand extra-large Gα(XLG)subunits coupled with the Gβγdimer,is a master regulator of various stress responses.In this study,we compared the basal and salt stress-induced transcriptomic,metabolomic and phenotypic profiles in Gα,Gβ,and XLG-null mutants of two plant species,Arabidopsis thaliana and Marchantia polymorpha,and showed that G protein mediates the shift of transcriptional and metabolic homeostasis to stress readiness status.We demonstrated that such stress readiness serves as an intrinsic protection mechanism against further stressors through enhancing the phenylpropanoid pathway and abscisic acid responses.Furthermore,WRKY transcription factors were identified as key intermediates of G protein-mediated homeostatic shifts.Statistical and mathematical model comparisons between A.thaliana and M.polymorpha revealed evolutionary conservation of transcriptional and metabolic networks over land plant evolution,whereas divergence has occurred in the function of plant-specific atypical XLG subunit.Taken together,our results indicate that the shifts in transcriptional and metabolic homeostasis at least partially act as the mechanisms of G protein-coupled stress responses that are conserved between two distantly related plants. | Ting-Ying Wu Shalini Krishnamoorthi Kulaporn Boonyaves Isam Al-Darabsah Richalynn Leong Alan M.Jones Kimitsune Ishizaki Kang-Ling Liao Daisuke Urano | 2022 | Molecular Plant2022，15，12： | 0 |
| 2 | Review of novel therapeutic medicines targeting androgen signaling in castration-resistant prostate cancer显示文摘Prostate cancer is the most common male malignant neoplasm.Androgens and the androgen receptor(AR)play a key role in the onset and progression of prostate cancer.The expression of the AR is still preserved in the majority of patients with castration-resistant prostate cancer(CRPC).CRPC is considered to be induced by the following mechanisms:(1)sustained AR activation by enhancing intracellular conversion of adrenal androgens to dehydrotestosterone via a de novo route;(2)AR hypersensitivity;(3)promiscuous activation of AR signaling;and(4)outlaw pathways.Recent advances in the treatment of CRPC include novel medicinestargeting AR signaling pathways.In addition,functional molecular studies have shown that some of the ARregulated genes and AR coregulators are prognostic markers and potential therapeutic targets for prostate cancer,particularly in the castration-resistant state.Therefore,identification of the AR signaling pathways responsible for establishment of CRPC is critical for developing new strategies for the treatment of CRPC. | Daisuke Obinata Kyoko Fujiwara Kenya Yamaguchi Ken-ichi Takayama Tomohiko Urano Hiroki Nagase Satoshi Inoue Satoru Takahashi Noboru Fukuda | 2014 | World Journal of Clinical Urology2014，3，3： | 0 |
| 3 | Heterotrimeric G proteins in crop improvement显示文摘Saline-alkaline soils are found worldwide, affecting over 1 billion hectares of arable lands especially in arid and semiarid regions. Alkaline soils are characterized by the high pH and low nutrient availability as well as high concentrations of bicarbonate and carbonate, being highly detrimental to crop production. According to the UN Food and Agriculture Organization ( FAO and ITPS, 2015 ), approximately 60% of saline soils are concurrently affected by alkalization, posing a serious threat to food security. In recent decades, the breeding objectives for staple crops were mainly focused on yield, quality, and resistance to diseases, leaving alkaline tolerance largely overlooked. Now more than ever, we need to understand the mechanisms of plant alkaline tolerance to develop new crop varieties better adapted to alkaline soil conditions. | Yating Dong Ting-Ying Wu Daisuke Urano | 2023 | Molecular Plant2023，16，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员