| 2 | Biosynthesis,bioactivity,biotoxicity and applications of antimicrobial peptides for human health显示文摘Antimicrobial peptides(AMPs)are the natural antibiotics recognized for their broad-spectrum resistance to bacteria,fungi,viruses and parasites,and influencing the host immune responses.AMPs attributed to good biological effects have been used in various areas of human health,which are trying to completely replace antibiotics,owing to serious drug-resistance bacteria.However,limited bioactivity and potential biotoxicity of some AMPs was neglected,attributable to their hydrophobic structure with positive charges and nonspecific destruction of cell membranes.Various strategies have been used to design and biosynthetic optimized AMPs to improve their bioactivity,productivity,while lowering host toxicity and cost.Here,we focus on the progress made in understanding the AMPs,including biosynthesis(AMP-BioDesign 1.0 and 2.0),bioactivity(e.g.immune regulation and broad-spectrum or nonspecific actions against bacteria,viruses or parasites),and principle biotoxicity(e.g.hemolysis,acute toxicity and instability,ect).The application prospects of AMP for human health,clinical medicine(for novel drugs),tissue engineering and drug delivery system,respectively,are summarized in this review.Furthermore,future prospects and new strategy for the development of effective and low-toxic AMP formulations for human health are discussed. | Daixu Wei Xuwei Zhang | 2022 | Biosafety and Health2022，4，2： | 1 |
| 3 | Preparation of Polymer-Functionalized Iron Oxide Nanoparti-cles and Their Biomedical Properties显示文摘有狭窄的尺寸分布的 Superparamagnetic 氧化铁 nanoparticles 被一个灵巧的一个壶成功地在大规模准备合成方法面对吸水的聚合物,例如聚乙烯乙二醇二酸(HOOC-PEG-COOH ) 并且 poly (丙烯酸的酸)( 泛美航空公司) 。同样准备的产品被粉末 X 光检查衍射(XRD ) 详细调查, thermogravimetric 分析(TGA ) ,传播电子显微镜学(TEM ) ,高分辨率的传播电子显微镜学(HRTEM ) ,散布,并且颤动的动态光(DLS ) 样品磁强计(VSM ) 。在聚合物和氧化铁 nanoparticles 之间的相互作用用 Fourier 被调查转变红外线的 spectrometry (英尺红外) 。结果证明聚合物能被分别地衔接协作和 monodentate 时尚依附到氧化铁 nanoparticle 的表面上。相互作用显著地影响氧化铁 nanoparticle 性质,例如 XRD 衍射紧张,水动力学直径,等电位的点,和浸透磁化。而且,结果在显示的 vitro 实验,那铁 oxide-PEG-COOH nanoparticle 比氧化铁更细胞毒素 -- 泛美航空公司 nanoparticle 由于不同协调模式。 | Qing Lu Daixu Wei Juan Zhou Jianrong Xu Jiejun Cheng Jun Zhu | 2013 | Chinese Journal of Chemistry2013，31，3： | 0 |
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