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| 1 | Morphological observation and rbcL gene sequences studies of two new species,Grateloupia dalianensis H.W.Wang et D.Zhao,sp.nov.and G.yinggehaiensis H.W.Wang et R.X.Luan,sp.nov.(Halymeniaceae,Rhodophyta) from China显示文摘A few species in the genus Grateloupia (Halymeniaceae,Rhodophyta) have been investigated in detail with respect to morphological observations and molecular analyses.In this study,the authors document the vegetative and reproductive structures of two new species of Grateloupia,G.dalianensis H.W.Wang et D.Zhao,sp.nov.and G.yinggehaiensis H.W.Wang et R.X.Luan,sp.nov.They both have the morphological character that carpogonial ampullae and auxiliary cell ampullae are the simple Grateloupia-type.The two species can be distinguished from other species of the genus by their distinctive morphological features respectively.Based on ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) gene sequences,the phylogenetic tree obtained in the study indicated that they are both embedded within the Grateloupia clade.G.dalianensis clusters a subclade with G.asiatica,and G.yinggehaiensis forms a single monophyletic subclade with G.hawaiiana. | ZHAO Dan WANG Hongwei SHENG Yingwen LV Jianzhou LUAN Rixiao | 2012 | Acta Oceanologica Sinica2012，31，2： | 20 |
| 2 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 3 | Effects of Temperature and Moisture on Soil Organic Matter Decomposition Along Elevation Gradients on the Changbai Mountains, Northeast China显示文摘Decomposition of soil organic matter(SOM) is of importance for CO_2 exchange between soil and atmosphere and soil temperature and moisture are considered as two important factors controlling SOM decomposition. In this study, soil samples were collected at 5 elevations ranging from 753 to 2 357 m on the Changbai Mountains in Northeast China, and incubated under different temperatures(5, 10, 15, 20, 25, and 30?C) and soil moisture levels(30%, 60%, and 90% of saturated soil moisture) to investigate the effects of both on SOM decomposition and its temperature sensitivity at different elevations. The results showed that incubation temperature(F = 1 425.10, P < 0.001), soil moisture(F = 1 327.65, P < 0.001), and elevation(F = 1 937.54, P < 0.001) all had significant influences on the decomposition rate of SOM. The significant effect of the interaction of incubation temperature and soil moisture on the SOM decomposition rate was observed at all the 5 sampling elevations(P < 0.001). A two-factor model that used temperature and moisture as variables fitted the SOM decomposition rate well(P < 0.001) and could explain 80%–93% of the variation of SOM decomposition rate at the 5 elevations. Temperature sensitivity of SOM decomposition, expressed as the change of SOM decomposition rate in response to a 10?C increase in temperature(Q_(10)), was significantly different among the different elevations(P < 0.01), but no apparent trend with elevation was discernible. In addition, soil moisture and incubation temperature both had great impacts on the Q_(10) value(P < 0.01), which increased significantly with increasing soil moisture or incubation temperature. Furthermore, the SOM decomposition rate was significantly related to soil total Gram-positive bacteria(R^2= 0.33, P < 0.01) and total Gram-negative bacteria(R^2= 0.58, P < 0.001). These findings highlight the importance of soil moisture to SOM decomposition and its Q_(10) value,which needs to be emphasized under warming climate scenarios. | WANG Dan HE Nianpeng WANG Qing LV Yuliang WANG Qiufeng XU Zhiwei ZHU Jianxing | 2016 | Pedosphere2016，26，3： | 12 |
| 4 | Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways显示文摘Metastasis causes the main lethality in esophageal cancer patient.Garcinol,a natural compound extracted from Gambogic genera,is a histone acetyltransferase(HAT)inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction.In this study,we investigated the effects of garcinol on the metastasis of esophageal cancer in vitro and in vivo.We found that garcinol(5-15μM)dose-dependently inhibited the migration and invasion of human esophageal cancer cell lines KYSE150 and KYSE450 in wound healing,transwell migration,and Matrigel invasion assays.Furthermore,garcinol treatment dose-dependently decreased the protein levels of p300/CBP(transcriptional cofactors and HATs)and p-Smad2/3 expression in the nucleus,thus impeding tumor cell proliferation and metastasis.Knockdown of p300 could inhibit cell metastasis,but CBP knockdown did not affect the cell mobility.It has been reported that TGF-β1 stimulated the phosphorylation of Smad2/3,which directly interact with p300/CBP in the nucleus,and upregulating HAT activity of p300.We showed that garcinol treatment dose-dependently suppressed TGF-β1-activated Smad and non-Smad pathway,inhibiting esophageal cancer cell metastasis.In a tail vein injection pulmonary metastasis mouse model,intraperitoneal administration of garcinol(20 mg/kg)or 5-FU(20 mg/kg)significantly decreased the number of lung tumor nodules and the expression levels of Ki-67,p300,and p-Smad2/3 in lung tissues.In conclusion,our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo,which might be related to the suppression of p300 and TGF-β1 signaling pathways,suggesting the therapeutic potential of Garcinol for metastatic tumors. | Jing Wang Man Wu Dan Zheng Hong Zhang Yue Lv Li Zhang Hong-sheng Tan Hua Zhou Yuan-zhi Lao Hong-xi Xu | 2020 | Acta Pharmacologica Sinica2020，41，1： | 12 |
| 5 | Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats显示文摘 | Li-hong DING Dan LIU Min XU Hong LIU Min WU Ri-ning TANG Lin-li LV Kun-ling MA Bi-cheng LIU | 2014 | Acta Pharmacologica Sinica2014，35，10： | 11 |
| 6 | Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnT^R141W transgenic mice显示文摘 | Hai-ping ZHAO Dan LV Wei ZHANG Li ZHANG Shu-mei WANG Chun-mei MA Chuan QIN Lian-feng ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，3： | 10 |
| 7 | Th17 Cells in autoimmune diseases显示文摘Th17 房间是 CD4 的一个新子集 < 啜 class= “ a-plus-plus ” > 涉及细胞外的病原体和真菌的清理的 + T 房间。积累的证据建议 Th17 房间和他们的签名 cytokines 在多重自体免疫调停的致病有一个枢轴的角色煽动性的疾病。这里,我们在自体免疫的疾病的开发和致病在 Th17 功能上总结最近的研究进步。我们也建议鉴别操作 Th17 的新小分子混合物工作让潜在的治疗学的申请治疗人的自体免疫的疾病,包括风湿性关节炎,全身的豺狼座 erythematosus, Sj ? grens 症候群,煽动性的肠疾病,和多重硬化。 | Lei Han Jing Yang Xiuwen Wang Dan Li Ling Lv Bin Li | 2015 | Frontiers of Medicine2015，9，1： | 9 |
| 8 | Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy显示文摘病理学的心脏的肥大是心失败的不可避免的 forerunner。不管心脏的肥大的病原学, cardiomyocyte mitochondrial 改变总是在这上下文被观察。mitochondrial 先锋蛋白质的进口调节在 pathophysiological 下面维持 mitochondrial 功能的外部膜(汤姆) 建筑群管理的 mitochondrial 的 translocases;然而,它在病理学的心脏的肥大的发展的角色仍然保持不清楚。这里,我们证明 Tom70 是在从人和试验性的动物的病理学的 hypertrophic 心的 downregulated。在 Tom70 表示的减小在 vivo 并且在 vitro 生产了不同病理学的 cardiomyocyte 肥大。指向 Tom70 的眼的 atrophy-1 的有缺点的 mitochondrial 进口触发了细胞内部的氧化应力,它导致了病理学的细胞的回答。重要地,如果有到多样的 pro-hypertrophic 的完整的抵抗的 cardiomyocytes 侮辱,增加了 Tom70 层次。一起,这些结果表明 Tom70 充当安排 hypertrophic 压力和 mitochondrial 回答决定病理学的心脏的肥大的一个分子的开关。 | Jun Li Man Qi Changming Li Dan Shi Dasheng Zhang Duanyang Xie Tianyou Yuan Jing Feng Yi Liu Dandan Liang Xinran Xu Jinjin Chen Liang Xu Hong Zhang Jiangchuan Ye Fei LV Jian Huang Luying Peng Yi-Han Chen | 2014 | Cell Research2014，24，8： | 9 |
| 9 | Inhibitory effect of Salicornia europaea on the marine alga Skeletonema costatum显示文摘Exploiting the negative biochemical interference between plants and algal species has been suggested as a method to control harmful algal blooms.In this work,we investigated the inhibitory effect of the salt marsh halophyte Salicornia europaea against the marine alga Skeletonema costatum.S.europaea suppressed the growth of S.costatum in a nutrient-sufficient co-culture system,indicating that the inhibition of algal growth was because of the phytotoxic effect of S.europaea,rather than nutrient competition.We tested aqueous and organic extracts from S.europaea roots against S.costatum.The organic extracts inhibited growth and affected the cell size and chlorophyll a content of S.costatum in a dose-dependent manner.Among the three tested organic extracts,the methanol extract had the greatest effects on S.costatum,followed by butanol extract,and then the chloroform extract.Two flavonoids,rutin and quercetin-3-D-glucoside,were identified in the methanol extract by high performance liquid chromatography.The concentration of rutin was much higher than that of quercetin-3-D-glucoside.In an algal bioassay,rutin inhibited the growth of S.costatum and the inhibitory effect increased with increasing rutin concentration and with decreasing initial algal density.Therefore,we concluded that S.europaea negatively affects the growth of S.costatum,and that rutin,a metabolite of S.europaea,may play a role in this inhibitory effect. | JIANG Dan HUANG LingFeng LIN YongQing NIE LingLing LV SuLian KUANG TingYun LI YinXin | 2012 | Science China(Life Sciences)2012，55，6： | 8 |
| 10 | Variation of net primary productivity and its drivers in China’s forests during 2000-2018显示文摘Background:Net primary productivity(NPP)in forests plays an important role in the global carbon cycle.However,it is not well known about the increase rate of China’s forest NPP,and there are different opinions about the key factors controlling the variability of forest NPP.Methods:This paper established a statistics-based multiple regression model to estimate forest NPP,using the observed NPP,meteorological and remote sensing data in five major forest ecosystems.The fluctuation values of NPP and environment variables were extracted to identify the key variables influencing the variation of forest NPP by correlation analysis.Results:The long-term trends and annual fluctuations of forest NPP between 2000 and 2018 were examined.The results showed a significant increase in forest NPP for all five forest ecosystems,with an average rise of 5.2 gC·m-2·year-1 over China.Over 90%of the forest area had an increasing NPP range of 0-161 gC·m-2·year-1.Forest NPP had an interannual fluctuation of 50-269 gC.m-2·year-1 for the five major forest ecosystems.The evergreen broadleaf forest had the largest fluctuation.The variability in forest NPP was caused mainly by variations in precipitation,then by temperature fluctuations.Conclusions:All five forest ecosystems in China exhibited a significant increasing NPP along with annual fluctuations evidently during 2000-2018.The variations in China’s forest NPP were controlled mainly by changes in precipitation. | Yuhe Ji Guangsheng Zhou Tianxiang Luo Yakir Dan Li Zhou Xiaomin Lv | 2020 | Forest Ecosystems2020，7，2： | 8 |
| 11 | Expression level of beta-catenin is associated with prognosis of esophageal carcinoma显示文摘AIM: To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC). METHODS: Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real- time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients. RESULTS: Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 ± 0.0369 vs 0.3413 ± 0.1803, P < 0.001) and deeper tumor invasion (0.0751 ± 0.0356 vs 0.3667 ± 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression. CONCLUSION: Beta-catenin expression in ESCC is of great importance. | Lv Ji Xiu-Feng Cao He-Ming Wang Yi-Sheng Li Bin Zhu Jian Xiao Dan Wang | 2007 | World Journal of Gastroenterology2007，13，18： | 8 |
| 12 | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphkl pathway显示文摘目的: FTY720,有低 cytotoxicity 的新 immunomodulatory 药,当前习惯于对待多重硬化。在这研究,我们在白朊在煽动性的房间渗入上调查了 FTY720 的效果老鼠的导致超载的 nephropathy。 | Min XU Dan LIU Li-hong DING Kun-ling MA Min WU Lin-li LV Yi WEN Hong LIU Ri-ning TANG Bi-cheng LIU | 2014 | Acta Pharmacologica Sinica2014，35，12： | 7 |
| 13 | Wave-current bottom shear stresses and sediment re-suspension in the mouth bar of the Modaomen Estuary during the dry season显示文摘On the basis of the measurement data pertaining to waves, current, and sediment in February 2012 in the mouth bar of the Modaomen Estuary, the Soulsby formulae with an iterative method are applied to calculating bottom shear stresses(BSS) and their effect on a sediment re-suspension. Swell- induced BSS have been found to be the most important part of the BSS. In this study, the correlation coefficient between a wavecurrent shear stress and SSC is 0.86, and that between current shear stresses and SSC is only 0.40. The peaks of the SSC are consistent with the height and the BSS of the swell. The swell is the main mechanism for the sediment re-suspension, and the tidal current effect on sediment re-suspension is small. The peaks of the SSC are centered on the high tidal level, and the flood tide enhances the wave shear stresses and the SSC near the bottom. The critical shear stress for sediment re-suspension at the observation station is between 0.20 and 0.30 N/m2. Tidal currents are too weak to stir up the bottom sediment into the flow, but a WCI(wave-current interaction) is strong enough to re-suspend the coarse sediment. | JIA Liangwen REN Jie NIE Dan CHEN Benzhong LV Xiaoying | 2014 | Acta Oceanologica Sinica2014，33，7： | 5 |
| 14 | Advances in metal phosphides for sodium-ion batteries显示文摘Sodium-ion batteries(SIBs)have been extensively studied as the potential alter-native to lithium-ion batteries(LIBs)due to the abundant natural reserves and low price of sodium resources.Nevertheless,Na+ions possess a larger radius than Li+,resulting in slow diffusion dynamics in electrode materials,and thus seeking appropriate anode materials to meet high performance standards has become a trend in the field of SIBs.In this context,owing to the advantages of high theoretical capacity and proper redox potential,metal phosphides(MPs)are considered to be the promising materials to make up for the gap of SIBs anode materials.In this review,the recent development of MPs anode materials for SIBs is reviewed and analyzed comprehensively and deeply,including the synthesis method,advanced modification strategy,electrochemical performance,and Na storage mechanism.In addition,to promote the wide application of the emerg-ing MPs anodes for SIBs,several research emphases in the future are pointed out to overcome challenges toward the commercial application. | Qifei Li Dan Yang Haoliang Chen Xiang Lv Yu Jiang Yuezhan Feng Xianhong Rui Yan Yu | 2021 | SusMat2021，1，3： | 5 |
| 15 | Abnormal Brain Structure and Function in First-Episode Childhood- and Adolescence-Onset Schizophrenia: Association with Clinical Symptoms显示文摘Dear Editor,Schizophrenia is one of the most complicated and serious psychiatric disorders, and patients often show markedly disrupted structural and functional abnormalities during resting-state imaging scans of the brain. Patients with firstepisode childhood- and adolescence-onset schizophrenia (CAOS) refers to individuals under the age of 18 years whose first episode of illness had occurred before they were 13 years old [1]. The symptoms are similar to adultonset schizophrenia-auditory hallucinations or language deficits and abnormal cognition. However, CAOS patients often present with more severe psychotic symptoms and have a worse prognosis and treatment effect [2]. | Yanhong Xia Dan Lv Yinghui Liang Haisan Zhang Keyang Pei Rongrong Shao Yali Li Yan Zhang Yuling Li Jinghua Guo Luxian Lv Suqin Guo | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 16 | Influences of Ca and Y Addition on the Microstructure and Corrosion Resistance of Vacuum Die-Cast AZ91 Alloy显示文摘The influences of Ca and Y additions on the microstructure and corrosion resistance of vacuum die-cast AZ91 alloys were investigated by optical microscope,electron scanning microscope,weight-loss test,and electrochemical corrosion experiment.The results indicate that the Ca or Ca and Y additions refined the microstructure and decreased the amount of Mg17Al12 phase on grain boundaries in the alloys.Meanwhile,the addition of Ca and Y led to the formation of network Al2 Ca phase and rod-like Al2 Y phase,improved the corrosion resistance of AZ91 magnesium alloy.Compared with AZ91 alloy,the corrosion rate of AZ91–1.5Ca–1.0Y alloy was decreased to 16.2%,and its corrosion current density was dropped by one order of magnitude after immersion in 3.5 wt% NaCl solution for 24 h. | Feng Wang Jibao Li Jing Liu Dan Lv Pingli Mao Zheng Liu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 4 |
| 17 | Small-scale spatial analysis of intermediate and definitive hosts of Angiostrongylus cantonensis显示文摘Background:Angiostrongyliasis is a food-borne parasitic zoonosis.Human infection is caused by infection with the third-stage larvae of Angiostrongylus cantonensis.The life cycle of A.cantonensis involves rodents as definitive hosts and molluscs as intermediate hosts.This study aims to investigate on the infection status and characteristics of spatial distribution of these hosts,which are key components in the strategy for the prevention and control of angiostrongyliasis.Methods:Three villages from Nanao Island,Guangdong Province,China,were chosen as study area by stratified random sampling.The density and natural infection of Pomacea canaliculata and various rat species were surveyed every three months from December 2015 to September 2016,with spatial correlations of the positive P.canaliculata and the infection rates analysed by ArcGIS,scan statistics,ordinary least squares(OLS)and geographically weighted regression(GWR)models.Results:A total of 2192 P.canaliculata specimens were collected from the field,of which 1190 were randomly chosen to be examined for third-stage larvae of A.cantonensis.Seventy-two Angiostrongylus-infected snails were found,which represents a larval infection rate of 6.1%(72/1190).In total,110 rats including 85 Rattus norvegicus,10 R.flavipectus,one R.losea and 14 Suncus murinus were captured,and 32 individuals were positive(for adult worms),representing an infection rate of 29.1%of the definitive hosts(32/110).Worms were only found in R.norvegicus and R.flavipectus,representing a prevalence of 36.5%(31/85)and 10%(1/10),respectively in these species,but none in R.losea and S.murinus,despite testing as many as 32 of the latter species.Statistically,spatial correlation and spatial clusters in the spatial distribution of positive P.canaliculata and positive rats existed.Most of the spatial variability of the host infection rates came from spatial autocorrelation.Nine spatial clusters with respect to positive P.canaliculata were identified,but only two correlated to infection rates.The results show that corrected Akaike information criterion,R2,R2 adjusted andσ2 in the GWR model were superior to those in the OLS model.Conclusions:P.canaliculata and rats were widely distributed in Nanao Island and positive infection has also been found in the hosts,demonstrating that there was a risk of angiostrongyliasis in this region of China.The distribution of positive P.canaliculata and rats exhibited spatial correlation,and the GWR model had advantage over the OLS model in the spatial analysis of hosts of A.cantonensis. | Qiu-An Hu Yi Zhang Yun-Hai Guo Shan Lv Shang Xia He-Xiang Liu Yuan Fang Qin Liu Dan Zhu Qi-Ming Zhang Chun-Li Yang Guang-Yi Lin | 2018 | Infectious Diseases of Poverty2018，7，1： | 4 |
| 18 | miR395-regulated sulfate metabolism exploits pathogen sensitivity to sulfate to boost immunity in rice显示文摘MicroRNAs (miRNAs) play important roles in plant physiological activities. However, their roles and molecular mechanisms in boosting plant immunity, especially through the modulation of macronutrient metabolism in response to pathogens, are largely unknown. Here, we report that an evolutionarily conserved miRNA, miR395, promotes resistance to Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc), two destructive bacterial pathogens, by regulating sulfate accumulation and distribution in rice. Specifically, miR395 targets and suppresses the expression of the ATP sulfurylase gene OsAPS1, which functions in sulfate assimilation, and two sulfate transporter genes, OsSULTR2;1 and OsSULTR2;2, which function in sulfate translocation, to promote sulfate accumulation, resulting in broad-spectrum resistance to bacterial pathogens in miR395-overexpressing plants. Genetic analysis revealed that miR395-triggered resistance is involved in both pathogen-associated molecular pattern-triggered immunity and R gene-mediated resistance. Moreover, we found that accumulated sulfate but not S-metabolites inhibits proliferation of pathogenic bacteria, revealing a sulfate-mediated antibacterial defense mechanism that differs from sulfur-induced resistance. Furthermore, compared with other bacteria, Xoo and Xoc, which lack the sulfate transporter CysZ, are sensitive to high levels of extracellular sulfate. Accordingly, miR395-regulated sulfate accumulation impaired the virulence of Xoo and Xoc by decreasing extracellular polysaccharide production and biofilm formation. Taken together, these results suggest that rice miR395 modulates sulfate metabolism to exploit pathogen sensitivity to sulfate and thereby promotes broad-spectrum resistance. | Zeyu Yang Shugang Hui Yan Lv Miaojing Zhang Dan Chen Jingjing Tian Haitao Zhang Hongbo Liu Jianbo Cao Wenya Xie Changyin Wu Shiping Wang Meng Yuan | 2022 | Molecular Plant2022，15，4： | 3 |
| 19 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 20 | Event-triggered neural network control of autonomous surface vehicles over wireless network显示文摘In this paper, an event-triggered neural network control method is proposed for autonomous surface vehicles subject to uncertainties and input constraints over wireless network. An event-triggered mechanism with three logic rules is employed to determine the wireless data transmission of states and control inputs. An event-driven neural network is applied to approximate the uncertainties using aperiodic sampled states. In addition, a predictor is employed to update the weights of neural network. An event-based bounded kinetic control law is applied to address the actuator constraints. The advantage of the proposed event-triggered neural network control approach is that the network traffic can be reduced while guaranteeing system stability and speed following performance. The closed-loop control system is proved to be input-tostate stable via cascade theory. The Zeno behavior can be avoided via the proposed event-triggered neural network control approach. A simulation example is provided to demonstrate the effectiveness of the proposed event-triggered neural network control approach for autonomous surface vehicles. | Mingao LV Dan WANG Zhouhua PENG Lu LIU Haoliang WANG | 2020 | Science China(Information Sciences)2020，63，5： | 3 |
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