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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 3 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11, 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 4 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J H | 2012 | Prenatal Diagnosis2012，32，13： | 1 |
| 5 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 6 | Clinical application of massively parallel sequencing-based prenatal non invasive fetal trisomy test for trisomies 21 and ]8 in 11 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J etal | 2012 | Prenat Diagn2012，32，13： | 1 |
| 7 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，： | 1 |
| 8 | Preparation and characterization of colla- gen - chitosan - chondroitin sulfate com- posite membranes 显示文摘 | Wang K J Dan N H Xiao S W | 2012 | The Journal of Membrane Biology2012，245，11： | 1 |
| 9 | The ring-opening polymerization of D,L-lactide in the melt initiated with tetra- phenyltin 显示文摘 | KOHN F E WAN DEN BERG J W A DAN DE RIDDER G | 1984 | Journal of Applied Polymer Science1984，29，12： | 1 |
| 10 | A model for strain-induced martensitic transformation of TRIP steel with strain rate显示文摘 | Dan W J Zhang W G Li S H | 2007 | Comput Mater Sci2007，40，1： | 1 |
| 11 | Ligand-controlled mixed-valence copper rectangular grid-type coordination polymers based on pyridyl-terpyridine显示文摘 | HOU L DAN L SHI W J | 2005 | Inorg Chem2005，44，： | 1 |
| 12 | Exotic plant species invade hot spots of native plant diversity显示文摘 | THOMAS J STOHLGREN DAN BINKLEY GENEVA W CHONG | 1999 | Ecological Monographs1999，69，1： | 1 |
| 13 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 14 | Clinical application of mas- sively parallel sequencing-based prenatal noninvasive fe- tal trisomy test for trisomies 21 and 18 in 11,105 preg- nancies with mixed risk factors 显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 15 | Clinical application of massivelyparallel sequencing-based prenatal noninvasive fetal trisomy test fortrisomies 21 and 18 in 11105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | PrenatDiagn2012，，32： | 1 |
| 16 | The effect of strain-induced martensitic transformation on mechanical properties of TRIP steel显示文摘 | DAN W J LI S H ZHANG W G | 2008 | Materials Design2008，29，3： | 1 |
| 17 | The effect of strain-induced martensitic transformation on mechanical properties of TRIP steel显示文摘 | DAN W J LI S H ZHANG W G | 2008 | Materials & Design2008，29，3： | 1 |
| 18 | The incidence of nosocomail infection in the intensive care uint显示文摘 | Rozaidi S W Sukro J Dan A | 2001 | Med J Malaysia2001，56，2： | 1 |
| 19 | The effect of strain-in- duced martensitic transformation on mechanical properties of TRIP steel 显示文摘 | Dan W J Li S H Zhang W G | 2008 | Materials and Design2008，29，： | 1 |
| 20 | Finite element simulation on strain-induced martensitic transformation effects in TRIP steel sheet forming显示文摘 | Dan W J Zhang W G Li S H | | 0，，03： | 1 |
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