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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 3 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Voltage regulation in LV grids by coordinated volt-var control strategies显示文摘The increasing penetration level of photovoltaic(PV)power generation in low voltage(LV)networks results in voltage rise issues,particularly at the end of the feeders.In order to mitigate this problem,several strategies,such as grid reinforcement,transformer tap change,demand-side management,active power curtailment,and reactive power optimization methods,show their contribution to voltage support,yet still limited.This paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level in a representative LV network in Bornholm Island using a multi-objective genetic algorithm.The approach is to increase the reactive power contribution of the inverters closest to the transformer during overvoltage conditions.Two standard reactive power control concepts,cosu(P)and Q(U),are simulated and compared in terms of network power losses and voltage level along the feeder.As a practical implementation,a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power level.The proposed testing platform has been developed within PVNET.dk project,which targets to study the approaches for large PV power integration into the network,without the need of reinforcement. | Miguel JUAMPEREZ Guangya YANG Søren Bækhøj KJÆR | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，4： | 10 |
| 6 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 7 | Voltage rise mitigation for solar PV integration at LV grids Studies from PVNET.dk显示文摘Solar energy from photovoltaic(PV)is among the fastest developing renewable energy systems worldwide.Driven by governmental subsidies and technological development,Europe has seen a fast expansion of solar PV in the last few years.Among the installed PV plants,most of them are situated at the distribution systems and bring various operational challenges such as power quality and power flow management.The paper discusses the modelling requirements for PV system integration studies,as well as the possible techniques for voltage rise mitigation at low voltage(LV)grids for increasing PV penetration.Potential solutions are listed and preliminary results are presented. | Guangya YANG Francesco MARRA Miguel JUAMPEREZ Søren Bækhøj KJÆR Seyedmostafa HASHEMI JacobØSTERGAARD Hans Henrik IPSEN Kenn H.B.FREDERIKSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 5 |
| 8 | 食管扩张——一种胃食管反流触发机制显示文摘目的 :明确食管扩张时下食管括约肌发生松弛状态下胃食管反流的发生率。方法 :12例健康志愿者在餐前和餐后同时检测食管压力和 pH ,食管扩张是通过快速和缓慢的气体注射诱发。 结果 :引起完全的下食管扩约肌松弛的气体阈值量平均为 (11 0± 1 0 )ml。只有极少的松弛伴有继发蠕动。快速注气下食管括约肌的松弛时间为(13.0± 1.5 )s;慢速注射时食管括约肌的松弛时间是 (16 0± 2 0 )s。由快速阈值量气体注射引起LES松弛并伴有胃食管反流率 ,在餐后为 (2 2± 6 ) % ;缓慢注射时为 (2 3± 10 ) %。对于快速食管扩张 ,单独的下食管括约肌松弛伴随反流的百分比显著高于伴有继发蠕动的下食管括约肌松弛时出现的胃食管反流情况。结论 :(1)胃食管反流可以发生在由食管扩张引起的下食管括约肌松弛期内 ;(2 )食管扩张可以引起不伴随继发蠕动的单纯下食管括约肌松弛 ;(3)单纯下食管括约肌松弛时的胃食管反流发生率显著高于伴有继发蠕动的情况。 | 谢鹏雁 Eytan Bardan Junlong Ren Walter J Hogan Reza Shaker | 2000 | 北京医科大学学报2000，32，2： | 5 |
| 9 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 10 | Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract显示文摘Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients. | Floor WT Vergouwe Madeleine Gottrand Bas PL Wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon CW Spaander | 2018 | World Journal of Gastroenterology2018，24，9： | 3 |
| 11 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 12 | Iron in the NEEM ice core relative to Asian loess records over the last glacial–interglacial cycle显示文摘Mineral dust can indirectly affect the climate by supplying bioavailable iron(Fe)to the ocean.Here,we present the records of dissolved Fe(DFe)and total Fe(TDFe)in North Greenland Eemian Ice Drilling(NEEM)ice core over the past 110 kyr BP.The Fe records are significantly negatively correlated with the carbon-dioxide(CO_(2))concentrations during cold periods.The results suggest that the changes in Fe fluxes over the past 110 kyr BP in the NEEM ice core are consistent with those in Chinese loess records because the mineral-dust distribution is controlled by the East Asian deserts.Furthermore,the variations in the dust input on a global scale are most likely driven by changes in solar radiation during the last glacial–interglacial cycle in response to Earth’s orbital cycles.In the last glacial–interglacial cycle,the DFe/TDFe ratios were higher during the warm periods(following the post-Industrial Revolution and during the Holocene and last interglacial period)than during the main cold period(i.e.the last glacial maximum(LGM)),indicating that the aeolian input of iron and the iron fertilization effect on the oceans have a non-linear relationship during different periods.Although the burning of biomass aerosols has released large amounts of DFe since the Industrial Revolution,no significant responses are observed in the DFe and TDFe variations during this period,indicating that severe anthropogenic contamination has no significant effect on the DFe(TDFe)release in the NEEM ice core. | Cunde Xiao Zhiheng Du Mike J Handley Paul A Mayewski Junji Cao Simon Schüpbach Tong Zhang Jean-Robert Petit Chuanjin Li Yeongcheol Han Yuefang Li Jiawen Ren | 2021 | National Science Review2021，8，7： | 2 |
| 13 | 生理过度觉醒相关失眠增加高血压风险显示文摘先前的研究显示,失眠和客观睡眠时间过短与高血压风险增加相关,并推测其潜在的机制是生理过度觉醒。在该研究中,研究者通过多次睡眠潜伏期试验(multiplesleeplatencytest,MSLT)——一种睡眠/觉醒的标准测试,探讨与生理过度觉醒相关的失眠是否与高血压风险增加相关。 | Li Y Vgontzas AN Fernandez-Mendoza J Bixler EO Sun Y Zhou J Ren R Li T Tang X 戴伦 练桂丽 | 2015 | 中华高血压杂志2015，23，2： | 2 |
| 14 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 15 | Active Crohn’s disease is associated with low vitamin D levels显示文摘 | S?ren Peter J?rgensen Christian Lodberg Hvas J?rgen Agnholt Lisbet Ambrosius Christensen Lene Heickendorff Jens Frederik Dahlerup | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 16 | Synthesis of large arrays of well-aligned carbon nanotube on glass 显示文摘 | Ren Z F Huang Z P Xu J W | 1998 | Science1998，282，： | 2 |
| 17 | Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Xinyu Zhou Jianjun Chen Qi Li Gaoping Ren Guoen Yao Ming Liu Qiang Dong Jìng Guo Leilei Li Jing Guo Peng Xie | 2012 | Stroke2012，，11： | 2 |
| 18 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 19 | Induction of alpha-fetoprotein- specific CD4- and CD8-mediated T-cell response using RNA-trans-fected dendritic cells显示文摘 | Zhang HM Zhang LW Ren J | 2006 | Cell Immunol2006，239，2： | 1 |
| 20 | High-throughput single-strand conformation polymorphism analysis by capillary electrophoresis 显示文摘 | REN J C | 2000 | J Chromatogr: B2000，741，2： | 1 |
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